Results 101 to 110 of about 1,120 (154)

From Genome to Pharmacome: Current Status and Future Perspectives of Multi-Omics Integration in Traditional Chinese Medicine Research. [PDF]

Genes (Basel)
Yu T, Chen C, Hu P, Zou Y, Zhang J, Zhu Q, Yang T.   +6 more
europepmc   +1 more source

Advances in the Structures, Pharmacological Activities, and Biosynthesis of Plant Diterpenoids. [PDF]

J Microbiol Biotechnol
Li L, Fu J, Liu N.
europepmc   +1 more source

The Paclitaxel Biosynthesis Pathway Unlocked. [PDF]

Research (Wash D C)
Martinelli L, Papon N, Courdavault V.
europepmc   +1 more source

Insights into taxadiene synthase catalysis and promiscuity facilitated by mutability landscape and molecular dynamics. [PDF]

Planta
He S, Abdallah II, van Merkerk R, Quax WJ.   +3 more
europepmc   +1 more source

Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase [PDF]

Chemistry and Biology, 2000
The committed step in the biosynthesis of the anticancer drug taxol in yew (Taxus) species is the cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene. The enzyme taxadiene synthase catalyzes this complex olefin cation cyclization cascade involving the formation of three rings and three stereogenic centers.Recombinant taxadiene synthase ...
Rodney Croteau, Robert M Coates, David C Williams   +2 more
exaly   +5 more sources

Metabolic engineering of Nicotiana benthamiana for the increased production of taxadiene

Plant Cell Reports, 2014
We report the production of taxadiene by transformation of N. benthamiana with a taxadiene synthase gene. The production was significantly increased by an elicitor treatment or metabolic pathway shunting. Paclitaxel (Taxol(®)) was first isolated from the bark of the pacific yew tree as an anticancer agent and has been used extensively to treat various ...
Md Mohidul Hasan, Sang Hee Shim, Kwang-Hyun Baek   +2 more
exaly   +4 more sources

QM/MM study of the taxadiene synthase mechanism [PDF]

Journal of Computational Chemistry, 2019
Combined quantum mechanics/molecular mechanics (QM/MM) calculations were used to investigate the reaction mechanism of taxadiene synthase (TXS). TXS catalyzes the cyclization of geranylgeranyl diphosphate (GGPP) to taxadiene (T) and four minor cyclic products. All these products originate from the deprotonation of carbocation intermediates.
Walter Thiel, Andres M Escorcia, Jeaphianne P M van Rijn   +2 more
exaly   +5 more sources

In situ solid-liquid extraction enhances recovery of taxadiene from engineered Saccharomyces cerevisiae cell factories [PDF]

Separation and Purification Technology, 2022
Microbial cell factories express diverse heterologous pathways for the production of a wide range of valuable natural products. However, the recovery and purification of such compounds is a major bottleneck in commercialization. In this study, a novel in
Leonardo Rios Solis, Gary Loake, Laura Walls   +2 more
exaly   +5 more sources

Some of the next articles are maybe not open access.

Related searches:

Importation of taxadiene synthase into chloroplast improves taxadiene production in tobacco

Planta, 2021
Importation of taxadiene synthase into chloroplasts is important for the efficient heterologous production of taxadiene. Taxadiene, the first committed precursor to taxol, is synthesized from geranylgeranyl pyrophosphate (GGPP) by action of taxadiene synthase (TS).
Jiang Zhang, Ling Chang, Shengchun Li
exaly   +3 more sources