Results 21 to 30 of about 162,388 (137)
Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis. [PDF]
Nature, 2011 With more than 55,000 members identified so far in all forms of life, the family of terpene or terpenoid natural products represents the epitome of molecular biodiversity. A well-known and important member of this family is the polycyclic diterpenoid Taxol (paclitaxel), which promotes tubulin polymerization and shows remarkable efficacy in cancer ...
Köksal M +4 more
europepmc +4 more sources
Frontiers in Bioengineering and Biotechnology, 2023 Taxadiene is an important precursor in taxol biosynthesis pathway, but its biosynthesis in eukaryotic cell factories is limited, which seriously hinders the biosynthesis of taxol.
Chenglong Zhang +7 more
doaj +1 more source
Cells, 2022 Despite huge progress in biotechnological approaches to paclitaxel production, Taxus spp. in vitro culture productivity still remains a challenge. This could be solved by developing a new strategy engaging mechanisms of the primed defence response joined
Katarzyna Sykłowska-Baranek +4 more
doaj +1 more source
Frontiers in Plant Science, 2021 Taxol is a rare secondary metabolite that accumulates considerably in Taxus species under salicylic acid (SA) and methyl jasmonate treatment. However, the molecular mechanism of its accumulation remains unclear.
Ying Chen +26 more
doaj +1 more source
Frontiers in Plant Science, 2022 Paclitaxel (Taxol), a highly modified diterpene agent mainly obtained from Taxus species, is the most widely used anticancer drug. Abscisic acid (ABA) is a well-known stress hormone that plays important roles in the secondary metabolism of plants, and it
Xiaoying Cao +4 more
doaj +1 more source
Biotechnology and Bioengineering, Volume 120, Issue 8, Page 2160-2174, August 2023., 2023 The production of T5α‐yl Acetate using engineered S. cerevisiae cells was significantly enhanced through the implementation of a novel in situ product recovery method utilizing three biocompatible and highly absorbent polymeric resins simultaneously. Optimization using Design of Experiments facilitated a semi‐continuous cultivation strategy, yielding a
Jorge H. Santoyo‐Garcia +6 more
wiley +1 more source
Plant terpene specialized metabolism: complex networks or simple linear pathways?
The Plant Journal, Volume 114, Issue 5, Page 1178-1201, June 2023., 2023 SUMMARY From the perspectives of pathway evolution, discovery and engineering of plant specialized metabolism, the nature of the biosynthetic routes represents a critical aspect. Classical models depict biosynthesis typically from an end‐point angle and as linear, for example, connecting central and specialized metabolism. As the number of functionally
Emily R. Lanier +2 more
wiley +1 more source
Biotechnology and Bioengineering, Volume 120, Issue 1, Page 82-94, January 2023., 2023 Abstract Plants produce a large number of secondary metabolites, known as phytometabolites that may be employed as medicines, dyes, poisons, and insecticides in the field of medicine, agriculture, and industrial use, respectively. The rise of genome management approaches has promised a factual revolution in genetic engineering.
Sicon Mitra +10 more
wiley +1 more source
Plant Biotechnology Journal, Volume 21, Issue 1, Page 165-175, January 2023., 2023 Based on the structures of SmMDS and the results of mutagenesis experiment, we find a channel between the two active sites, identify the intermediate pimar‐15‐en‐8‐yl+ and propose the cyclization mechanism of (+)‐CPP to miltiradiene. Summary Selaginella moellendorffii miltiradiene synthase (SmMDS) is a unique bifunctional diterpene synthase (diTPS ...
Yuru Tong +9 more
wiley +1 more source
, 2006 Taxadiene synthase catalyzes the formation of taxadiene from GGPP, the universal building block of diterpenes. The cyclization of GGPP to taxadiene is generally thought to proceed through a series of monocyclic and bicyclic carbocation intermediates, all
Chow, Siew Yin
core +3 more sources