Results 41 to 50 of about 162,388 (137)

Synthesis of Amines for Active Pharmaceutical Ingredients Using the Whole‐Cell Factory Saccharomyces Cerevisae

ChemBioChem, Volume 27, Issue 9, 14 May 2026.
This review highlights advances in engineering Saccharomyces cerevisiae for the sustainable biocatalytic production of pharmaceutically relevant amines, amino alcohols, amino acids, and complex alkaloids. It focuses on strategies to increase productivity, including enhanced enzyme expression, cofactor regeneration, precursor channeling, pathway ...
Natalia Kwiatos, Stephen Ossel, Francesco G. Mutti   +2 more
wiley   +1 more source

Diterpenoid Diversity across Land Plants

Helvetica Chimica Acta, Volume 109, Issue 4, April 2026.
Here we bridge the knowledge of diterpene chemical diversity, biosynthesis, and evolution from nonvascular mosses and liverworts to that known from vascular plants. ABSTRACT The diverse array of diterpenoid natural products stems from the ease of manipulating the promiscuity of diterpene cyclases.
Anita Berg, Chad K. Papenfuhs, Amy E. Fraley   +2 more
wiley   +1 more source

Perfluorodecalin-supported system enhances taxane production in hairy root cultures of Taxus x media var. Hicksii carrying a taxadiene synthase transgene [PDF]

Plant Cell, Tissue and Organ Culture (PCTOC), 2014
Enhanced taxane production was observed in a hybrid, two liquid phases containing, cultures of Taxus x media var. Hicksii hairy root carrying a taxadiene synthase transgene, supported with liquid perfluorodecalin (PFD) in degassed or aerated form. The hairy root cultures were elicited with methyl jasmonate (MJ, 100 μM) or coronatine (COR, 1 μM), and ...
Syklowska Baranek, Katarzyna, Pilarek, Maciej, Bonfill Baldrich, Ma. Mercedes, Kafel, K., Pietrosiuk, A.   +4 more
openaire   +2 more sources

Genome‐scale Metabolic Modeling Guided Escherichia coli Engineering for De Novo Biosynthesis of Chrysanthemic Acid

Advanced Science, Volume 13, Issue 2, 9 January 2026.
Genome‐scale metabolic modeling is preceded to the engineered E. coli cell factory for the de novo biosynthesis of biopesticide chrysanthemic acid. The debranching strategy redirects metabolic flux, enhancing precursor and target compound production.
Jiangpeng Yu, Kelin Cheng, Shenyang Qu, Jie Wang, Xun Wang, Cheng Zhao, Wei Li   +6 more
wiley   +1 more source

Sobralene, a new sex-aggregation pheromone and likely shunt metabolite of the taxadiene synthase cascade, produced by a member of the sand fly Lutzomyia longipalpis specied complex [PDF]

, 2018
A new sex-aggregation pheromone, sobralene, produced by the sand fly Lutzomyia longipalpis from Sorbral (Ceara State, Brazil) is shown to have the novel 6,12-membered ring-fused diterpene structure 3.
Pattenden, Gerald, Palframan, Matthew J., Hamilton, James G. C., Bandi, Krishna K.   +3 more
core   +3 more sources

Studies on Taxadiene Synthase:  Interception of the Cyclization Cascade at the Isocembrene Stage with GGPP Analogues

, 2016
The cyclization of GGPP to taxadiene, catalyzed by taxadiene synthase, has been suggested to proceed through a series of monocyclic isocembrenyl- and bicyclic verticillyl-carbocationic intermediary stages.
Qiulong Huang (274980), Siew Yin Chow (2662336), A. Ian Scott (2533291), Samik Nanda (2662333), Howard J. Williams (1327818)   +4 more
core   +1 more source

An integrative database and its application for plant synthetic biology research

Plant Communications
Plant synthetic biology research requires diverse bioparts that facilitate the redesign and construction of new-to-nature biological devices or systems in plants.
Chenfei Tian, Jianhua Li, Yuhan Wu, Guangyi Wang, Yixin Zhang, Xiaowei Zhang, Yuwei Sun, Yong Wang   +7 more
doaj   +1 more source

Cloning of taxadiene synthase gene into Arabidopsis thaliana (ecotype Columbia-0)

African Journal of Biotechnology, 2010
Paclitaxel (Taxol), a complex diterpenoid, produced by yew tree (Taxus sp.) is the most important chemotherapeutic agent that is widely used against a variety of malignancies such as ovarian and breast cancers. However, destructive methods for its production from natural resources together with currently used low-yielding industrial production systems ...
Khani, S, Sohani, MM, Mahna, N, Barar, J, Hejazi, MS, Nazemieh, H, Atashpaz, S, Dadpour, MR, Omidi, Y   +8 more
openaire   +3 more sources

Paclitaxel production and PAL activity in hairy root cultures of Taxus x media var. Hicksii carrying a taxadiene synthase transgene elicited with nitric oxide and methyl jasmonate [PDF]

Acta Physiologiae Plantarum, 2015
The role of sodium nitroprusside (SNP, 10 μM), a nitric oxide (NO) donor, and/or methyl jasmonate (MJ, 100 μM) spiked with l-phenylalanine (PHEN, 100 μM) and additional sucrose (S; 30 g l−1), in taxane production and phenyl ammonia lyase (PAL) activity in cultures of two Taxus media x var.
Katarzyna Sykłowska-Baranek, Marta Karolina Grech-Baran, Naliwajski, M., Bonfill, M., Agnieszka Irena Pietrosiuk   +4 more
openaire   +1 more source

Synthetic evolution of Saccharomyces cerevisiae for biomanufacturing: Approaches and applications

mLife, Volume 4, Issue 1, Page 1-16, February 2025.
Abstract The yeast Saccharomyces cerevisiae is a well‐studied unicellular eukaryote with a significant role in the biomanufacturing of natural products, biofuels, and bulk and value‐added chemicals, as well as the principal model eukaryotic organism utilized for fundamental research.
Zhen Wang, Xianni Qi, Xinru Ren, Yuping Lin, Fanli Zeng, Qinhong Wang   +5 more
wiley   +1 more source