Improving 10-deacetylbaccatin III-10-β-O-acetyltransferase catalytic fitness for Taxol production
Nature Communications, 2017 Taxol is a widely used anticancer drug that is found in very low amounts in the bark of Taxus plants. Here, the authors improve the catalytic fitness of DBAT, an enzyme that catalyses the conversion of tree by products into taxol, enabling the design of ...
Bing-Juan Li +6 more
doaj +1 more source
Restoration of Taxol Sensitivity of Multidrug-Resistant Cells by the Cyclosporine SDZ PSC 833 and the Cyclopeptolide SDZ 280-446 [PDF]
, 2017 Background: Taxol, a promising agent for the treatment of cancer, has entered phase II clinical trials. Nevertheless, it belongs to the class of compounds that show impaired retention in multidrug-resistant cells expressing P-glycoprotein (Pgp), a drug ...
Jachez, Bénédicte +2 more
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Direct Interaction between Survivin and Smac/DIABLO Is Essential for the Anti-apoptotic Activity of Survivin during Taxol-induced Apoptosis [PDF]
, 2003 Zhiyin Song, Xuebiao Yao, Mian Wu
openalex +1 more source
Model of ionic currents through microtubule nanopores and the lumen
, 2009 It has been suggested that microtubules and other cytoskeletal filaments may act as electrical transmission lines. An electrical circuit model of the microtubule is constructed incorporating features of its cylindrical structure with nanopores in its ...
A. M. Gomez +10 more
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Injectable diblock copolypeptide hydrogel provides platform to maintain high local concentrations of taxol and local tumor control [PDF]
, 2019 Introduction Surgical resection and systemic chemotherapy with temozolomide remain the mainstay for treatment of glioblastoma. However, many patients are not candidates for surgical resection given inaccessible tumor location or poor health status ...
Bernstein, Alexander +9 more
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MAP7 regulates axon morphogenesis by recruiting kinesin-1 to microtubules and modulating organelle transport. [PDF]
, 2018 Neuronal cell morphogenesis depends on proper regulation of microtubule-based transport, but the underlying mechanisms are not well understood.
Ma, Le +3 more
core +1 more source
Exploration of paclitaxel (Taxol) as a treatment for malignant tumors in cats: a descriptive case series [PDF]
, 2014 J. Kim, Mary Doerr, Barbara E. Kitchell
openalex +1 more source
The Cytotoxic Effects of Silymarin on the 4T1 Cell Line Derived from BALB/c Mice Mammary Tumors
Journal of Medicinal Plants, 2014 Background: There is an increasing interest in identifying potent cancer preventive and therapeutic agents. Silymarin is a flavonoids complex extracted from the milk thistle (Silybum marianum L.) seeds.
SMA Shariatzadeh +4 more
doaj
The prognostic role of VEGF in head and neck squamous cell carcinoma [PDF]
, 2017 Emerging from potentially malignant disorders that in most cases will never become cancerous, head and neck squamous cell carcinoma (HNSCC) is a cancer that is extremely difficult to diagnose early.
Mathew, Rohit Thomas
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