Results 61 to 70 of about 64,747 (267)
Cancer Cell International, 2019 Background Breast cancer, the most common invasive cancer of women, is a malignant neoplasm and the second main cause of cancer death. Resistance to paclitaxel (Taxol), one of the frequently used chemotherapy agents for breast cancer, presents a major ...
Lu Hou +7 more
doaj +1 more source
High expression of RIPK2 is associated with Taxol resistance in serous ovarian cancer
Journal of Ovarian Research, 2022 Background Taxol resistance in serous ovarian cancer is responsible for its poor prognosis, yet the underlying mechanism is still poorly understood. Thus, we probed the mechanism of Taxol resistance in serous ovarian cancer with multiple bioinformatic ...
Yuqing Shen +6 more
doaj +1 more source
Response Detection of Castrate-Resistant Prostate Cancer to Clinically Utilised and Novel Treatments by Monitoring Phospholipid Metabolism [PDF]
, 2017 The authors gratefully acknowledge funding from Grampian NHS Endowment. The use of Professor Zanda’s and Jaspar’s NMR equipment and Russell Gray’s assistance are also gratefully acknowledged.Peer reviewedPublisher ...
Alzyoud, Kholoud S +3 more
core +2 more sources
ChemistryOpen, EarlyView.Natural products derived from plants, animals, fungi, bacteria, and minerals contain diverse bioactive classes such as alkaloids, flavonoids, terpenoids, saponins, tannins, and phenolics. These natural products work through different mechanisms, including ROS inhibition, NF‐κB suppression, and cytokine regulation, and exhibit wide applications across ...
Sajid Ali +4 more
wiley +1 more source
Food FrontiersDrug resistance in non‐small cell lung cancer (NSCLC) limits its therapeutic efficacy. Allicin may help to solve the problem of Taxol resistance in NSCLC.
Xudong Gao +4 more
doaj +1 more source
Imaging malaria parasites across scales and time
Journal of Microscopy, EarlyView.Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley +1 more source
The mechanism of anaphase spindle elongation: uncoupling of tubulin incorporation and microtubule sliding during in vitro spindle reactivation. [PDF]
, 1988 To study tubulin polymerization and microtubule sliding during spindle elongation in vitro, we developed a method of uncoupling the two processes. When isolated diatom spindles were incubated with biotinylated tubulin (biot-tb) without ATP, biot-tb was ...
CANDE, W. Zacheus +2 more
core
Plant Biotechnology Journal, EarlyView.ABSTRACT The synthesis and accumulation of active ingredients in medicinal plants are distributed in specific organs, tissues, and cell types, which are important for the exploitation of medicinal plants. However, the fine distribution of active ingredients is difficult to know. Here, the system of mass spectrometry imaging (MSI) integrated with single‐
HaiSheng Zeng +14 more
wiley +1 more source
Effect of blocking Ras signaling pathway with K-Ras siRNA on apoptosis in esophageal squamous carcinoma cells [PDF]
, 2013 ObjectiveTo study the effect of RNAi silencing of the K-Ras gene on Ras signal pathway activity in EC9706 esophageal cancer cells.MethodsEC9706 cells were treated in the following six groups: blank group (no transfection), negative control group ...
Xinjie Wang +18 more
core +1 more source
Local Anesthetics in Cancer: Mechanisms and Translational Perspectives
MedComm – Oncology, Volume 5, Issue 1, March 2026.Local anesthetics demonstrate multifaceted antitumor effects that collectively contribute to cancer suppression. Beyond canonical sodium channel blockade, these agents exert the following pharmacological actions: inhibition of tumor cell proliferation, suppression of migration and invasion, induction of proapoptotic pathways, attenuation of ...
Wan‐li Wang +4 more
wiley +1 more source