Results 41 to 50 of about 10,148 (237)

Transcriptional reprogramming strategies and miRNA-mediated regulation networks of Taxus media induced into callus cells from tissues

BMC Genomics, 2020
Background Taxus cells are a potential sustainable and environment-friendly source of taxol, but they have low survival ratios and slow grow rates. Despite these limitations, Taxus callus cells induced through 6 months of culture contain more taxol than ...
Ying Chen, Meng Zhang, Xiaofei Jin, Haoran Tao, Yamin Wang, Bo Peng, Chunhua Fu, Longjiang Yu   +7 more
doaj   +1 more source

Functional characterization of the cytochrome P450 monooxygenase CYP71AU87 indicates a role in marrubiin biosynthesis in the medicinal plant Marrubium vulgare. [PDF]

, 2019
BackgroundHorehound (Marrubium vulgare) is a medicinal plant whose signature bioactive compounds, marrubiin and related furanoid diterpenoid lactones, have potential applications for the treatment of cardiovascular diseases and type II diabetes.
Addison, J Bennett, Dhanota, Puja, Fiehn, Oliver, Karunanithi, Prema S, Tong, Shen, Zerbe, Philipp   +5 more
core   +6 more sources

Recent Research Progress in Taxol Biosynthetic Pathway and Acylation Reactions Mediated by Taxus Acyltransferases

Molecules, 2021
Taxol is one of the most effective anticancer drugs in the world that is widely used in the treatments of breast, lung and ovarian cancer. The elucidation of the taxol biosynthetic pathway is the key to solve the problem of taxol supply.
Tao Wang, Lingyu Li, Weibing Zhuang, Fengjiao Zhang, Xiaochun Shu, Ning Wang, Zhong Wang   +6 more
doaj   +1 more source

Plant Cellular and Molecular Biotechnology: Following Mariotti's Steps [PDF]

, 2019
This review is dedicated to the memory of Prof. Domenico Mariotti, who significantly contributed to establishing the Italian research community in Agricultural Genetics and carried out the first experiments of Agrobacterium-mediated plant genetic ...
Caretto, Sofia, Frugis, Giovanna, Giannino, Donato, Iannelli, Maria Adelaide, Mauro, Maria Luisa, Mele, Giovanni, Nicolodi, Chiara, Paolis, Angelo De, Rugini, Eddo, Silvestri, Cristian, Sparvoli, Francesca, Testone, Giulio   +11 more
core   +1 more source

Squalestatin-induced production of taxol and baccatin in cell suspension culture of yew (Taxus baccata L.) [PDF]

, 2014
Various elicitors have already been reported to enhance the production of taxol and related taxanes. In this study, effects of a fungal metabolite, squalestatin, on production of taxol and baccatin III were studied.
Afghani, Ladan., Amini, Sayed-Asadollah., Jalalpour, Zohreh., Shabani, Leila., Sharifi-Tehrani, Majid.   +4 more
core   +1 more source

Elimination of enzymes catalysis compartmentalization enhancing taxadiene production in Saccharomyces cerevisiae

Frontiers in Bioengineering and Biotechnology, 2023
Taxadiene is an important precursor in taxol biosynthesis pathway, but its biosynthesis in eukaryotic cell factories is limited, which seriously hinders the biosynthesis of taxol.
Chenglong Zhang, Wang Chen, Tianyu Dong, Ying Wang, Mingdong Yao, Wenhai Xiao, Wenhai Xiao, Bingzhi Li   +7 more
doaj   +1 more source

Transcriptome analysis of a taxol-producing endophytic fungus Cladosporium cladosporioides MD2

AMB Express, 2018
The shortage of molecular information for taxol-producing fungi has greatly impeded the understanding of fungal taxol biosynthesis mechanism. In this study, the transcriptome of one taxol-producing endophytic fungus Cladosporium cladosporioides MD2 was ...
Li-Yun Miao, Xin-Chun Mo, Xiao-Yuan Xi, Lan Zhou, Ge De, You-Sheng Ke, Pan Liu, Fa-Jun Song, Wen-Wen Jin, Peng Zhang   +9 more
doaj   +1 more source

From flavors and pharmaceuticals to advanced biofuels: Production of isoprenoids in Saccharomyces cerevisiae [PDF]

, 2013
Isoprenoids denote the largest group of chemicals in the plant kingdom and are employed for a wide range of applications in the food and pharmaceutical industry.
Ajikumar, Asadollahi, Basson, Boghigian, Bohlmann, Chang, Chappell, Cheng, Christensen, Collins, Croteau, Da Silva, Daum, Dugar, Dunlop, Engels, Farhi, Faulkner, Greenhagen, Harvey, Hong, Hu, Huang, Hui, Kampranis, Katsuki, Keasling, Kim, Kim, Krivoruchko, Lange, Lees, Li, Lurie, Lynen, Lücker, Mannan, Meigs, Michereff, Muramatsu, Murray, Murugesan, Naigre, Nielsen, Ohto, Oliveira, Oud, Pare, Partow, Parveen, Peralta-Yahya, Rohmer, Rude, Scalcinati, Scalcinati, Schiff, Sharon-Asa, Shearer, Song, Takahashi, Tracy, Tsuruta, Tu, Uribe, Wang, Wang, Wang, Westfall, Wilson, Yoshikuni, Zhang   +70 more
core   +2 more sources

Recent Advances in Metabolic Engineering, Protein Engineering, and Transcriptome-Guided Insights Toward Synthetic Production of Taxol

Frontiers in Bioengineering and Biotechnology, 2021
The diterpenoid paclitaxel (Taxol®) is a blockbuster anticancer agent that was originally isolated from the Pacific yew (Taxus brevifolia) five decades ago.
Ishmael Mutanda, Jianhua Li, Fanglin Xu, Fanglin Xu, Fanglin Xu, Yong Wang   +5 more
doaj   +1 more source

Transcriptome Sequencing Reveals Regulatory Mechanisms of Taxol Synthesis in Taxus wallichiana var. Mairei

International Journal of Genomics, 2019
Taxol is one of the most potent and effective anticancer drugs and is originally isolated from Taxus species. To investigate the specific regulatory mechanisms of taxol synthesis in Taxus wallichiana var.
Tao Wang, Yiming Chen, Weibing Zhuang, Fengjiao Zhang, Xiaochun Shu, Zhong Wang, Qing Yang   +6 more
doaj   +1 more source