Results 51 to 60 of about 327,793 (259)

Purification and Biochemical Characterization of Taxadiene Synthase from Bacillus koreensis and Stenotrophomonas maltophilia

Scientia Pharmaceutica, 2021
Taxadiene synthase (TDS) is the rate-limiting enzyme of Taxol biosynthesis that cyclizes the geranylgeranyl pyrophosphate into taxadiene. Attenuating Taxol productivity by fungi is the main challenge impeding its industrial application; it is possible ...
Ashraf S. A. El-Sayed, Maher Fathalla, Ahmed A. Shindia, Amgad M. Rady, Ashraf F. El-Baz, Yara Morsy, Basel Sitohy, Mahmoud Sitohy   +7 more
doaj   +1 more source

Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design. [PDF]

, 2011
The relaxed complex scheme, a virtual-screening methodology that accounts for protein receptor flexibility, was used to identify a low-micromolar, non-bisphosphonate inhibitor of farnesyl diphosphate synthase.
Cao, Rong, Durrant, Jacob D, Gorfe, Alemayehu A, Li, Jikun, McCammon, J Andrew, Oldfield, Eric, Sankovsky, Anna, Zhu, Wei   +7 more
core   +2 more sources

Transcriptional profile of Taxus chinensis cells in response to methyl jasmonate

BMC Genomics, 2012
Background Methyl jasmonate (MeJA) has been successfully used as an effective elicitor to enhance production of taxol and other taxanes in cultured Taxus cells. However the mechanism of MeJA-mediated taxane biosynthesis remains unclear.
Li Shu-tao, Zhang Peng, Zhang Meng, Fu Chun-hua, Zhao Chun-fang, Dong Yan-shan, Guo An-yuan, Yu Long-jiang   +7 more
doaj   +1 more source

Endophytic Fungi: Key Insights, Emerging Prospects, and Challenges in Natural Product Drug Discovery

Microorganisms, 2022
Plant-associated endophytes define an important symbiotic association in nature and are established bio-reservoirs of plant-derived natural products. Endophytes colonize the internal tissues of a plant without causing any disease symptoms or apparent ...
Pragya Tiwari, Hanhong Bae
doaj   +1 more source

Human GM3 Synthase Attenuates Taxol-Triggered Apoptosis Associated with Downregulation of Caspase-3 in Ovarian Cancer Cells [PDF]

, 2012
BACKGROUND: Taxol (paclitaxel) inhibits proliferation and induces apoptosis in a variety of cancer cells, but it also upregulates cytoprotective proteins and/or pathways that compromise its therapeutic efficacy.
Bijangi-Vishehsaraei, Khadijeh, Huang, Su, Saadatzadeh, Mohammad Reza, Safa, Ahmad R.   +3 more
core   +1 more source

Transcriptome Assembly and Systematic Identification of Novel Cytochrome P450s in Taxus chinensis

Frontiers in Plant Science, 2017
Taxus spp. is a highly valuable medicinal plant with multiple pharmacological effects on various cancers. Cytochrome P450s (CYP450s) play important roles in the biosynthesis of active compounds in Taxus spp., such as the famous diterpenoid, Taxol ...
Weifang Liao, Shengying Zhao, Meng Zhang, Kaige Dong, Ying Chen, Chunhua Fu, Chunhua Fu, Longjiang Yu, Longjiang Yu   +8 more
doaj   +1 more source

Fungal Endophytes as Efficient Sources of Plant-Derived Bioactive Compounds and Their Prospective Applications in Natural Product Drug Discovery: Insights, Avenues, and Challenges

Microorganisms, 2021
Fungal endophytes are well-established sources of biologically active natural compounds with many producing pharmacologically valuable specific plant-derived products.
Archana Singh, Dheeraj K. Singh, Ravindra N. Kharwar, James F. White, Surendra K. Gond   +4 more
doaj   +1 more source

Decreased glutathione biosynthesis contributes to EGFR T790M-driven erlotinib resistance in non-small cell lung cancer [PDF]

, 2016
Epidermal growth factor receptor (EGFR) inhibitors such as erlotinib are novel effective agents in the treatment of EGFR-driven lung cancer, but their clinical impact is often impaired by acquired drug resistance through the secondary T790M EGFR mutation.
Chater, E, De Bruin, E, Downward, J, Heynen, GJJE, Hu, Y, Li, H, Liu, Z, Pardo, OE, Roy, R, Seckl, MJS, Smit, EF, Stokes, W, Tang, H, Wang, Y   +13 more
core   +2 more sources

Darkness: A Crucial Factor in Fungal Taxol Production

Frontiers in Microbiology, 2018
Fungal Taxol acquired lots of attention in the last few decades mainly because of the hope that fungi could be manipulated more easily than yew trees to scale up the production level of this valuable anticancer drug.
Sameh S. M. Soliman, Sameh S. M. Soliman, Sameh S. M. Soliman, Manish N. Raizada   +3 more
doaj   +1 more source

Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora.

PLoS ONE, 2019
Salicylic acid (SA) is an effective elicitor to increase taxol production in Pestalotiopsis microspora. Addition of SA at the concentration of 300 μM yielded taxol 625.47 μg L-1, 45- fold higher than that of the control.
Kamalraj Subban, Ramesh Subramani, Vishnu Priya Madambakkam Srinivasan, Muthumary Johnpaul, Jayabaskaran Chelliah   +4 more
doaj   +1 more source