Results 71 to 80 of about 327,793 (259)

Enhanced anticancer activity of a combination of docetaxel and Aneustat (OMN54) in a patient-derived, advanced prostate cancer tissue xenograft model. [PDF]

, 2013
The current first-line treatment for advanced metastatic prostate cancer, i.e. docetaxel-based therapy, is only marginally effective. The aim of the present study was to determine whether such therapy can be improved by combining docetaxel with Aneustat (
Collins, Colin C, Gao, Allen C, Gout, Peter W, Liu, Chengfei, Qu, Sifeng, Wang, Kendric, Wang, Yuwei, Wang, Yuzhuo, Wu, Rebecca, Xue, Hui   +9 more
core   +1 more source

Natural Products in Cancer Prevention and Therapy: Current Challenges and Future Directions

MedComm, Volume 7, Issue 2, February 2026.
Natural products play a pivotal role in cancer therapy. They induce cancer cell death by reprogramming four metabolic pathways while precisely targeting the tumor microenvironment and immune cells. These compounds not only leverage novel delivery systems for innovative applications but also demonstrate unique therapeutic efficacy across clinical stages:
Ruimiao Qian, Jun Ge, Ni Fan, Zheng Sun, Chengcheng Zhao, Yujiao Sun, Yingpeng Li, Yunfei Li, Hui Fu   +8 more
wiley   +1 more source

ChemInform Abstract: Biosynthesis of Taxol

ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
openaire   +2 more sources

Selection and validation of reference genes for quantitative gene expression normalization in Taxus spp.

Scientific Reports, 2020
Quantitative real-time PCR (qRT-PCR) is commonly used to measure gene expression to further explore gene function, while suitable reference genes must be stably expressed under different experimental conditions to obtain accurate and reproducible data ...
Kaikai Zhang, Wei Fan, Duanfen Chen, Luyuan Jiang, Yunfeng Li, Zhiwang Yao, Yanfang Yang, Deyou Qiu   +7 more
doaj   +1 more source

Targeted control of supporting pathways in paclitaxel biosynthesis with CRISPR-guided methylation

Frontiers in Bioengineering and Biotechnology, 2023
Introduction: Plant cell culture biomanufacturing is rapidly becoming an effective strategy for production of high-value plant natural products, such as therapeutic proteins and small molecules, vaccine adjuvants, and nutraceuticals.
Cassandra Brzycki Newton, Eric M. Young, Susan C. Roberts   +2 more
doaj   +1 more source

Proteomic identification of prognostic tumour biomarkers, using chemotherapy-induced cancer-associated fibroblasts [PDF]

, 2017
Cancer cells grow in highly complex stromal microenvironments, which through metabolic remodelling, catabolism, autophagy and inflammation nurture them and are able to facilitate metastasis and resistance to therapy.
Győrffy, Balázs, Lisanti MP, Peiris-Pagès M, Smith DL, Sotgia F   +4 more
core  

Accessing low-oxidation state taxanes: is taxadiene-4(5)-epoxide on the taxol biosynthetic pathway? [PDF]

, 2016
We have shown for the first time that taxadiene (3) can be epoxidised in a regio- and diastereoselective manner to provide taxadiene-4(5)-epoxide (12) as a single diastereoisomer, and that this epoxide can be rearranged to give taxa-4(20),11(12)-dien-5α ...
Adam, Ajikumar, Angelis, Barbosa Sousa, Braude, Cragg, Danishefsky, DeJong, Doi, Edgar, Engels, Groves, Hanzlik, Hefner, Holton, Holton, Holton, Huang, Huang, Huang, Ishihara, Jennewein, Kingston, Koepp, Kovacs, Köksal, Liebler, Maruoka, Mendoza, Morihira, Mukaiyama, Murakami, Nicolaou, Parker, Rontein, Rubenstein, Traylor, Uroos, Wang, Wani, Wender, Wilde, Yadav, Yasuda   +43 more
core   +1 more source

Protein engineering strategies to optimise recombinant product synthesis and accumulation in Nicotiana benthamiana

Plant Biotechnology Journal, Volume 24, Issue 1, Page 31-43, January 2026.
Summary In plant molecular farming, recombinant products include traditional protein targets, such as antibodies, antigens, and enzymes, but also increasingly refers to high‐value peptides, and small molecules produced by heterologous enzymatic pathways.
Maxim D. Harding, Frank Sainsbury
wiley   +1 more source

Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol

Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.
A highly stereoselective, dynamic reductive kinetic resolution (DYRKR) entry into myriad Taxotere‐like side chains with Clostridium acetobutylicum alcohol dehydrogenase (CaADH) enzyme is reported. Follow‐on cross couplings expand the structural diversity of the library (36 total examples).
Gaurav P. Kudalkar, Florian Leidner, Nivesh Kumar, Jared L. Hass, Peter Madzelan, Douglas R. Powell, Victor W. Day, Pierre Le Magueres, Joseph D. Ferrara, Lee M. Daniels, Akihito Yamano, Sho Ito, Wei Niu, Helmut Grubmüller, Mark A. Wilson, David B. Berkowitz   +15 more
wiley   +2 more sources

Plant cell and organ cultures as a source of phytochemicals [PDF]

, 2015
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/67430Plant cell and organ cultures constitute a promising platform for the production of numerous valuable secondary compounds.
Bonfill Baldrich, Ma. Mercedes, Cusidó Vidal, Rosa M., Lalaleo, Liliana, Palazón Barandela, Javier   +3 more
core