Results 151 to 160 of about 2,363,919 (190)
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Phase I Study of CBT-1™ and Taxol® in Patients with Taxol® Resistant Cancers
Cancer Biotherapy and Radiopharmaceuticals, 2000CBT-1, a natural product, was studied as an MDR modulator with Taxol (135 mg/m2) in an escalating dose Phase I clinical trial. CBT-1 was administered orally at doses from 300 mg/m2 to 500 mg/m2 daily x 7. The MTD was determined to be 500 mg/m2 with moderate nausea and occasional emesis.
R K, Oldham, W K, Reid, D, Barnett
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Food FrontiersDrug resistance in non‐small cell lung cancer (NSCLC) limits its therapeutic efficacy. Allicin may help to solve the problem of Taxol resistance in NSCLC.
Qing-Chun Zhao +2 more
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Biochemical and Biophysical Research Communications, 2020
Taxol resistance led to the poor survival prognosis in advanced nasopharyngeal carcinoma (NPC). Epithelial-mesenchymal transition (EMT) plays an important role in tumor chemoresistance. Neferine (NEF) is found to sensitize the cancer cells to chemotherapeutic agents, but its effects and mechanisms on NPC Taxol resistance is unclear.
Xianyao, Wang +4 more
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Taxol resistance led to the poor survival prognosis in advanced nasopharyngeal carcinoma (NPC). Epithelial-mesenchymal transition (EMT) plays an important role in tumor chemoresistance. Neferine (NEF) is found to sensitize the cancer cells to chemotherapeutic agents, but its effects and mechanisms on NPC Taxol resistance is unclear.
Xianyao, Wang +4 more
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Molecular and General Genetics MGG, 1999
The anti-cancer drug taxol binds to beta-tubulin in assembled microtubules and causes cell cycle arrest in animal cells; in contrast, in fungi, the effect of taxol varies. For instance, the taxol-producer Pestalotiopsis microspora Ne32, an ascomycete, is resistant to taxol (IC50 greater than 11.7 microM), whereas Pythium ultimum, an oomycete, is ...
J H, Mu, A P, Bollon, R S, Sidhu
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The anti-cancer drug taxol binds to beta-tubulin in assembled microtubules and causes cell cycle arrest in animal cells; in contrast, in fungi, the effect of taxol varies. For instance, the taxol-producer Pestalotiopsis microspora Ne32, an ascomycete, is resistant to taxol (IC50 greater than 11.7 microM), whereas Pythium ultimum, an oomycete, is ...
J H, Mu, A P, Bollon, R S, Sidhu
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Taxol: mechanisms of action and resistance.
Journal of the National Cancer Institute. Monographs, 1994Information on the mechanisms of action and of resistance to Taxol, as well as new data from our laboratory on the promoter regions of the genes that encode P-glycoprotein in a murine Taxol-resistant cell line, is discussed. Taxol induces the formation of stable bundles of microtubules, thereby interfering with the normal function of cellular ...
S B, Horwitz +5 more
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Treatment of Resistant Gestational Choriocarcinoma with Taxol: A Report of Two Cases
Gynecologic Oncology, 1996Two patients with resistant gestational choriocarcinoma were treated w with Taxol after extensive prior chemotherapy including EMACO and platinum-based salvage chemotherapy. Both patients showed significant responses to Taxol. One patient relapsed in the brain and liver after treatment and died.
W B, Jones +3 more
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Role of DDX53 in taxol-resistance of cervix cancer cells in vitro
Biochemical and Biophysical Research Communications, 2018Cancer/Testis antigen DDX53 shows high expression level in various tumors and is involved in anti-cancer drug resistance. However, the functional study of DDX53 in cervix cancer remains unknown. In this study, the role of DDX53 in taxol-resistance of cervix cancer cells was investigated.
Su Yeon Park +6 more
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Paclitaxel (Taxol) Resistance in Breast Cancer Cells.
1996Abstract : A paclitaxel resistant cell line, KPTA5, was established by co-selecting the parental cell line K562 with step-wise increased concentrations of paclitaxel (Taxol%) in the presence of the cyclosporin D analogue PSC 833 (2 %M), a potent modulator of the multidrug resistance phenotype. KPTA5 cells are 9-fold resistant to paclitaxel and taxotere,
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Cancer Chemotherapy and Pharmacology, 1999
Eleutherobin, a natural product, is an antimitotic agent that promotes the polymerization of stable microtubules. Although its mechanism of action is similar to that of Taxol, its structure is distinct. A structure-activity profile of synthetic eleutherobin derivatives that have modifications at C3, C8 and C15 was undertaken to define the structural ...
H M, McDaid +7 more
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Eleutherobin, a natural product, is an antimitotic agent that promotes the polymerization of stable microtubules. Although its mechanism of action is similar to that of Taxol, its structure is distinct. A structure-activity profile of synthetic eleutherobin derivatives that have modifications at C3, C8 and C15 was undertaken to define the structural ...
H M, McDaid +7 more
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Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2013
To compare the difference in gene expression profiles between parental cell line and drug resistant cell line (CNE-1 and CNE-1/taxol) pre-treated or treated by drugs, and search for genes related to taxol resistance and reversal of taxol resistance phenotype.cDNA microarray was used to detect the difference in gene expression profiles between 6 groups ...
Xiaowei, Peng, Guolin, Tan
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To compare the difference in gene expression profiles between parental cell line and drug resistant cell line (CNE-1 and CNE-1/taxol) pre-treated or treated by drugs, and search for genes related to taxol resistance and reversal of taxol resistance phenotype.cDNA microarray was used to detect the difference in gene expression profiles between 6 groups ...
Xiaowei, Peng, Guolin, Tan
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