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Phase I Study of CBT-1™ and Taxol® in Patients with Taxol® Resistant Cancers
Cancer Biotherapy and Radiopharmaceuticals, 2000CBT-1, a natural product, was studied as an MDR modulator with Taxol (135 mg/m2) in an escalating dose Phase I clinical trial. CBT-1 was administered orally at doses from 300 mg/m2 to 500 mg/m2 daily x 7. The MTD was determined to be 500 mg/m2 with moderate nausea and occasional emesis.
R K, Oldham, W K, Reid, D, Barnett
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Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cells [PDF]
Oncogene, 2004 Taxol is one of the widely used chemotherapeutic drugs against many types of human cancer. While it is considered as one of the most effective anticancer drugs, treatment failure often occurs due to development of acquired resistance.
, Yim Ling Yip, Guan Xin-Yuan
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Biochemical and Biophysical Research Communications, 2020
Taxol resistance led to the poor survival prognosis in advanced nasopharyngeal carcinoma (NPC). Epithelial-mesenchymal transition (EMT) plays an important role in tumor chemoresistance. Neferine (NEF) is found to sensitize the cancer cells to chemotherapeutic agents, but its effects and mechanisms on NPC Taxol resistance is unclear.
Xianyao, Wang +4 more
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Taxol resistance led to the poor survival prognosis in advanced nasopharyngeal carcinoma (NPC). Epithelial-mesenchymal transition (EMT) plays an important role in tumor chemoresistance. Neferine (NEF) is found to sensitize the cancer cells to chemotherapeutic agents, but its effects and mechanisms on NPC Taxol resistance is unclear.
Xianyao, Wang +4 more
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Molecular and General Genetics MGG, 1999
The anti-cancer drug taxol binds to beta-tubulin in assembled microtubules and causes cell cycle arrest in animal cells; in contrast, in fungi, the effect of taxol varies. For instance, the taxol-producer Pestalotiopsis microspora Ne32, an ascomycete, is resistant to taxol (IC50 greater than 11.7 microM), whereas Pythium ultimum, an oomycete, is ...
J H, Mu, A P, Bollon, R S, Sidhu
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The anti-cancer drug taxol binds to beta-tubulin in assembled microtubules and causes cell cycle arrest in animal cells; in contrast, in fungi, the effect of taxol varies. For instance, the taxol-producer Pestalotiopsis microspora Ne32, an ascomycete, is resistant to taxol (IC50 greater than 11.7 microM), whereas Pythium ultimum, an oomycete, is ...
J H, Mu, A P, Bollon, R S, Sidhu
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Autotaxin, lysophosphatidate and taxol resistance
2009First-line treatment of breast and other cancers with Taxol is compromised by resistance in up to 40% of patients. To improve chemotherapy, it is vital to understand how Taxol resistance develops and to overcome this. Autotaxin (ATX) promotes cancer cell survival, growth, migration, invasion and metastasis.
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Taxol: mechanisms of action and resistance.
Journal of the National Cancer Institute. Monographs, 1994Information on the mechanisms of action and of resistance to Taxol, as well as new data from our laboratory on the promoter regions of the genes that encode P-glycoprotein in a murine Taxol-resistant cell line, is discussed. Taxol induces the formation of stable bundles of microtubules, thereby interfering with the normal function of cellular ...
S B, Horwitz +5 more
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Treatment of Resistant Gestational Choriocarcinoma with Taxol: A Report of Two Cases
Gynecologic Oncology, 1996Two patients with resistant gestational choriocarcinoma were treated w with Taxol after extensive prior chemotherapy including EMACO and platinum-based salvage chemotherapy. Both patients showed significant responses to Taxol. One patient relapsed in the brain and liver after treatment and died.
W B, Jones +3 more
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Role of DDX53 in taxol-resistance of cervix cancer cells in vitro
Biochemical and Biophysical Research Communications, 2018Cancer/Testis antigen DDX53 shows high expression level in various tumors and is involved in anti-cancer drug resistance. However, the functional study of DDX53 in cervix cancer remains unknown. In this study, the role of DDX53 in taxol-resistance of cervix cancer cells was investigated.
Su Yeon Park +6 more
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Paclitaxel (Taxol) Resistance in Breast Cancer Cells.
1996Abstract : A paclitaxel resistant cell line, KPTA5, was established by co-selecting the parental cell line K562 with step-wise increased concentrations of paclitaxel (Taxol%) in the presence of the cyclosporin D analogue PSC 833 (2 %M), a potent modulator of the multidrug resistance phenotype. KPTA5 cells are 9-fold resistant to paclitaxel and taxotere,
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The characteristics of Hep‐2 cell with multiple drug resistance induced by Taxol
Otolaryngology–Head and Neck Surgery, 2007ObjectivesTo investigate the characteristics of Hep‐2 cell with multidrug resistance (MDR) induced by Taxol.Study DesignHep‐2 cells were exposed in stepwise escalating concentration of Taxol to develop the resistant cell line‐Hep‐2T. Cell cycle distribution, apoptosis, and rhodamine accumulation were studied through flow cytometry.
Li, Li +4 more
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