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Antitumor effect of taxol-containing liposomes in a taxol-resistant murine tumor model.
Cancer research, 1994Taxol is a promising agent for use in ovarian cancer and other malignancies. One problem associated with taxol is its low aqueous solubility, requiring Cremophor EL (polyethoxylated castor oil) and ethanol as excipients (Diluent 12); these agents cause serious adverse effects.
A, Sharma, E, Mayhew, R M, Straubinger
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[Development of research for drug-resistance mechanism of taxol].
Ai zheng = Aizheng = Chinese journal of cancer, 2003The resistant problem is the main restriction factor for clinical usage of taxol. The main mechanism of its resistance includes the high expression of P-gp, beta- and alpha-tubulin isotypes, the alteration expression of PKC, Bcl-2, p53, and ErbB2. The reversing method includes the use of analogues of taxol to reduce the expression of P-gp, or the use ...
Fang, Wang, Rui, Han
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New Agents for Taxol-Resistant Breast Adenocarcinoma
2003Abstract : Taxol has proven to be a valuable addition to the chemotherapeutic regimens that can be offered to breast cancer patients; however, as with other drugs, evidence for resistance to Taxol has emerged. Among these resistance mechanisms is the P-gp 170 membrane-associated drug-efflux pump, for which the active agent, paclitaxel, is a substrate ...
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TLR4 and NFκB signaling is critical for taxol resistance in ovarian carcinoma cells
Journal of Cellular Physiology, 2017We report here that toll‐like receptor 4 (TLR4) and ABCB1 are upregulated in SKOV3 ovarian carcinoma cells that acquired resistance to the anticancer drug taxol. Silencing of TLR4 using short‐hairpin RNA sensitized taxol‐resistant SKOV3 cells to taxol (4.6 fold), whereas ectopic expression of TLR4 in parental, taxol‐sensitive SKOV3 cells or TLR4‐null ...
Nian‐Kang Sun +3 more
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New Agents for Taxol-Resistant Ovarian Carcinoma
2002Abstract : Taxol resistance is an important issue in relapsing ovarian cancer. Two approaches to address this resistance include the use of drug copolymers and drug targeting. In this proposal, paclitaxel covalently coupled to backbones of poly(L-glutamic) acid (non- targeted) or hyaluronic acid (CD44 targeted) as prodrugs will be evaluated in CD44 ...
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The characteristics of Hep‐2 cell with multiple drug resistance induced by Taxol
Otolaryngology–Head and Neck Surgery, 2007ObjectivesTo investigate the characteristics of Hep‐2 cell with multidrug resistance (MDR) induced by Taxol.Study DesignHep‐2 cells were exposed in stepwise escalating concentration of Taxol to develop the resistant cell line‐Hep‐2T. Cell cycle distribution, apoptosis, and rhodamine accumulation were studied through flow cytometry.
Li, Li +4 more
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A phosphoglycoprotein associated with taxol resistance in J774.2 cells.
Cancer research, 1985Taxol is an inhibitor of cell replication that promotes the assembly of microtubules in vitro and in cells. In the murine macrophage-like cell line J774.2, a taxol-resistant subline (J7/TAX-50) has been developed in vitro by growing the cells in increasing drug concentrations.
S N, Roy, S B, Horwitz
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Phorbol myristate induces apoptosis of taxol-resistant sarcoma cells in vitro
European Journal of Pharmacology, 2004Taxol was found to induce polyploidization and apoptosis in cultured methylcholanthrene-induced sarcoma cells (Meth-A cells), but some of the cells in G1 phase were not affected. We refer to these cells as taxol-resistant cells. Phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) regulator, was used to test the taxol-resistant cells.
Zhi-ping, Zong +4 more
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Taxol Resistance and Microtubule Dynamics in Breast Cancer
2002Abstract : Alterations to microtubule dynamics, leading to a less stable polymer, may be a crucial determinant in the development of resistance towards Taxol, and other drugs with a binding site on the microtubule polymer. We propose that two potential mechanisms by which breast cancer cells could alter their microtubule dynamics are by (1 ...
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Linking the immunophilin FKBP5 to taxol resistance in ovarian cancer
Cancer Cell & Microenvironment, 2015Taxol is a chemotherapeutic drug used to treat a number of cancers, including ovarian and breast cancers. However, taxol resistance limits treatment efficacy in cancer patients. To study the molecular mechanism of chemoresistance in ovarian cancer, we established taxol-resistant cells derived from the SKOV3 ovarian carcinoma cell lineage ...
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