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Suppression of Glucosylceramide Synthase Reverses Drug Resistance in Cancer Cells Harboring Homozygous p53 Mutants. [PDF]
Int J Mol SciMostaq MS +10 more
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Intracellular Self‐Assembly of Taxol Nanoparticles for Overcoming Multidrug Resistance
Angewandte Chemie - International Edition, 2015AbstractMultidrug resistance (MDR) remains the biggest challenge in treating cancers. Herein we propose the intracellular self‐assembly of nanodrugs as a new strategy for overcoming MDR. By employing a biocompatible condensation reaction, we rationally designed a taxol derivative Ac‐Arg‐Val‐Arg‐Arg‐Cys(StBu)‐Lys(taxol)‐2‐cyanobenzothiazole (CBT‐Taxol ...
Huafeng Zhang, Linna An, Yue Yuan
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Chemotherapy, 2000
<i>Background:</i> Taxol has gained considerable attention in cancer therapy in recent years and is successfully used in treating a variety of tumors, including those of the breast, ovary and lung. Despite its preclinical and clinical success, the ability of tumors to develop an acquired resistance to drugs used for treatment remains a ...
S, Sangrajrang, A, Fellous
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<i>Background:</i> Taxol has gained considerable attention in cancer therapy in recent years and is successfully used in treating a variety of tumors, including those of the breast, ovary and lung. Despite its preclinical and clinical success, the ability of tumors to develop an acquired resistance to drugs used for treatment remains a ...
S, Sangrajrang, A, Fellous
openaire +2 more sources
Carboplatin and taxol resistance develops more rapidly in functional BRCA1 compared to dysfunctional BRCA1 ovarian cancer cells [PDF]
Experimental Cell Research, 2015 A major risk factor for ovarian cancer is germline mutations of BRCA1/2. It has been found that (80%) of cellular models with acquired platinum or taxane resistance display an inverse resistance relationship, that is collateral sensitivity to the other ...
John O'Leary +2 more
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Anti‐apoptotic role of TWIST and its association with Akt pathway in mediating taxol resistance in nasopharyngeal carcinoma cells [PDF]
International Journal of Cancer, 2007 TWIST, a basic helix-loop-helix transcription factor, has been reported to be associated with development and progression of human cancer. Recently, over expression of TWIST is found in cancer patients with shorter survival and poor response to ...
Leung, SCL +5 more
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Paclitaxel (Taxol®) Mechanisms of Resistance
1996Paclitaxel (Taxol #®) is one of the most promising new anticancer agents developed in recent years [1]. Taxol® has been approved for the treatment of refractory ovarian [2,3] and breast cancer [4] in several countries, and has shown activity against after human malignancies, such as lung cancer head and neck cancer, esophageal cancer, hematological ...
A M, Casazza, C R, Fairchild
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Taxol Is Active in Platinum-Resistant Endometrial Adenocarcinoma
American Journal of Clinical Oncology, 1996Taxol, 170 mg/m2 by 3-h infusion every 3 weeks, was administered to seven patients with primarily advanced or recurrent endometrial cancer with progressive disease on platinum analogues. By standard response criteria, there were three clinical responders (43%; 95% confidence limits, 6-80%) and one disease stabilization.
H L, Woo, K D, Swenerton, P J, Hoskins
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