Results 181 to 190 of about 13,784 (200)

Phorbol myristate induces apoptosis of taxol-resistant sarcoma cells in vitro

European Journal of Pharmacology, 2004
Taxol was found to induce polyploidization and apoptosis in cultured methylcholanthrene-induced sarcoma cells (Meth-A cells), but some of the cells in G1 phase were not affected. We refer to these cells as taxol-resistant cells. Phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) regulator, was used to test the taxol-resistant cells.
Zhi-ping, Zong, Shinobu, Matsui, Shogo, Katsuda, Jian-feng, Han, Kohzaburo, Fujikawa-Yamamoto   +4 more
openaire   +2 more sources

Linking the immunophilin FKBP5 to taxol resistance in ovarian cancer

Cancer Cell & Microenvironment, 2015
Taxol is a chemotherapeutic drug used to treat a number of cancers, including ovarian and breast cancers. However, taxol resistance limits treatment efficacy in cancer patients. To study the molecular mechanism of chemoresistance in ovarian cancer, we established taxol-resistant cells derived from the SKOV3 ovarian carcinoma cell lineage ...
openaire   +1 more source

Antagonism of Taxol Cytotoxicity by Prolactin: Implication for Patient Resistance to Chemotherapy

2007
Abstract : The objective of this investigation is to examine the protective effects of prolactin (PRL) against anti-cancer drugs. Three specific aims were formulated: 1) To characterize the protective effects of PRL against several anticancer drugs, 2) To determine anti-apoptotic mechanism(s), and 3) To examine the protective effects of PRL in vivo ...
openaire   +1 more source

Taxol: Mechanisms of Action and Resistancea

Annals of the New York Academy of Sciences, 1986
S B, Horwitz, L, Lothstein, J J, Manfredi, W, Mellado, J, Parness, S N, Roy, P B, Schiff, L, Sorbara, R, Zeheb   +8 more
openaire   +2 more sources

7 The biochemical pharmacology of taxol® and mechanisms of resistance

1995
Publisher Summary This chapter describes biochemical pharmacology of Taxol ® and its mechanisms of resistance. Microtubules, like DNA and RNA, are conserved structures in all eukaryotic cells with numerous and diverse functions. By forming a scaffolding network within cells, microtubules maintain cell shape.
openaire   +1 more source

Inhibition of STAT3 reverses Taxol-resistance in ovarian cancer by down-regulating G6PD expression in vitro

Biochemical and Biophysical Research Communications, 2022
Xiugui Sheng, Peng Zhang
exaly  

Differential expression of mRNAs in a taxol-resistant ovarian cancer cell line grown in the presence of taxol

Journal of the Society for Gynecologic Investigation, 1998
L GREGOIRE, A MUNKARAH, R MORRIS, Y MIN, W LANCASTER   +4 more
openaire   +1 more source

Acquisition of taxol resistance via P-glycoprotein- and non-P-glycoprotein-mediated mechanisms in human ovarian carcinoma cells

Biochemical Pharmacology, 1997
Hemant Parekh, Henry Simpkins
exaly  

Mechanistic Analysis of Taxol-induced Multidrug Resistance in an Ovarian Cancer Cell Line

Asian Pacific Journal of Cancer Prevention, 2013
Li-Jun Zhao
exaly  

Inhibition of α Folate Receptor Resulting in a Reversal of Taxol Resistance in Nasopharyngeal Carcinoma

Otolaryngology - Head and Neck Surgery, 2012
Guolin Tan, Heqing Li
exaly