Results 151 to 160 of about 2,026,427 (351)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Functional and Taxonomic Diversity of Anaerobes in Supraglacial Microbial Communities. [PDF]

Microbiol Spectr, 2023
Pittino F, Zawierucha K, Poniecka E, Buda J, Rosatelli A, Zordan S, Azzoni RS, Diolaiuti G, Ambrosini R, Franzetti A.   +9 more
europepmc   +1 more source

Appendix H. Estimated coefficients of explanatory parameters in the best generalized linear mixed model (GLMM) for richness and diversity (the inverse Simpson’s index of diversity) of butterfly and Orthopteran taxonomic group in 2011 and 2012, and a figure for relationships of species richness of herbivorous insects of taxonomic groups with resource of perennial plant variables and mowing frequency.

, 2016
Kei Uchida, Atushi Ushimaru
openalex   +1 more source

Taxonomic and functional diversity of mollusk assemblages in a tropical rocky intertidal zone [PDF]

, 2020
Shayanna M. A. da R. Souza, Helena Matthews-Cascón, Erminda da Conceição Guerreiro Couto   +2 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

A review of the taxonomic diversity, host-parasite interactions, and experimental research on chytrids that parasitize diatoms. [PDF]

Front Microbiol, 2023
Danz A, Quandt CA.
europepmc   +1 more source

Appendix C. Analysis of covariance model for the relationship between mode of regeneration, taxonomic family, and extant density of plant species, with estimated canopy seed store size per plant as covariate, for four high-diversity shrubland sites near Eneabba, southwestern Australia.

, 2016
Neal J. Enright, Eva Mosner, Ben P. Miller, Nancy Collins Johnson, Byron B. Lamont   +4 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Silent changes in taxonomic, functional and phylogenetic diversity of birds in Qiyunshan National Nature Reserve, south China [PDF]

Binqiang Li, Jian Lü, Xin Zhong, Dongying Li, Bailin Li, Nehafta Bibi, Kechuan Linghu, Shanjun Ma, Pinghua Zhong   +8 more
openalex   +1 more source