Results 81 to 90 of about 249,034 (202)

Identification and characterization of the TCA cycle genes in maize

BMC Plant Biology, 2019
Background The tricarboxylic acid (TCA) cycle is crucial for cellular energy metabolism and carbon skeleton supply. However, the detailed functions of the maize TCA cycle genes remain unclear.
Yongming Liu, Jingtao Qu, Ling Zhang, Xiangyu Xu, Gui Wei, Zhuofan Zhao, Maozhi Ren, Moju Cao   +7 more
doaj   +1 more source

High-to-low CO2 acclimation reveals plasticity of the photorespiratory pathway and indicates regulatory links to cellular metabolism of Arabidopsis [PDF]

, 2012
Background: Photorespiratory carbon metabolism was long considered as an essentially closed and nonregulated pathway with little interaction to other metabolic routes except nitrogen metabolism and respiration. Most mutants of this pathway cannot survive
Alisdair, R.F., Bauwe, H., Dreissen, A., Fernie, A.R., Florian, A., Frankenbach, S., Hocken, N., Mielewczik, M., Timm, S., Walter, A.   +9 more
core   +4 more sources

Systems biology analysis of drivers underlying hallmarks of cancer cell metabolism. [PDF]

, 2017
Malignant transformation is often accompanied by significant metabolic changes. To identify drivers underlying these changes, we calculated metabolic flux states for the NCI60 cell line collection and correlated the variance between metabolic states of ...
Bordbar, Aarash, Corbett, Austin J, Jamshidi, Neema, Palsson, Bernhard O, Thomas, Alex, Zielinski, Daniel C   +5 more
core   +1 more source

Metabolic coupling of ROS generation and antioxidant synthesis by the GABA shunt pathway in myeloid-like blood progenitor cells of Drosophila.

PLoS Genetics
Redox balance is crucial for normal development of stem and progenitor cells that reside in oxidative environments. In this study, we explore the mechanisms of redox homeostasis in such niches and show that myeloid-like blood progenitor cells of the ...
Manisha Goyal, Sakshi Tiwari, Jagriti Arora, Bruce Cooper, Ramaswamy Subramanian, Tina Mukherjee   +5 more
doaj   +1 more source

(13)C MRS and LC-MS Flux Analysis of Tumor Intermediary Metabolism. [PDF]

, 2016
We present the first validated metabolic network model for analysis of flux through key pathways of tumor intermediary metabolism, including glycolysis, the oxidative and non-oxidative arms of the pentose pyrophosphate shunt, the TCA cycle as well as its
Blair, Ian A., Glickson, Jerry D., Guo, Lili, Lee, Seung-Cheol, Leeper, Dennis B., Nath, Kavindra, Nelson, David S., Roman, Jeffrey C., Shestov, Alexander A., Wasik, Mariusz A.   +9 more
core   +2 more sources

The compositional and evolutionary logic of metabolism

, 2012
Metabolism displays striking and robust regularities in the forms of modularity and hierarchy, whose composition may be compactly described. This renders metabolic architecture comprehensible as a system, and suggests the order in which layers of that ...
Alberts B, Andreini C, Balche W E, Barker H A, Benner S A, Berge C, Braakman R, Brazelton W J, Buss L W, Collins M D, Copley S D, Dagley S, Darwin C, de Duve C, Doyle J, Eric Smith, Erwin D H, Feist A M, Fenchel T, Fisher R A, Fry I, Gerhart J, Gesteland R F, Gould S J, Gray H B, Guiral M, Haldane J B S, Kallen R G, Kauffman S, Kim J, Lengeler J W, Ljungdahl L, MacKenzie R E, Martin W, Massey L K, Metzler D E, Morowitz H J, Morowitz H J, Morowitz H J, Nelson D L, Nitscke W, Odling-Smee F J, Oparin A I, Petsko G A, Puigbo P, Ragsdale S, Ragsdale S W, Rankama K, Razin S, Redfield A C, Redfield A C, Rogier Braakman, Russell M J, Schrödinger E, Schuster P, Segré D, Shapiro R, Simon H A, Simon H A, Smith E, Srinivasan V, Srinivasan V, Sterner R W, Stryer L, Szent-Gyorgyi A, Tazuya K, Utter M F, Vogels G D, von Wettstein D, Vorholt J A, Waber L J, Wald G, Wilson E B, Wächtershäuser G, Yarus M, Yi L   +75 more
core   +1 more source

Metabolic Regulation of Epithelial to Mesenchymal Transition: Implications for Endocrine Cancer [PDF]

, 2019
York University ...
Bhattacharya, Debasmita, Scimè, Anthony
core   +1 more source

Fumarate Hydratase Loss Causes Combined Respiratory Chain Defects. [PDF]

, 2017
Fumarate hydratase (FH) is an enzyme of the tricarboxylic acid (TCA) cycle mutated in hereditary and sporadic cancers. Despite recent advances in understanding its role in tumorigenesis, the effects of FH loss on mitochondrial metabolism are still ...
Bridges, Hannah R, D'Santos, Clive, Frezza, Christian, Gaude, Edoardo, Griffiths, John R, Hernandez-Fernaud, Juan, Hirst, Judy, Papachristou, Evangelia K, Schreiner, Alexander, Sciacovelli, Marco, Springett, Roger, Tyrakis, Petros A, Yurkovich, Marie E   +12 more
core   +2 more sources

Formal TCA cycle description based on elementary actions

Journal of Biosciences, 2007
Many databases propose their own structure and format to provide data describing biological processes. This heterogeneity contributes to the difficulty of large systematic and automatic functional comparisons. To overcome these problems, we have used the BioPsi formal description scheme which allows multi-level representations of biological process ...
Pierre, Maziere, Parisey, N., Beurton-Aimar, M., Franck, Molina   +3 more
openaire   +3 more sources

Dysregulated Tricarboxylic Acid Cycle Metabolism Is Associated With Right Ventricular Maladaptation in Pulmonary Vascular Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Right ventricular (RV) maladaptation to elevated pulmonary afterload is the primary determinant of outcomes in pulmonary artery (PA) hypertension; however, the pathobiological mechanisms underlying RV decompensation remain poorly understood ...
Darin T. Rosen, Todd M. Kolb, Stephen C. Mathai, Karthik Suresh, Rachel Damico, Steven Hsu, Ryan J. Tedford, Anna R. Hemnes, Jane A. Leopold, Evelyn M. Horn, Erika S. Berman‐Rosenzweig, Franz Rischard, Robert P. Frantz, Serpil C. Erzurum, Gerald J. Beck, Nicholas S. Hill, John Barnard, Samar Farha, Gabriele Grunig, Christine Jellis, Deborah H. Kwon, Reena Mehra, Margaret M. Park, W. H. Wilson Tang, Paul M. Hassoun, Catherine E. Simpson   +25 more
doaj   +1 more source