Results 21 to 30 of about 13,392 (209)

TCDD promotes lung tumors via attenuation of apoptosis through activation of the Akt and ERK1/2 signaling pathways. [PDF]

PLoS ONE, 2014
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a multiple-site, multiple-species carcinogen that induces cancer in multiple organs. The molecular mechanisms underlying TCDD-induced lung tumorigenesis remain unclear.
Rong-Jane Chen, Shih-He Siao, Chung-Huei Hsu, Chu-Yung Chang, Louis W Chang, Chih-Hsiung Wu, Pinpin Lin, Ying-Jan Wang   +7 more
doaj   +1 more source

MODIFIED SNODGRASS TECHNIQUE IN DISTAL HYPOSPADIAS

Urology Research and Practice, 2019
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A. METİN, Ö. KAYIGİL, S.İ. AHMED
doaj   +2 more sources

BLADDER NECK SUSPENSION VERSUS MODIFIED INSITU VAGINAL WALL SLING IN STRESS INCONTINENCE

Urology Research and Practice, 2019
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A. METİN, Ö. KAYIGİL, S.İ. AHMED
doaj   +2 more sources

Transcriptional, hormonal and histological alterations in the ovaries of BALB/c mice exposed to TCDD in connection with multigenerational female infertility

Ecotoxicology and Environmental Safety, 2023
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic congener of dioxins, has a proven reproductive toxicity. Due to the lack of evidence on the multigenerational female reproductive toxicity of TCDD through the maternal exposure, the current study
Nour Aldeli, Chadi Soukkarie, Abdulsamie Hanano   +2 more
doaj   +1 more source

Prenatal dioxin exposure and glucose metabolism in the Seveso Second Generation study

Environment International, 2020
Background: Exposure to endocrine disrupting compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during susceptible developmental windows may alter risk of metabolic disease later in life. Animal studies of in utero and lactational TCDD exposure
Marcella Warner, Stephen Rauch, Paolo Brambilla, Stefano Signorini, Paolo Mocarelli, Brenda Eskenazi   +5 more
doaj   +1 more source

Effect Of Alpha-Tocopherol On Spermatozoa Death Of Apoptosis and Necrosis in Rats (Rattus Norvegicus) Exposed 2,3,7,8- Tetrachlorodibenzo-P-Dioxin

Journal of Stem Cell Research and Tissue Engineering, 2021
The aims of this research was to investigate effect of alpha-tocopherol on spermatozoa death in form of apoptosis and necrosis in rats (Rattus norvegicus) exposed 2,3,7,8- tetrachlorodibenzo-p-dioxin. Male rats were administered TCDD and alpha-tocopherol
Valderama Gomang
doaj   +1 more source

Microbiome‐Derived Tryptophan Metabolites Regulate AhR Signaling to Restore Epithelial Barrier Integrity in Inflammatory Bowel Disease

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
The graphical abstract illustrates how microbiome‐derived indoles activate the aryl hydrocarbon receptor to restore the intestinal barrier. The picture contrasts the “leaky gut” state with the restored homeostasis achieved through AMPK, Nrf2, and IL‐22 signaling.
Mohammad Ali Mahdiabadi, Asma Moghaddam, Nafiseh Erfanian   +2 more
wiley   +1 more source

Rapid dechlorination of 1,2,3,4-TCDD by Ag/Fe bimetallic particles

, 2015
Polychlorinated dibenzo-p-dioxins (PCDDs) are among the most concerned environmental pollutants on the priority list, and their degradation is difficult to achieve.
Wang, Zhiyuan, Huang, Weilin, Peng, Ping'an, Fennell, Donna E.   +3 more
core   +1 more source

RETROSPECTIVE EVALUATION OF 42 PATIENTS WITH URETHRAL STRICTURE WHO WERE FOLLOWED AT OUR CLINIC

Urology Research and Practice, 2019
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Ö. ATAHAN, Ö. KAYIGİL, A. METİN
doaj   +2 more sources

Tryptophan metabolism in colorectal cancer: From mechanistic insights to novel therapeutic strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Tryptophan metabolism modulates CRC via three microbiota‐regulated pathways with distinct dual‐mode effects. The kynurenine pathway provides biomarkers, serotonin pathway supports SSRI‐combined immunotherapy, indole pathway yields immunostimulatory metabolites, collectively offering translational prospects.
Ran Wang, Wenke Shen, Ping Yang, Dongxue Yang, Yuepeng Cao, Yuping Zhou   +5 more
wiley   +1 more source