Results 41 to 50 of about 7,461 (172)

Role of Protocatechuic Acid (PCA) on Hepatoxicity and Nephrotoxicity Induced by 2, 3, 7, 8-Tetracholorodibenzo-P-Dioxin (TCDD) in Rats

open access: yesDüzce Üniversitesi Bilim ve Teknoloji Dergisi, 2020
Itis known that TCDD, one of the most toxic dioxin compounds, causes oxidativedamage by forming free radical in human and animal tissues. In this study, theprotective effect of PCA, an important phenolic compound, was examined in ratkidney and liver ...
Ahmet Savcı, İlknur Özdemir
doaj   +1 more source

Dexamethasone‐Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH‐7 Cells

open access: yesFundamental &Clinical Pharmacology, Volume 40, Issue 3, May 2026.
ABSTRACT Background The application of human hepatic cell lines to early drug discovery and development instead of human primary hepatocytes (HPHs) has been limited because of the low level of drug‐metabolizing enzymes (DMEs). Objective The study aimed to evaluate the effects of dexamethasone (DEX) treatment on DME expression, activities, and ...
Hana Yu   +4 more
wiley   +1 more source

Modifying Effect of the Antibiotic Action, Membrane Permeability, and ADMET/Toxicity Profile of the Fixed Oil From the Pulp of Mauritia Flexuosa F.L. (Arecaceae)

open access: yesChemistry &Biodiversity, Volume 23, Issue 4, April 2026.
ABSTRACT The increasing bacterial resistance to antibiotics has stimulated the search for natural products capable of modulating antimicrobial activity. In this study, the fixed oil from Mauritia flexuosa pulp was evaluated for its antibacterial activity, modulatory effect on antibiotics, membrane permeability, and ADMET/toxicity profile.
Isaac Moura Araújo   +15 more
wiley   +1 more source

Prenatal exposure to TCDD and atopic conditions in the Seveso second generation: a prospective cohort study

open access: yesEnvironmental Health, 2018
Background 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a toxic environmental contaminant that can bioaccumulate in humans, cross the placenta, and cause immunological effects in children, including altering their risk of developing allergies.
Morgan Ye   +4 more
doaj   +1 more source

Risk assessment of the production of seaweed in the Netherlands; food safety and nature

open access: yesFood Risk Assess Europe, Volume 4, Issue 2, April 2026.
Abstract Seaweed is seen as an important source of alternative proteins for a sustainable food system and food security. The cultivation of seaweed is therefore encouraged by the European Union (EU) and also by the Dutch government.In the Netherlands, seaweed is farmed on small scale in the Southwest Delta, the Wadden Sea and the North Sea. Despite the
S. M. Schrap   +5 more
wiley   +1 more source

E‐cigarette exposure impairs skeletal muscle mitochondrial function in male mice

open access: yesPhysiological Reports, Volume 14, Issue 5, March 2026.
E‐cigarette vapor induces skeletal muscle mitochondrial dysfunction through AHR‐independent pathways. Abstract While conventional tobacco‐cigarette smoking continues to decline, e‐cigarette (E‐cig) use is rising, yet its physiological consequences remain poorly characterized.
Pavel Mazirka   +9 more
wiley   +1 more source

Updated peer review of the pesticide risk assessment of the active substance dichlorprop‐P and variant dichlorprop‐P‐2‐ethylhexyl

open access: yesEFSA Journal, Volume 24, Issue 2, February 2026.
Abstract The conclusions of the EFSA following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State, Ireland and co‐rapporteur Member State, Poland, for the pesticide active substance dichlorprop‐P and the variant dichlorprop‐P‐2‐ethylhexyl and the assessment of applications for maximum
European Food Safety Authority (EFSA)   +49 more
wiley   +1 more source

BODY MASS INDEX AND OUTCOME OF INSITU VAGINAL WALL SLING SURGERY

open access: yesUrology Research and Practice, 2019
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Ahmet METİN   +2 more
doaj   +2 more sources

An Empirical Equation for Tunnel Squeezing Prediction in Weak Rock Masses

open access: yesAdvances in Civil Engineering
Squeezing in tunnels is a major problem in tunnel engineering that involves cost and occupational safety risks as well as changes in tunnel shape. Accurate estimation of squeezing is important in the early stages of tunnel design and in terms of solving ...
Evren Posluk   +3 more
doaj   +1 more source

Eugenol‐Based Thiazole Derivatives Inhibit the MepA Efflux Pump in Staphylcoccus aureus

open access: yesChemistrySelect, Volume 11, Issue 3, 22 January 2026.
ABSTRACT Multidrug resistant (MDR) bacteria are considered critical priority pathogens by the World Health Organization (WHO). Considering the relevance of antibacterial drug development in this scenario, the present research study aimed to evaluate the antibacterial activity of eugenol‐based thiazole derivatives and analyze their potential to inhibit ...
Ray Silva de Almeida   +13 more
wiley   +1 more source

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