Results 51 to 60 of about 7,461 (172)

The growth and infectivity of Leishmania major is not altered by in vitro exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

BMC Research Notes, 2018
Objective The numbers of Leishmania major parasites in foot lesions of C57Bl/6, BALB/c or SCID mice can be significantly reduced by pre-exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). One potential mechanism to explain this enhanced resistance to
Vera Sazhnev, Gregory K. DeKrey
doaj   +1 more source

A Multicriteria Evaluation of Railway Route Alternatives in Türkiye: An ANP‐Based Multidimensional Sustainability Approach

Applied Computational Intelligence and Soft Computing, Volume 2026, Issue 1, 2026.
Despite Türkiye’s 2053 net‐zero emissions target and national transportation master plan goals to reduce regional inequalities, the simultaneous integration of environmental, financial, operational, and socioeconomic criteria within a single decision framework for inter‐regional railway corridor selection remains underdeveloped.
Deniz Ceren Duygun, Egemen Can, Mert Bıçakcıoğlu, İlke Ölçücü, Yankı Yiğit Uçar, Kerem Şurğun, Ahmet Yücekaya, Özgür Orhangazi, Gökhan Kirkil, Volkan Ediger, Zhaocai Wang   +10 more
wiley   +1 more source

Potential AhR-independent mechanisms of 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibition of human glioblastoma A172 cells migration

Ecotoxicology and Environmental Safety
The toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is generally believed to be mediated by aryl hydrocarbon receptor (AhR), but some evidence suggests that the effects of TCDD can also be produced through AhR-independent mechanisms.
Yiyun Liu, Ruihong Zhu, Tuan Xu, Yangsheng Chen, Yuan Ding, Sijia Zuo, Li Xu, Heidi Qunhui Xie, Bin Zhao   +8 more
doaj   +1 more source

Altered Sex Ratio at Birth with Maternal Exposure to Dioxins in Vietnamese Infants

Toxics
Excess female births (lower sex ratio at birth) associated with paternal exposure to 2,3,7,8-tetrachlordibenzo-p-dioxin (TCDD) have been reported in Italy. However, no significant effects of maternal TCDD exposure on the sex ratio were reported.
Noriko Kaneko, Muneko Nishijo, Hoa Thi Vu, Tai Pham-The, Thao Ngoc Pham, Nghi Ngoc Tran, Tomoya Takiguchi, Yoshikazu Nishino   +7 more
doaj   +1 more source

RETRACTED: 2, 3, 7, 8-Tetrachlorodibenzo-P-dioxin (TCDD) induces premature senescence in human and rodent neuronal cells via ROS-dependent mechanisms.

PLoS ONE, 2014
The widespread environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a potent toxicant that causes significant neurotoxicity. However, the biological events that participate in this process remain largely elusive. In the present study, we
Chunhua Wan, Jiao Liu, Xiaoke Nie, Jianya Zhao, Songlin Zhou, Zhiqing Duan, Cuiying Tang, Lingwei Liang, Guangfei Xu   +8 more
doaj   +1 more source

Organ-specific effects on glycolysis by the dioxin-activated aryl hydrocarbon receptor.

PLoS ONE, 2020
Activation of the aryl hydrocarbon receptor (AHR) by the environmental toxin dioxin (2,3,7,8-tetrachlorodibenzo-p-dioxin, TCDD) causes diverse toxicities, including thymus atrophy and hepatosteatosis.
Silvia Diani-Moore, Tiago Marques Pedro, Arleen B Rifkind   +2 more
doaj   +1 more source

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the differentiation of embryonic stem cells towards pancreatic lineage and pancreatic beta cell function

Environment International, 2019
Animal and epidemiological studies demonstrated association of persistent exposure of TCDD, an endocrine disrupting chemical, to susceptibility of type 2 diabetes (T2D).
John A. Kubi, Andy C.H. Chen, Sze Wan Fong, Keng Po Lai, Chris K.C. Wong, William S.B. Yeung, Kai Fai Lee, Yin Lau Lee   +7 more
doaj   +1 more source

Derivation and internal validation of the multivariate toxigenic C. difficile diarrhea model and risk score for emergency room and hospitalized patients with diarrhea

Antimicrobial Stewardship & Healthcare Epidemiology
Background: Many factors have been associated with the risk of toxigenic C. difficile diarrhea (TCdD). This study derived and internally validated a multivariate model for estimating the risk of TCdD in patients with diarrhea using readily available ...
Sarah Davies, Jimmy Zhang, Yongjun Yi, Eric R. Burge, Marc Desjardins, Peter C. Austin, Carl van Walraven   +6 more
doaj   +1 more source

Indole-3-Carbinol Enhances Alternative Activation of Macrophages via AHR Pathway and Glucose Transporter Regulation

Immuno
Disruption in macrophage polarization is linked to inflammatory diseases and metabolic disorders. Our study aimed to investigate how AHR activation by I3C and TCDD could impact glucose transporters and macrophage phenotypes and functions in human ...
Delara Omrani, Saeed Mohammadi, Moein Malekzadeh, Mohsen Saeidi, Fakhri Sadat Seyedhosseini, Ahmed Al-Harrasi, Yaghoub Yazdani   +6 more
doaj   +1 more source

Proteomic changes of aryl hydrocarbon receptor (AhR)-silenced porcine granulosa cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

PLoS ONE, 2019
2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a toxic man-made chemical compound contaminating the environment and affecting human/animal health and reproduction. Intracellular TCDD action usually involves the activation of aryl hydrocarbon receptor (AhR)
Karina Orlowska, Sylwia Swigonska, Agnieszka Sadowska, Monika Ruszkowska, Anna Nynca, Tomasz Molcan, Agata Zmijewska, Renata E Ciereszko   +7 more
doaj   +1 more source