Results 151 to 160 of about 184,470 (334)

Cancer systems biology of TCGA SKCM: Efficient detection of genomic drivers in melanoma [PDF]

, 2015
Jian Guan, Rohit Gupta, Fabian V. Filipp
openalex   +1 more source

AGTR1 Inhibits the Progression of Lung Adenocarcinoma

Cancer Management and Research, 2021
Lecai Xiong,1 Yanhong Wei,2 Xiao Zhou,1 Peng Dai,1 Yi Cai,1 Xuefeng Zhou,1 Ming Xu,1 Jinping Zhao,1 Hexiao Tang1 1Department of Thoracic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, People’s Republic of China; 2Department of ...
Xiong L, Wei Y, Zhou X, Dai P, Cai Y, Zhou X, Xu M, Zhao J, Tang H   +8 more
doaj  

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

Identification of Gene Expression Pattern Related to Breast Cancer Survival Using Integrated TCGA Datasets and Genomic Tools [PDF]

, 2015
Zhenzhen Huang, Huilong Duan, Haomin Li
openalex   +1 more source

Suppression of tumor antigen presentation during aneuploid tumor evolution contributes to immune evasion

OncoImmunology, 2019
Anti-tumor immune responses impede tumor formation, and cancers have evolved many mechanisms of immune evasion. Confirming earlier findings, we show that human tumors with high chromosomal instability (CIN+) are significantly less immunogenic, as judged ...
Reshmi Tripathi, Vishnu Modur, Laura Senovilla, Guido Kroemer, Kakajan Komurov   +4 more
doaj   +1 more source

RELA Ablation Contributes to Progression of Hepatocellular Carcinoma with TP53R249S Mutation and is a Potential Therapeutic Target

Advanced Science, EarlyView.
Genome‐wide CRISPR/Cas9 based screening identified RELA as a key tumor suppressor in TP53R249S‐mutant HCC. Its loss promotes tumorigenesis and metastasis via DVL1‐mediated Wnt/β‐catenin activation, while its agonist betulinic acid suppresses tumor progression.
Zhiping Wu, Zhe Wang, Diwei Zheng, Yongfang Zheng, Zhiwu Jiang, Jiang Lv, Yueqin Zhu, Heng Jia, Ziyuan Duan, Tingjie Yuan, Qiting Wu, Youguo Long, Shouheng Lin, Yao Yao, Georgia Carson, Jean P. Thiery, Kwan Man, Peng Li   +17 more
wiley   +1 more source

Large-scale RNA-Seq Transcriptome Analysis of 4043 Cancers and 548 Normal Tissue Controls across 12 TCGA Cancer Types [PDF]

, 2015
Li Peng, Xiu Wu Bian, Di Kang Li, Chuan Xu, Guangming Wang, Qing Xia, Qing Xiong   +6 more
openalex   +1 more source

TREMSUCS-TCGA – an integrated workflow for the identification of biomarkers for treatment success

Journal of Integrative Bioinformatics
Many publicly available databases provide disease related data, that makes it possible to link genomic data to medical and meta-data. The cancer genome atlas (TCGA), for example, compiles tens of thousand of datasets covering a wide array of cancer types.
Balogh Gabor, Jorge Natasha, Dupain Célia, Kamal Maud, Servant Nicolas, Le Tourneau Christophe, Stadler Peter F., Bernhart Stephan H.   +7 more
doaj   +1 more source

The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication

Advanced Science, EarlyView.
Despite its canonical role in inhibiting DNA synthesis, GGH promotes tumor growth as a novel RNA‐binding protein. GGH binds GC‐rich 5′UTRs (e.g., CDC6/CCND1), recruits HuR to form a ternary complex that stabilizes mRNA via circular conformation, fueling DNA replication and the cell cycle. Targeting this axis suppresses NSCLC progression.
Yu Li, Xinrui Li, Yuhui Du, Sijie Chen, Xiaoniu He, Zhangrong Xie, Zhiqing Zhou, Huijie Zhao, Xiaofei Zeng, Guoan Chen   +9 more
wiley   +1 more source

Pan-cancer analysis of TCGA data reveals notable signaling pathways [PDF]

, 2015
Richard E. Neapolitan, Curt M. Horvath, Xia Jiang   +2 more
openalex   +1 more source