Advanced Science, EarlyView.An AI‐assisted SERS system is developed to rapidly and reliably detect early gastric cancer by visualizing gastric mucosal acidity, enhancing endoscopic differentiation, improving guidance for submucosal dissection, and reducing false‐positive diagnoses.
Huihui Yan +18 more
wiley +1 more source
Radiomic Features from Multi-Institutional Glioblastoma MRI Offer Additive Prognostic Value to Clinical and Genomic Markers: Focus on TCGA-GBM Collection [PDF]
, 2017 Gaurav Shukla +5 more
openalex +1 more source
Prognostic value of myometrial invasion and TCGA groups of endometrial carcinoma.
Gynecologic Oncology, 2021 A. Raffone +11 more
semanticscholar +1 more source
CircSMEK1 Suppresses HCC via the hnRNPK‐IGF2‐AKT Axis: A Diagnostic Biomarker and Therapeutic Target
Advanced Science, EarlyView.CircSMEK1 is downregulated in MASH/HCC and predicts poor prognosis. It suppresses tumor progression by promoting hnRNPK ubiquitination and inhibiting the IGF2/PI3K/AKT axis, while its loss activates immunosuppressive cancer‐associated fibroblasts. Serum circSMEK1 serves as a non‐invasive diagnostic biomarker, and its restoration potently inhibits HCC ...
Peilan Guo +15 more
wiley +1 more source
Clinical Value and Prospective Pathway Signaling of MicroRNA-375 in Lung Adenocarcinoma: A Study Based on the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and Bioinformatics Analysis [PDF]
, 2017 Ting‐Qing Gan +8 more
openalex +1 more source
Advanced Science, EarlyView.This study identifies ZDHHC12 as a critical mediator of PA‐induced HCC progression. Mechanistically, PA upregulates ZDHHC12 expression through SMARCA4 activation, leading to HDAC8 palmitoylation at Cys244 which blocks HSC70‐mediated lysosomal degradation of HDAC8, thereby promoting HCC development. These findings provide novel mechanistic insights into
Xin Jin +7 more
wiley +1 more source
Advanced Science, EarlyView.This study investigates the expression and functional role of the deubiquitinase PSMD14 in PC, with a focus on the mechanism by which it promotes lactate accumulation–induced histone lactylation, thereby driving aberrant lipid metabolism. These findings establish that dual targeting of PSMD14 and the glycolysis–lactylation signaling axis may represent ...
Ri‐Shang Lu +10 more
wiley +1 more source
Implications of the TCGA Genomic Characterization of Papillary Thyroid Carcinoma for Thyroid Pathology: Does Follicular Variant Papillary Thyroid Carcinoma Exist? [PDF]
, 2014 Sylvia L. Asa +2 more
openalex
Clinical Value of miR-101-3p and Biological Analysis of its Prospective Targets in Breast Cancer: A Study Based on The Cancer Genome Atlas (TCGA) and Bioinformatics [PDF]
, 2017 Chunyao Li +9 more
openalex +1 more source
Advanced Science, EarlyView.In the present study, it is found that in osteosarcoma, lactate‐activated HCAR1 promotes β‐arrestin 2 translocation from cytoplasm to nucleus. In the nucleus, β‐arrestin 2 recruits PP2A to the activated STAT1/2 dimers, mediating STAT1/2 dephosphorylation and inhibiting the transcription of downstream anti‐oncogenes to promote OS progression.
Zhitao Han +26 more
wiley +1 more source