Results 191 to 200 of about 184,470 (334)

Network analysis based on TCGA reveals hub genes in colon cancer [PDF]

open access: gold, 2017
Fenzan Wu   +3 more
openalex   +1 more source

Serine/Threonine Kinase 33 as a Novel Target of Bufalin in Treatment of Triple‐Negative Breast Cancer

open access: yesAdvanced Science, EarlyView.
This study identified that STK33 may serve as a target of Bufalin, which induces the degradation of STK33 and inhibits the growth of TNBC. Furthermore, STK33 is highly expressed in TNBC and enhances TNBC cell proliferation by phosphorylating and stabilizing CCAR1.
Shilong Jiang   +11 more
wiley   +1 more source

APOL2 Stabilizes Ku80 to Confer NHEJ‐Mediated Radioresistance in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
Radiotherapy resistance in gastric cancer (GC) is often mediated by enhanced DNA repair. APOL2 is found to promote NHEJ by stabilizing Ku80, conferring radioresistance. High APOL2 correlates with poor prognosis. Formononetin disrupts APOL2‐Ku80, restoring radiosensitivity, suggesting a novel therapeutic strategy.
Dan Zu   +23 more
wiley   +1 more source

Quantitative MRI radiomics in the prediction of molecular classifications of breast cancer subtypes in the TCGA/TCIA data set

open access: green, 2016
H. Li   +15 more
openalex   +2 more sources

TWF2 Drives Tumor Progression and Sunitinib Resistance in Renal Cell Carcinoma through Hippo Signaling Suppression

open access: yesAdvanced Science, EarlyView.
Twinfilin actin‐binding protein (TWF2) is upregulated in sunitinib‐resistant renal cell carcinoma (RCC) cells, where it interacts with YAP and protects YAP from degradation. Stabilized YAP translocates into the nucleus and activates transcription of target genes, promoting RCC progression and drug resistance.
Liangmin Fu   +25 more
wiley   +1 more source

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