Results 201 to 210 of about 147,649 (246)

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Harnessing Methyltransferase‐Guided Targeting for Sequence‐Specific Proximity Labeling of DNA

Angewandte Chemie, EarlyView.
A novel methyltransferase‐mediated approach leveraging rationally designed S‐adenosyl‐L‐methionine (SAM) analogues was developed to achieve sequence‐specific DNA labeling but in proximity to the natural transfer site, addressing key limitations of previously established methods, including ligand instability and methylation‐sensitive labeling.
Xiong Chen, Gang Wen, Niels Ooghe, Sergey Abakumov, Taoufik Rohand, Volker Leen, Peter Dedecker, Tanja Weil, Johan Hofkens   +8 more
wiley   +2 more sources

Molecular classification and prognosis study of pancreatic ductal adenocarcinoma through multi-omics integrated clustering analysis. [PDF]

PeerJ
Zhong G, Wang L, Fu P, Xi B, Li H, Cheng Y, Lin J, Chen L.   +7 more
europepmc   +1 more source

Deep Learning‐Assisted Coherent Raman Scattering Microscopy

Advanced Intelligent Discovery, EarlyView.
The analytical capabilities of coherent Raman scattering microscopy are augmented through deep learning integration. This synergistic paradigm improves fundamental performance via denoising, deconvolution, and hyperspectral unmixing. Concurrently, it enhances downstream image analysis including subcellular localization, virtual staining, and clinical ...
Jianlin Liu, Rujia Liu, Xinyan Zhang, Xun Chen, Shuhua Yue   +4 more
wiley   +1 more source

Expression of Bruton's Tyrosine Kinase Reflects Immune Cells Infiltration and Cell Proliferation in Breast Cancer. [PDF]

World J Oncol
AlRammah T, Wu R, Chida K, Kawashima K, Hakamada K, Ishikawa T, Ebos JML, Takabe K.   +7 more
europepmc   +1 more source

Molecular characterization of the A52 murine hepatocellular carcinoma cell line

Animal Models and Experimental Medicine, EarlyView.
Hepatocellular carcinoma (HCC) is a poor outcome cancer with limited therapeutic choices. To advance therapeutic development we genetically characterized the A52 murine HCC cell line. We noted genetic changes that match a subset of human HCC and this offers the opportunity to test novel targeted therapies in syngeneic mice.
Rhys Gillman, Eun Jin Sun, Miriam Wankell, Matt A. Field, Ulf Schmitz, Lionel Hebbard   +5 more
wiley   +1 more source

Encoding functional edges in graphs to model spatially varying relationships in the tumor microenvironment. [PDF]

NPJ Artif Intell
Tsang AP, Krishnan SN, Kulkarni R, Bhadury S, di Magliano MP, Frankel TL, Rao A.   +6 more
europepmc   +1 more source

Germline Predisposition to Oncogenic Alkylating Damage in Colorectal Cancer. [PDF]

Cancer Epidemiol Biomarkers Prev
Gurjao C, Cazaubiel J, Tan C, Reardon B, Hofree M, Ugai T, Meyerhardt JA, Nowak JA, Giovannucci E, Townsend JP, Ogino S, Giannakis M.   +11 more
europepmc   +1 more source

Integrating WGCNA and machine learning algorithm to identify ACSM5 as a prognostic biomarker and therapeutic target for predicting immunotherapy efficacy in non-small cell lung cancer. [PDF]

Transl Cancer Res
Ma X, Du W, Bai M, Dai Z.
europepmc   +1 more source