Results 201 to 210 of about 184,470 (334)

Lenvatinib Plus Paclitaxel as Second‐Line Therapy for Advanced Gastric Cancer Patients: A Dose Escalation Exploratory Study

Advanced Science, EarlyView.
This study determines the maximum tolerated dose of lenvatinib in combination with paclitaxel as second‐line therapy for advanced gastric cancer patients. A dynamic network biomarker panel associated with patient prognosis and response to treatment is established.
Chenfei Zhou, Jinling Jiang, Liting Guo, Wenqi Xi, Junwei Wu, Qu Cai, Jun Ji, Feng Qi, Jun Zhang   +8 more
wiley   +1 more source

A Five-microRNA Signature for Survival Prognosis in Pancreatic Adenocarcinoma based on TCGA Data [PDF]

, 2018
Xiuhui Shi, Xu Li, Hang Zhang, Ruizhi He, Yan Zhao, Min Zhou, Shutao Pan, Chunle Zhao, Yechen Feng, Min Wang, Xingjun Guo, Renyi Qin   +11 more
openalex   +1 more source

RadGLO: an interactive platform for radiomic feature analysis and prognostic modeling in glioma. [PDF]

NPJ Precis Oncol
Kundal K, Rani KD, D V, Kumar N, Kumar R.   +4 more
europepmc   +1 more source

Spatial Transcriptomics Reveals Transcriptomic and Immune Microenvironment Reprogramming during Thyroid Carcinoma Dedifferentiation

Advanced Science, EarlyView.
Spatial transcriptomic analysis of Anaplastic thyroid carcinoma (ATC)‐differentiated thyroid carcinoma (DTC) coexisting tumors reveals that coexisting DTC regions with ATC‐like genomic alterations undergo sequential transcriptomic reprogramming and immune microenvironment remodeling, ultimately evolving into a full ATC pathological phenotype.
Kang Ning, Bu Zou, Yongchao Yu, Taonong Cai, Zhenyu Luo, Yu Guo, Yi Wu, Xiujiao Shen, Hao Li, Mengyuan Fang, Jian Bu, Han Hong, Zan Jiao, Tong Wu, Yulong Wang, Tianrun Liu, Weichao Chen, Wanming Hu, Mingjie Jiang, Ankui Yang   +19 more
wiley   +1 more source

Utility of GDF ‐15 as a diagnostic biomarker in gastric cancer: an investigation combining GEO , TCGA and meta‐analysis [PDF]

, 2018
Jieyu Liu, Xing‐Xuan Dong, Jianan Lu, Yue Zhang, Kai‐fan Liu, Ling‐feng Liu, E Qing‐zhi, Xiaojing Lu, Jieyun Yin, Yueping Shen   +9 more
openalex   +1 more source

Single-cell transcriptomic insights into ccRCC: a stemness gene signature for prognosis and treatment response prediction. [PDF]

Discov Oncol
Chen J, Wu X, Han G, Xu C.
europepmc   +1 more source

TREM2‐Mediated Cholesterol Efflux in Macrophages Inhibits Anti‐Tumor Immunity via Limitation of CD4+ T and NK Cells

Advanced Science, EarlyView.
Impaired anti‐tumor immunity is mediated by TREM2 + macrophages in non‐small cell lung cancer. TREM2 + macrophages prevent anti‐tumor immunity depending on the limitation of CD4 + T and NK cells. TREM2 promotes cholesterol efflux via ABCA1 to limit the production of CX3CL1 in macrophages.
Yunhan Wang, Weina Yu, Xinxin Wang, Qitai Zhao, Qingyang Lei, Aitian Li, Shasha Liu, Tian Wang, Li Yang, Yi Zhang   +9 more
wiley   +1 more source

Peer Review #3 of "OncoLnc: linking TCGA survival data to mRNAs, miRNAs, and lncRNAs (v0.3)"

, 2016
Jordan Anaya
openalex   +2 more sources

Multi-cancer analysis of histopathologic MSI screening based on digital histology image. [PDF]

PLoS One
Lee JO, Kim CY, Lee S, Chung JH.
europepmc   +1 more source

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

Advanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji, Weiying Zhang, Fuyuan Xue, Jiazhen Zeng, Qinghua Zhao, Xiaoming Sun, Jian Sun, Heng Zhou, Quanlin Xu, Guoyuan Ma, Shengnan Sun, Ying Wang, Qian Mu, Yi Liu, Qiang Wan   +14 more
wiley   +1 more source