Results 81 to 90 of about 197,260 (304)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
TCGA Chemotherapy Response Dataset
, 2020 Dataset on chemotherapeutic drug responses in TCGA cancer patients, cross-referenced for a hit in TCIA.at database, consisting of clinical (TCGA), cancer tissue gene-expression (TCGA) and tumor-immunome (TCIA) features.
Dalibor Hrg +2 more
core +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Mining TCGA Data Using Boolean Implications
PLoS ONE, 2014 Boolean implications (if-then rules) provide a conceptually simple, uniform and highly scalable way to find associations between pairs of random variables. In this paper, we propose to use Boolean implications to find relationships between variables of different data types (mutation, copy number alteration, DNA methylation and gene expression) from the
Sinha, Subarna +4 more
openaire +6 more sources
ICGC-TCGA-PanCancer/pcawg_delly_workflow: 2.0.4
, 2019 <p>First release after adopting the new way to build docker image, details <a href="https://github.com/ICGC-TCGA-PanCancer/pcawg_delly_workflow/issues/15">here</a></p ...
lindaxiang +6 more
core +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
On the Reproducibility of TCGA Ovarian Cancer MicroRNA Profiles
PLoS ONE, 2013 Abstract Dysregulated microRNA (miRNA) expression is a well-established feature of human cancer. However, the role of specific miRNAs in determining cancer outcomes remains unclear. Using Level 3 expression data from the Cancer Genome Atlas (TCGA), we identified 61 miRNAs that are associated with overall survival in 469 ovarian cancers ...
Wan, Ying-Wooi +4 more
openaire +6 more sources
MARCKS is a New Prognostic Biomarker in Hepatocellular Carcinoma
International Journal of General Medicine, 2023 Haoran Lu,1,* Rou Zhao,2,* Qianqian Qin,3 Liyong Tang,1 Guodong Ma,1 Baoyu He,2 Jing Liang,2 Li Wei,2 Xutong Wang,2 Qingli Bie,2 Xuning Wang,4 Bin Zhang2,5 1Department of Hepatobiliary Surgery, Affiliated Hospital of Jining Medical University ...
Lu H +11 more
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Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
International Journal of General Medicine, 2021 Su-Jeong Kim,1,* Jae-Ho Lee,2,* Woo-Jae Park,1 Shin Kim3– 5 1Department of Biochemistry, College of Medicine, Gachon University, Yeonsu-gu, Incheon, 21999, Republic of Korea; 2Department of Anatomy, School of Medicine, Keimyung University, Dalseo-
Kim SJ, Lee JH, Park WJ, Kim S
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