Results 71 to 80 of about 197,260 (304)

The developmental gene Chordin is amplified and expressed in human cancers

Molecular & Cellular Oncology, 2023
Chordin (CHRD) is a secreted protein important in early development, yet a role for CHRD in human disease has not been identified. In this study we investigated CHRD in cancer and normal adult tissues using the wealth of genome-wide data available in ...
Eric Sosa, Edward M. De Robertis
doaj   +1 more source

TCGA-RCC

, 2018
<p>Renal cell carcinoma data from TCGA</p ...
BO CAI, BO CAI (8305749)
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Addition of MR imaging features and genetic biomarkers strengthens glioblastoma survival prediction in TCGA patients

, 2015
PURPOSE: The purpose of our study was to assess whether a model combining clinical factors, MR imaging features, and genomics would better predict overall survival of patients with glioblastoma (GBM) than either individual data type.
Gevaert, Olivier, Rubin, D.L., Buetow, Kenneth, Wintermark, M., Hu, Ying, Kirby, Justin, Kirby, J., Flanders, A.E., Zinn, Pascal O, Gevaert, O., Wintermark, Max, Gutman, D., Hammoud, Dima A, Raghavan, Prashant, Nicolasjilwan, Manal, Meerzaman, Daoud, Jain, Rajan, Freymann, John, Gutman, David, Hammoud, D.A., Chen, James, Hwang, S.N., Meerzaman, D., Yan, Chunhua, Scarpace, Lisa, Scarpace, L.M., Raghavan, P., Holder, Chad A, Buetow, K., Flanders, Adam E, Jain, R., Zinn, P.O., Colen, R., Mikkelsen, T., Holder, C.A., Hwang, Scott N, Hu, Y., Chen, J., Mikkelsen, Tom, Rubin, Daniel L, Yan, C., Nicolasjilwan, M., Freymann, J., Colen, Rivka   +43 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Reproducible processing of TCGA regulatory networks

GigaScience
Abstract Background Technological advances in sequencing and computation have allowed deep exploration of the molecular basis of diseases. Biological networks have proven to be a useful framework for interrogating omics data and modeling regulatory gene and protein interactions.
Viola Fanfani, Katherine H Shutta, Panagiotis Mandros, Jonas Fischer, Enakshi Saha, Soel Micheletti, Chen Chen, Marouen Ben Guebila, Camila M Lopes-Ramos, John Quackenbush   +9 more
openaire   +3 more sources

Prognostic Significance of Alternative Splicing Genes in Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma

International Journal of General Medicine, 2021
Xiaoyu Wang,* Weichun Tang,* Yilin Lu, Jun You, Yun Han, Yanli Zheng Department of Obstetrics and Gynecology, Nantong First People’s Hospital, Nantong, Jiangsu, 226001, People’s Republic of China*These authors contributed equally to this ...
Wang X, Tang W, Lu Y, You J, Han Y, Zheng Y   +5 more
doaj  

TCGA

The feature matrix and PSN matrix for TCGA dataset.For paper "DeepMoIC: Multi-Omics Data Integration via Deep Graph Convolutional Networks for Cancer Subtype Classification".
Jiecheng Wu (17899004)
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

TREMSUCS-TCGA – an integrated workflow for the identification of biomarkers for treatment success

Journal of Integrative Bioinformatics
Many publicly available databases provide disease related data, that makes it possible to link genomic data to medical and meta-data. The cancer genome atlas (TCGA), for example, compiles tens of thousand of datasets covering a wide array of cancer types.
Balogh Gabor, Jorge Natasha, Dupain Célia, Kamal Maud, Servant Nicolas, Le Tourneau Christophe, Stadler Peter F., Bernhart Stephan H.   +7 more
doaj   +1 more source