Results 111 to 120 of about 6,692 (213)

Acute effects of THC and a CBD+THC combination on cardiovascular haemodynamics and respiratory muscle activity during loaded breathing in healthy adults: A randomized placebo‐controlled crossover study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to evaluate the acute effects of cannabidiol plus tetrahydrocannabinol (CBD+THC) and tetrahydrocannabinol (THC) oils on cardiovascular haemodynamics, respiratory muscle activity and peripheral tissue perfusion in healthy adults. Methods In this randomized, double‐blind, crossover trial, participants received orally administered ...
Edna Karla Ferreira Laurentino   +9 more
wiley   +1 more source

All Quiet on the Luxury Front: How and When Sustainability Labels Influence Purchase Behavior

open access: yesJournal of Consumer Behaviour, EarlyView.
ABSTRACT As luxury brands launch sustainability initiatives and products, they face significant challenges, including the need to effectively communicate their practices to consumers. The current research draws on semiotics theory to explore how and when distinct types of sustainability labels, indexical and iconic, enhance brand authenticity ...
Shelly Rathee   +2 more
wiley   +1 more source

A Stable Isopterin Mimic of a Potent Bacterial Stimulant of T Cells

open access: yesChemistry – A European Journal, EarlyView.
A microbial metabolite covalently binds immunological protein MR1 to potently activate specific lymphocytes called MAIT cells, but it is too unstable for biological applications. Here, using synthesis, assays, protein crystallography, and computer modelling, we report a water‐stable analogue that activates reporter cells expressing the MAIT T cell ...
Jeffrey Y. W. Mak   +9 more
wiley   +1 more source

High‐Dimensional Spectral Flow Cytometry Panel for Immunophenotypic Characterization of Fixed Whole Blood Samples

open access: yesCytometry Part A, EarlyView.
ABSTRACT Peripheral blood mononuclear cells (PBMCs) are commonly used for immune profiling in clinical research, but their isolation and cryopreservation present logistical challenges, particularly in settings with limited access to research facilities. To address this, we implemented a whole blood fixation protocol to preserve surface protein epitopes
Vaishnavi Parthasarathy   +8 more
wiley   +1 more source

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

open access: yesCytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

Extended routine lymphocyte immunophenotyping refines individual immune organization across a heterogeneous patient cohort

open access: yesCytometry Part B: Clinical Cytometry, EarlyView.
Abstract Routine TBNK immunophenotyping detects the major lymphocyte compartments but may underestimate the biologically relevant variation contributed by less frequent but well‐defined minor lymphocyte subsets. This study evaluated whether extending routine TBNK immunophenotyping with minor lymphocyte subsets provides complementary, analytically ...
Carlos Agustin Villegas Valverde   +5 more
wiley   +1 more source

Beyond Thermal Comfort: A Comprehensive Review of Multifunctional Personal Thermal Management Wearables

open access: yesFlexTech, EarlyView.
Regulation strategies, material platforms, and application scenarios of personal thermal management wearables. ABSTRACT Personal thermal management (PTM) has emerged as a vital frontier for protecting individual health, mitigating societal energy burdens, and combating global climate change.
Zhihan Zhang, Haiwen Luan
wiley   +1 more source

Multi‐synergistic strategy for dual‐sensing conductive hydrogels capable of simultaneous strain and temperature monitoring

open access: yesFlexMat, EarlyView.
In this study, a multicomponent synergistic strategy is utilized, which capitalizes on the “intersection” of multiple functional influencing factors to achieve the successful development of a multifunctional hydrogel. Through the construction of a unique three‐dimensional dynamic cross‐linked network, the material combines mechanical strength ...
Wei Li   +10 more
wiley   +1 more source

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