Results 261 to 270 of about 330,850 (283)

The hidden (and lazy) TCR

Blood, 2009
In this issue of Blood, Burns and colleagues analyzed samples from 18 patients with melanoma, treated with T lymphocytes gene-modified to express a tumor-specific TCR. Results show persistence of transduced cells, but early shutdown of TCR gene expression.
BONINI , MARIA CHIARA, Russo V.
openaire   +3 more sources

High-throughput identification of antigen-specific TCRs by TCR gene capture

Nature Medicine, 2013
The transfer of T cell receptor (TCR) genes into patient T cells is a promising approach for the treatment of both viral infections and cancer. Although efficient methods exist to identify antibodies for the treatment of these diseases, comparable strategies to identify TCRs have been lacking.
Linnemann, C., Heemskerk, B., Kvistborg, P., Kluin, R.J.C., Bolotin, D.A., Chen, X.J., Bresser, K., Nieuwland, M., Schotte, R., Michels, S., Gomez-Eerland, R., Jahn, L., Hombrink, P., Legrand, N., Shu, C.J., Mamedov, I.Z., Velds, A., Blank, C.U., Haanen, J.B.A.G., Turchaninova, M.A., Kerkhoven, R.M., Spits, H., Hadrup, S.R., Heemskerk, M.H.M., Blankenstein, T., Chudakov, D.M., Bendle, G.M., Schumacher, T.N.M.   +27 more
openaire   +3 more sources

Functions of TCR and pre-TCR subunits: lessons from gene ablation

Current Opinion in Immunology, 1996
Recent gene-targeting experiments have highlighted the existence of checkpoints that ensure that alpha beta T cells do not complete intrathymic differentiation if they have not attained certain landmark events. These 'proofreading' mechanisms operate by way of the pre-TCR and TCR complexes, which are sequentially expressed during T-cell development ...
B, Malissen, M, Malissen
openaire   +2 more sources

TCR or Not TCR?

Journal of Oral and Maxillofacial Surgery, 2011
Amr, Abdulazim, Nora, Prochnow, Tara, Taeihagh   +2 more
openaire   +2 more sources

Competitive displacement of pT alpha by TCR-alpha during TCR assembly prevents surface coexpression of pre-TCR and alpha beta TCR.

Journal of immunology (Baltimore, Md. : 1950), 2000
During alphabeta T cell development, CD4(-)CD8(-) thymocytes first express pre-TCR (pTalpha/TCR-beta) before their differentiation to the CD4(+)CD8(+) stage. Positive selection of self-tolerant T cells is then determined by the alphabeta TCR expressed on CD4(+)CD8(+) thymocytes. Conceivably, an overlap in surface expression of these two receptors would
S, Trop, M, Rhodes, D L, Wiest, P, Hugo, J C, Zúñiga-Pflücker   +4 more
openaire   +1 more source

TCR

2011
  +4 more sources

TCR

2008
  +4 more sources

TCR

2006
openaire   +2 more sources

Germline TCR contributions

Nature Immunology, 2016
openaire   +2 more sources

Pre-TCR or TCR: developmental implications

Immunology Today, 1997
openaire   +1 more source