Results 231 to 240 of about 272,710 (333)

Distinct landscapes of T-cell immunity and TCR repertoire between sepsis and pre-septic high-risk states. [PDF]

Front Immunol
Ma Y, Shen S, Zheng W, Liu M, Yang X, Wang Y, Zhang X.   +6 more
europepmc   +1 more source

Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen, Jingtian Yu, Wuqiang Wen, Baishan Jiang   +3 more
wiley   +1 more source

TCR repertoire of human cytotoxic CD4 T cells responding to betaherpesviruses HHV-6B and HCMV. [PDF]

Front Immunol
Becerra-Artiles A, Weaver GC, Oluoch PO, Stern LJ.   +3 more
europepmc   +1 more source

Radiotherapy-activated NBTXR3 nanoparticles modulate cancer cell immunogenicity and TCR repertoire. [PDF]

Cancer Cell Int, 2022
Darmon A, Zhang P, Marill J, Mohamed Anesary N, Da Silva J, Paris S.   +5 more
europepmc   +1 more source

Single‐cell multi‐omics analysis of the tumour microenvironment for colorectal cancer liver metastasis

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
Jiao Guan, Mingwei Guo, Min Hu, Shilin Wu, Jin Qiu, Xinran Ma, Yingying Guo, Haibing Chen, Zunqiang Zhou   +8 more
wiley   +1 more source

Multifacet Roles of Cellular Senescence in Cancer: Mechanisms and Therapeutic Implications

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Cellular senescence shapes tumor progression through both antitumor and protumor mechanisms. Senescence triggered by telomere shortening restricts malignant transformation and limits tumor cell proliferation, while the senescence‐associated secretory phenotype (SASP) secretion enhances antitumor immunity by activating cytotoxic T cells.
Huajie Mao, Wanning Liu, Yuanyuan Su, Yuxuan Ma, Xiaodi Zhao, Yuanyuan Lu   +5 more
wiley   +1 more source

SARS-CoV-2 epitope-specific T cells: Immunity response feature, TCR repertoire characteristics and cross-reactivity. [PDF]

Front Immunol, 2023
Yang G, Wang J, Sun P, Qin J, Yang X, Chen D, Zhang Y, Zhong N, Wang Z.   +8 more
europepmc   +1 more source

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

A comprehensive evaluation of diversity measures for TCR repertoire profiling. [PDF]

BMC Biol
Mika J, Polanska A, Blenman KR, Pusztai L, Polanska J, Candéias S, Marczyk M.   +6 more
europepmc   +1 more source

Comprehensive analysis of TCR repertoire of COVID-19 patients in different infected stage. [PDF]

Genes Genomics, 2022
Wang G, Wang Y, Jiang S, Fan W, Mo C, Gong W, Chen H, He D, Huang J, Ou M, Hou X.   +10 more
europepmc   +1 more source