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Individuality of Ag-Selected and Preimmune TCR Repertoires
Immunologic Research, 2001We have combined flow cytometry and single-cell PCR to characterize the TCRBV repertoires selected by individual mice in a model CD8 response against a defined peptide/MHC complex (CW3 170-1 79/Kd). Ourresults established thatdifferent mice select individually distinct yet structurally similar CW3-specific repertoires.
Maryanski, J. L. +6 more
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TCR-beta repertoire development in the mouse embryo
The Journal of Immunology, 1997Abstract We studied the TCR beta-chain repertoire in thymocytes along embryonic development. At day 14 of gestation, complete V-D-J rearrangements of the TCR-beta locus were detected at the messenger RNA level, and a total of 56 different rearrangements were observed in one thymus.
H, Ema, A, Cumano, P, Kourilsky
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TCR repertoire in early fetal mouse thymus
International Immunology, 1995We investigated the rearrangement and expression of TCR genes in mouse fetal thymus organ culture, a system that avoids subsequent entry of hematopoietic precursor cells. The first observable rearranged TCR gene was homogeneous V gamma 2-J gamma 2, detectable as early as fetal day 11 (d11) in the thymic primordia.
H, Ohki-Hamazaki +5 more
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Characterizing the TCR repertoire in Neuropsychiatric Lupus
The Journal of Immunology, 2020Abstract Approximately 40% of lupus patients experience neurological and/or psychiatric disorders. However, the mechanisms contributing to the wide range of neuropsychiatric manifestations (NPSLE) have not yet been fully elucidated.
Erica Moore +2 more
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Chronic Modulation of the TCR Repertoire in the Lymphoid Periphery
The Journal of Immunology, 1999Abstract Using TCR Vβ5 transgenic mice as a model system, we demonstrate that the induction of peripheral tolerance can mold the TCR repertoire throughout adult life. In these mice, three distinct populations of peripheral T cells are affected by chronic selective events in the lymphoid periphery.
C A, Blish +5 more
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T cell diversity and TcR repertoires in teleost fish
Fish & Shellfish Immunology, 2011In vertebrates, the diverse and extended range of antigenic motifs is matched to large populations of lymphocytes. The concept of immune repertoire was proposed to describe this diversity of lymphocyte receptors--IG and TR--required for the recognition specificity.
Castro Sequeiro, Dona Maria Rosario +5 more
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In Vivo Effects of a Bacterial Superantigen on Macaque TCR Repertoires
The Journal of Immunology, 1998Abstract A macaque model was employed to explore staphylococcal enterotoxin B (SEB) superantigen-driven T lymphocyte responses. The SEB-reactive Vβ+ cell subpopulations demonstrated a striking tri-phase response in rhesus monkeys following an SEB challenge in vivo.
Z C, Kou +7 more
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SummaryThe infiltration of human tumors by T cells is a common phenomenon, and over the past decades, it has become increasingly clear that the nature of such intratumoral T‐cell populations can predict disease course. Furthermore, intratumoral T cells have been utilized therapeutically in clinical studies of adoptive T‐cell therapy. In this review, we
Carsten, Linnemann +2 more
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Spectratype/Immunoscope Analysis of the Expressed
AbstractMeasuring the diversity of TCRs utilized by specific primary and memory T cell responses is critical to the fundamental understanding of regulation of the immune system. This unit describes the Spectratype/Immunoscope technique which permits an in depth analysis of the TCR repertoire present in a variety of biological samples from mice to ...
Jeffrey R, Currier, Mary Ann, Robinson
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