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T cell diversity and TcR repertoires in teleost fish
Fish & Shellfish Immunology, 2011In vertebrates, the diverse and extended range of antigenic motifs is matched to large populations of lymphocytes. The concept of immune repertoire was proposed to describe this diversity of lymphocyte receptors--IG and TR--required for the recognition specificity.
Castro Sequeiro, Dona Maria Rosario +5 more
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T Cell Receptor (TCR) Repertoire in Alloimmune Responses
International Reviews of Immunology, 1996A large number of alloantigenic determinants could be generated by both the direct and indirect alloantigen presentation pathways. Hence, a heterogeneous population of T cells expressing a wide variety of receptors would be expected to respond to this diverse array of alloantigenic determinants.
O J Finn, Lisa A Debruyne, D K Bishop
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In Vivo Effects of a Bacterial Superantigen on Macaque TCR Repertoires
The Journal of Immunology, 1998Abstract A macaque model was employed to explore staphylococcal enterotoxin B (SEB) superantigen-driven T lymphocyte responses. The SEB-reactive Vβ+ cell subpopulations demonstrated a striking tri-phase response in rhesus monkeys following an SEB challenge in vivo.
Z C, Kou +7 more
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SummaryThe infiltration of human tumors by T cells is a common phenomenon, and over the past decades, it has become increasingly clear that the nature of such intratumoral T‐cell populations can predict disease course. Furthermore, intratumoral T cells have been utilized therapeutically in clinical studies of adoptive T‐cell therapy. In this review, we
Carsten, Linnemann +2 more
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Spectratype/Immunoscope Analysis of the Expressed
AbstractMeasuring the diversity of TCRs utilized by specific primary and memory T cell responses is critical to the fundamental understanding of regulation of the immune system. This unit describes the Spectratype/Immunoscope technique which permits an in depth analysis of the TCR repertoire present in a variety of biological samples from mice to ...
Jeffrey R, Currier, Mary Ann, Robinson
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The TCR-? chain repertoire of gut-derived T lymphocytes
Seminars in Immunology, 1995The gastrointestinal tract represents a natural barrier to environmental pathogens. The gut-associated lymphoid tissue (GALT) provides protection and interacts with the external environment, e.g. bacteria and food antigens. Large numbers of leukocytes are present as aggregates in the lymphoid follicles and as single cells in the lamina propria and ...
Armelle Regnault +2 more
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Re-shaping the T cell repertoire: TCR editing and TCR revision for good and for bad
Clinical Immunology, 2007Protection against the universe of pathogens requires a functional, diverse T cell repertoire. However, the price that is paid for an evolved, effective immune system includes the potential danger of generating autoaggressive T cells. Autoimmune diseases result from inherent breach of tolerance to self-antigens leading to disruption of the regulatory ...
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Clinical and prognostic implications of the TCR repertoire in leiomyosarcoma.
Journal of Clinical Oncology11573 Background: Leiomyosarcomas (LMS) are aggressive mesenchymal tumors sometimes classified by primary location as uterine LMS (uLMS) versus extra-uterine LMS (eLMS). In pursuit of novel therapies, study of the tumor microenvironment and the repertoire of T-Cell Receptor (TCR) sequences from
John Seng Wang +17 more
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Restricted TCR repertoire and disease
Immunology Today, 1993Oscar G Segurado, Dolores J Schendel
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