Results 131 to 140 of about 95,928 (301)

Disease‐Stage Synchronized Nanozyme Therapy for Polymicrobial Sepsis through Adaptive Catalytic and Immune Reprogramming

Advanced Science, EarlyView.
A disease‐stage synchronized nanozyme platform is developed to treat polymicrobial sepsis by adapting its functions to changing infection environments. The system eliminates multidrug‐resistant bacteria during early infection while reducing inflammation and restoring immune balance during recovery, providing an integrated strategy for infection control
Anlai Zou, Xiaoxue Zhu, Runhan Zhu, Chengchu Xue, Qinyu Zhang, Mengke Li, Ting Yu, Yuzhen Gao, Zhi Ruan, Ying Fu, Yunlei Xianyu, Jun Zhang   +11 more
wiley   +1 more source

Case Report: Immunophenotypically diverse immature patterns, including variable TdT expression, in aggressive B-cell lymphomas and leukemia with MYC rearrangement

Frontiers in Oncology
This study is a retrospective analysis of our case series and literature review of aggressive B-cell lymphomas with MYC rearrangements that show immunophenotypic immaturity, including expression of terminal deoxynucleotidyl transferase (TdT), weak or ...
Daishi Kato, Daishi Kato, Takahiro Fujino, Reiko Isa, Haruya Okamoto, Taku Tsukamoto, Shinsuke Mizutani, Yuji Shimura, Tsutomu Kobayashi, Hitoji Uchiyama, Masafumi Taniwaki, Aya Miyagawa-Hayashino, Junya Kuroda   +12 more
doaj   +1 more source

Tdt e hipermutación

, 2017
Se describe la genética de los anticuerpos y del receptor de la célula T y como se reordenan y mutan somáticamente para generar la diversidad del repertorio inmunológicohttps://polimedia.upv.es/visor/?id=2a56eab0-3fb1-11e7-9b33-83cdd974e088Sirera Pérez,
Sirera Pérez, Rafael
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Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

Advanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang, Xiaowei Cai, Xiaoyan Zhong, Tian Qiu, Qinwei Lu, Jiahao Qin, Fei Gong, Yecheng Huang, Chenyu Jiang, Youdong Chen, Yuan Cheng, Liang Cheng   +11 more
wiley   +1 more source

Nonclinical evaluation of renizgamglogene autogedtemcel for SCD and TDT

Molecular Therapy
Sickle cell disease and transfusion-dependent β-thalassemia can be treated by fetal hemoglobin upregulation. Disruption of the distal BCL11A binding site at the HBG1/2 promoters to induce fetal hemoglobin using either SpCas9 or AsCas12a mimics multiple hereditary persistence of fetal hemoglobin mutations.
Eugenio Marco, Patricia Sousa, Tusneem Janoudi, Edouard de Dreuzy, Jack M. Heath, Ramya Viswanathan, John A. Zuris, Gregory M. Gotta, Georgia Giannoukos, Scott Hansen, David K. Wood, Mark C. Walters, John F. Tisdale, Christopher J. Wilson, Kai-Hsin Chang   +14 more
openaire   +3 more sources

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Monitoring of T-cell acute lymphoblastic leukemia by flow cytometry

Open Medicine, 2010
Janeliūnienė Miglė, Matuzevičienė Rėda, Griškevičius Laimonas, Kučinskienė Zita   +3 more
doaj   +1 more source

Medición de Parámetros de Calidad de las Señales de Televisión Digital Terrestre (TDT) en Sitios Identificados como Zonas de Sombra Dentro del Distrito Metropolitano de Quito

Revista Politécnica, 2015
Resumen: Luego de las pruebas de TDT realizadas en el 2009, se evidencio que existian lugares dentro de la ciudad de Quito con características de zonas de sombra donde la recepción de TDT se tornaba dificil.
Xavier Santiago Páez Vásquez
doaj  

Proteomic Evidence of Complement and Coagulation Pathway Dysregulation in Transfusion-Dependent Thalassemia

Advances in Hematology
Transfusion-dependent thalassemia (TDT) is characterized by chronic hemolysis, ineffective erythropoiesis, and iron overload, resulting in persistent oxidative stress and systemic inflammation.
Afshan Sumera, Ammu K. Radhakrishnan, Abdul Aziz Baba, Soon Keng Cheong   +3 more
doaj   +1 more source

Simulación de Cobertura de Televisión Digital Terrestre (TDT)

, 2020
En este objeto de aprendizaje se enseña cómo simular la cobertura de un transmisor de Televisión Digital Terrestre (TDT) utilizando la herramienta de planificación profesional Xirio Onlinehttps://polimedia.upv.es/visor/?id=6a1a3e30-a521-11ea-a55e ...
Gomez-Barquero, David
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