Results 121 to 130 of about 1,915,493 (292)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Spillovers in product and process innovation: evidence from manufacturing firms. [PDF]

This paper proposes a new empirical approach to assess the impact of knowledge spillovers on firms' productivity and demand. I consider a model where process innovations spillovers to other firms raise firms relative efficiency and technological ...
Ornaghi, Carmine
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

A generalisability theory approach to quantifying changes in psychopathology among ultra-high-risk individuals for psychosis

Schizophrenia
Distinguishing stable and fluctuating psychopathological features in young individuals at Ultra High Risk (UHR) for psychosis is challenging, but critical for building robust, accurate, early clinical detection and prevention capabilities.
Zohreh Doborjeh, Oleg N. Medvedev, Maryam Doborjeh, Balkaran Singh, Alexander Sumich, Sugam Budhraja, Wilson Wen Bin Goh, Jimmy Lee, Margaret Williams, Edmund M-K Lai, Nikola Kasabov   +10 more
doaj   +1 more source

Enhancing Early STEM Engagement: The Impact of Inquiry-Based Robotics Projects on First-Grade Students’ Problem-Solving Self-Efficacy and Collaborative Attitudes

Education Sciences
This study examines the effects of integrating an inquiry-based final project into an early childhood robotics program, focusing on its influence on children’s problem-solving self-efficacy, attitudes toward collaboration, confidence in applying robotics
Rina Zviel-Girshin, Nathan Rosenberg
doaj   +1 more source

Accounting for Research and Productivity Growth Across Industries [PDF]

What factors underlie industry differences in research intensity and productivity growth? We develop a multi-sector endogenous growth model allowing for industry specific parameters in the production functions for output and knowledge, and in consumer ...
L. Rachel Ngai, Roberto M. Samaniego
core  

2010 State New Economy Index [PDF]

, 2010
Measures states' economic structures on twenty-six indicators of their competitiveness in the New Economy: the prominence of knowledge jobs, globalization, economic dynamism, transformation to a digital economy, and technological innovation ...

core  

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

TECHNOLOGICAL INNOVATION ACTIVITIES IN FIRMS AND PROPENSITY OF INDIVIDUALS STARTING NEW BUSINESSES [PDF]

Prior studies have found that knowledge gained from work experience is a way to gather insights for business opportunity recognition. However, little is known about the specific types of knowledge that lead to business founding.
Foo, Maw Der, Lee, Lena, Wong, Poh Kam
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source