Results 51 to 60 of about 7,354,647 (255)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Factors Influencing Consumer Decisions, Taking into Account Modern Trends and Challenges [PDF]

open access: yesProblemi Ekonomiki
The article is aimed at determining the modern factors influencing the choice of consumers, consumer decisions, taking into account both the developed approaches and the latest trends and challenges; systematization of factors.
Nikiforov Andrii A., Portna Oksana V.
doaj   +1 more source

New technologies in general aviation [PDF]

open access: yes, 2010
This research explored the technological needs of GA pilots at international levels. Overall, single pilot operators tend to value costs as the most important feature of any technology, followed by technology that helps with pre-flight tasks as well as
Diaz Vilela, Luis   +2 more
core  

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

open access: yesFEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Who adopts microheating technologies? [PDF]

open access: yes, 2009
Despite the increasing emphasis on the importance of microgeneration heat, such as solar thermal and biomass stoves, adoption by UK householders has been very slow.
Caird, Sally, Roy, Robin
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

open access: yesFEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang   +9 more
wiley   +1 more source

Evaluation of Extension Agents Commitment to the Agricultural Loans and Inputs Supply Programme on Special Rice Production in Delta State, Nigeria

open access: yesJournal of Applied Sciences and Environmental Management, 2014
The study evaluated the activities of Extension agents on Agricultural Loans and Inputs Supply Programme participant farmers’ rice output/income. Data were collected with the aid of questionnaire from 60 Extension agents (participating in the ALIS ...
G F Okwuokenye, D U Okoedo-Okojie
doaj   +1 more source

An Historical Survey on Light Technologies [PDF]

open access: yes, 2018
Following the celebration of the International Year of Light and Light-based Technologies in 2015, this paper presents a survey of the exploitation of light throughout our history. Human beings started using light far into the Stone Age, in order to meet
Guarnieri, Massimo
core   +1 more source

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