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Tecovirimat: First Global Approval
Drugs, 2018Tecovirimat (TPOXX®) is an orthopoxvirus-specific antiviral drug developed by SIGA Technologies in conjunction with the US Department of Health and Human Services' Biomedical Advances Research and Development Authority. It acts by inhibiting the activity of the orthopoxvirus VP37 envelope wrapping protein, thereby preventing the formation of egress ...
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Tecovirimat hepatotoxicity in a man with Mpox infection
Enfermedades infecciosas y microbiologia clinica (English ed.)In the context of the global Mpox outbreak from 2022 to 2024, tecovirimat has been widely used for Mpox treatment, initially demonstrating good tolerance and low toxicity. However, recent studies suggest limited efficacy in reducing Mpox lesions.We present the first reported case of significant hepatocellular injury associated with tecovirimat in a ...
Diana, Ruiz-Cabrera +12 more
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