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Potential role of tedizolid phosphate in the treatment of acute bacterial skin infections
Tedizolid phosphate (TR-701), a prodrug of tedizolid (TR-700), is a next-generation oxazolidinone that has shown favorable results in the treatment of acute bacterial skin and skin-structure infections in its first Phase III clinical trial. Tedizolid has
Grau, Santiago +6 more
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To evaluate safety and efficacy of tedizolid phosphate in the management of several skin infections
Tedizolid Phosphate is an oxazolidinone-class antibiotic and is used for the treatment of acute bacterial skin and skin structure infections. it is a prodrug activated by plasma or intestinal phosphatases to tedizolid following administration of the drug
Mohammed, Abdul Aala +3 more
core
Tedizolid: A Novel Oxazolidinone for Gram-Positive Infections [PDF]
Clinical Infectious Diseases, 2014 openaire +2 more sources
Nocardiosis pulmonar tratada con tedizolid
FARMACIA HOSPITALARIA, 2019 Giménez Arufe, Víctor +4 more
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Tedizolid (TR-701): a new oxazolidinone with enhanced potency
Expert Opinion on Investigational Drugs, 2012Tedizolid phosphate (TR-701) is a new oxazolidinone prodrug that is transformed in the serum into the active drug tedizolid (TR-700). Tedizolid acts by inhibiting protein synthesis and has broad activity against Gram-positive pathogens, including strains that are resistant to linezolid.This review summarizes the currently available data on this new ...
Zeina A Kanafani, G Ralph Corey
exaly +3 more sources
Safety and Tolerability of More than Six Days of Tedizolid Treatment
Antimicrobial Agents and Chemotherapy, 2020 Tedizolid has demonstrated its efficacy and safety in clinical trials; however, data concerning its tolerability in long-term treatments are scarce.
Mireia Mensa Vendrell +2 more
exaly +2 more sources
A closer inspection of tedizolid
The Lancet Infectious Diseases, 2015I read the Article by Gregory Moran and colleagues, who used intention to treat (ITT) analysis of a noninferiority trial, with great interest. ITT is widely accepted as the appropriate analysis for randomised controlled trials. However, this recognition is based on assumptions of trial design. Superiority trials (ie, the attempt to prove treatment A is
openaire +4 more sources
Tedizolid: A new oxazolidinone antimicrobial
American Journal of Health-System Pharmacy, 2014The mechanism of action, pharmacokinetics, pharmacodynamics, and clinical efficacy and safety of an investigational second-generation oxazolidinone are reviewed.Tedizolid is a protein synthesis inhibitor in clinical development for the treatment of gram-positive infections.
Kisgen, Jamie J. +3 more
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Long-term use of tedizolid for pulmonary nocardiosis
Journal of Infection and Chemotherapy, 2022Nocardiosis usually occurs in immunocompromised patients and causes infections in various organs, including the lungs, skin, and organs of the central nervous system. Herein, we report the case of a patient with minimal change nephrotic syndrome who had been on immunosuppressive drugs and developed pulmonary nocardiosis due to Nocardia nova complex and
Yuri Chomei +2 more
openaire +2 more sources
An evaluation of tedizolid for the treatment of MRSA infections
Expert Opinion on Pharmacotherapy, 2018Methicillin-resistant Staphylococcus aureus (MRSA)is a common pathogen in acute bacterial skin and soft tissue infections (ABSSSIs), nosocomial pneumonia, bacteremia, endocarditis, as well as diabetic foot, bone, and joint infections. Areas covered: This review summarizes the randomized controlled trials that evaluated the clinical efficacy of ...
Ronald G, Hall +3 more
openaire +2 more sources