Results 121 to 130 of about 957 (147)
Antibiotics Misuse and Antimicrobial Resistance Development in Agriculture: A Global Challenge. [PDF]
Environ Health (Wash)Singh B, Bhat A, Ravi K.
europepmc +1 more source
Total synthesis of Met10-teixobactin
Tetrahedron Letters, 2019 The total synthesis of cyclic depsipeptide Met10-teixobactin in solution-phase is described. Teixobactin is a structurally and mechanistically novel antimicrobial peptidic natural product with very impressive activities against Gram-positive pathogens. It happens to possess an l-allo-enduracididine (End) residue as part of macrocyclic ring which is not
D Srinivasa Reddy
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Establishing the structure-activity relationship of teixobactin
Chinese Chemical Letters, 2019 Abstract In 2015, a new antimicrobial peptide agent was discovered, termed teixobactin. Over the past few years, the structure-activity relationship of teixobactin has been extensively studied. Here, the updated studies have been summarized to provide structure-activity relationship established to date.
Eilidh J Matheson +2 more
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Chemistry and Biology of Teixobactin
Chemistry – A European Journal, 2017AbstractBacterial resistance to existing drugs is becoming a serious public health issue, urging extensive search for new antibiotics. Teixobactin, a cyclic depsipeptide discovered in a screen of uncultured bacteria, shows potent activity against all the tested Gram‐positive bacteria.
Chuchu Guo +4 more
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Teixobactin: A Resistance-Evading Antibiotic for Treating Anthrax
ACS Infectious DiseasesThe antimicrobial resistance (AMR) crisis has been associated with millions of deaths. Of particular concern is the threat of bioweapons, exemplified by anthrax. Introduction of novel antibiotics helps mitigate AMR, but does not address the threat of bioweapons with engineered resistance.
Losee L Ling +2 more
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Teixobactin – Entdeckung und Wirkungsmechanismus
2015Weltweit nimmt die Ausbreitung pathogener Bakterien mit ausgeprägten Antibiotika-Resistenzen stetig zu; demgegenüber sinkt die Entdeckung und Entwicklung neuer Antibiotika in den vergangenen Jahren kontinuierlich. Um bakterielle Infektionen weiterhin effektiv bekämpfen zu können,[for full text, please go to the a.m. URL]
Schneider, T, Lewis, K
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Solution-phase total synthesis of teixobactin
Organic & Biomolecular Chemistry, 2019The first solution-phase total synthesis of teixobactin was completed with a 5.6% yield over 20 steps.
Bowen Gao +5 more
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Converting Teixobactin into a Cationic Antimicrobial Peptide (AMP)
Journal of Medicinal Chemistry, 2017Teixobactin is a head to side chain cyclodepsipeptide that contains two positive charges. One is found in the cycle, as a result of the presence of the guanidino-unusual amino acid L-allo-End, while the other is at the N-terminal. Here we introduce 26 new Teixobactin analogues with an increasing number of positive charges.
Shimaa A. H. Abdel Monaim +4 more
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Genomewide Profiling of the Enterococcus faecalis Transcriptional Response to Teixobactin Reveals CroRS as an Essential Regulator of Antimicrobial Tolerance [PDF]
MSphere, 2019 Teixobactin is a new antimicrobial of significant interest. It is active against a number of multidrug-resistant pathogens, including Staphylococcus aureus and Enterococcus faecalis, with no reported mechanisms of teixobactin resistance.
Rachel L Darnell +2 more
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