Results 211 to 220 of about 161,718 (344)

Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism

Science, 2017
K. Chiba, Franziska K. Lorbeer, A. Shain, D. McSwiggen, Eva Schruf, Areum Oh, Jekwan Ryu, X. Darzacq, Boris C. Bastian, D. Hockemeyer   +9 more
semanticscholar   +1 more source

Aging Reshapes γ/δ T‐Cell Immunity Through a Type I Interferon–Foxo1 Axis

Aging Cell, Volume 25, Issue 2, February 2026.
Aging reshapes the peripheral γ/δ T‐cell compartment by promoting the expansion and enhanced IL‐17–driven activity of innate‐like γ/δ T cells in secondary lymphoid organs. This remodeling is controlled by type I interferon–dependent downregulation of Foxo1, linking aging to heightened pro‐inflammatory γ/δ T‐cell responses.
Aurélie Durand, Sarah Porte, Eryang Xing, Christian Wu, Agnès Le Bon, Cédric Auffray, Bruno Lucas, Bruno Martin   +7 more
wiley   +1 more source

Global research trends and prospects related to telomerase within breast cancer: a bibliometric and visual analysis. [PDF]

Discov Oncol
Qu L, Ding S, Long Q, Yi W.
europepmc   +1 more source

A novel inhibitor of human telomerase derived from 10H-indolo[3,2-b]quinoline

, 2000
Vittorio Caprio, Berengere Guyen, Yaw Opoku‐Boahen, John Mann, Sharon Gowan, Lloyd M. Kelland, Martin A. Read, Stephen Neidle   +7 more
openalex   +1 more source

Sex Differences in Associations Between Adversity and Biological Ageing

Aging Cell, Volume 25, Issue 2, February 2026.
Childhood adversity was associated with older biological ageing profiles (metabolomic ageing, frailty, telomeres, grip strength) primarily in females, supported by sex‐stratified analyses. Adulthood adversity showed stronger associations in males, particularly for frailty and grip strength, with significant sex‐by‐adversity interactions, highlighting ...
Julian Mutz, Luca Di Benedetto, Thole H. Hoppen, Nexhmedin Morina, Monica Aas   +4 more
wiley   +1 more source

Pancreatic Cancer Stem Cells Co-Expressing SOX2, OCT4, and TERT^high Represent an Aggressive Subpopulation. [PDF]

Cells
Curiel-Gomez E, Romero-Rodriguez DP, Rodriguez-Dorantes M, Maldonado V, Melendez-Zajgla J.   +4 more
europepmc   +1 more source

Telomerase activation cooperates with inactivation of p16 in early head and neck tumorigenesis [PDF]

, 2001
Jean‐Charles Soria, Luc Morat, Frédéric Commo, Dominique Dabit, Sophie Périé, Laure Sabatier, P Fouret   +6 more
openalex   +1 more source

The tandem–random transition of cellular patterning: proposed roles of N‐cadherin‐based orientational cell adhesions in the development, maintenance, and degeneration of the nucleus pulposus

Biological Reviews, Volume 101, Issue 1, Page 268-278, February 2026.
ABSTRACT Intervertebral disc degeneration (IDD) can contribute to lower back and neck pain. In IDD, the most affected component of the intervertebral disc is the nucleus pulposus (NP). Derived from the notochord, where cells are organized into a tandem configuration, young NP cells cluster in three‐dimensional (3D) networks embedded in a gelatinous ...
Xiangyun Wei, Nam Vo, Gwendolyn A. Sowa
wiley   +1 more source

Nuclear actin and DNA replication stress regulate telomere maintenance by telomerase. [PDF]

Nat Commun
Harman A, Kartawinata M, Maroun NM, Nguyen DR, Rahman S, Hughes WE, Winardi K, Cohen SB, Cesare AJ, Lamm N, Bryan TM.   +10 more
europepmc   +1 more source

Tetrahymena Telomerase Protein p65 Induces Conformational Changes throughout Telomerase RNA (TER) and Rescues Telomerase Reverse Transcriptase and TER Assembly Mutants

, 2010
Andrea J. Berman, Anne R. Gooding, Thomas R. Cech   +2 more
openalex   +2 more sources