Results 231 to 240 of about 113,797 (252)
Some of the next articles are maybe not open access.
Rejuvenation Research, 2006
Given the constitutive expression of telomerase in the majority of human tumors, telomerase inhibition is an attractive, broad-spectrum therapeutic target for cancer treatment. Therapeutic strategies for inhibiting telomerase activity have included both targeting components of telomerase (the protein component, TERT, or the RNA component, TERC) or by ...
Aisha, Siddiqa +2 more
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Given the constitutive expression of telomerase in the majority of human tumors, telomerase inhibition is an attractive, broad-spectrum therapeutic target for cancer treatment. Therapeutic strategies for inhibiting telomerase activity have included both targeting components of telomerase (the protein component, TERT, or the RNA component, TERC) or by ...
Aisha, Siddiqa +2 more
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Trends in Biotechnology, 2001
There has been a vast increase in telomerase research over the past several years, with many different pre-clinical approaches being tested for inhibiting the activity of this enzyme as a novel therapeutic modality to treat malignancy. In this review, we will provide some basic background information about telomeres and telomerase and then discuss the ...
L K, White, W E, Wright, J W, Shay
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There has been a vast increase in telomerase research over the past several years, with many different pre-clinical approaches being tested for inhibiting the activity of this enzyme as a novel therapeutic modality to treat malignancy. In this review, we will provide some basic background information about telomeres and telomerase and then discuss the ...
L K, White, W E, Wright, J W, Shay
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Current Opinion in Structural Biology, 2011
Telomeres and their associated proteins are specialized structures at the ends of linear chromosomes that function as caps that protect the DNA from exonuclease degradation and recombination events that could lead to genomic instability. In this review, we discuss recent publications describing the high-resolution structures of individual domains and ...
Mark, Mason +2 more
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Telomeres and their associated proteins are specialized structures at the ends of linear chromosomes that function as caps that protect the DNA from exonuclease degradation and recombination events that could lead to genomic instability. In this review, we discuss recent publications describing the high-resolution structures of individual domains and ...
Mark, Mason +2 more
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Cancer Letters, 2003
The unique biology of telomeres and telomerase plays important roles in many aspects of mammalian cell physiology. Over the past decade, several lines of evidence have confirmed that the maintenance of telomeres and telomerase participate actively in the pathogenesis of human cancer.
Kenkichi, Masutomi, William C, Hahn
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The unique biology of telomeres and telomerase plays important roles in many aspects of mammalian cell physiology. Over the past decade, several lines of evidence have confirmed that the maintenance of telomeres and telomerase participate actively in the pathogenesis of human cancer.
Kenkichi, Masutomi, William C, Hahn
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1995
Abstract In three ciliates and two mammals it has been shown that terminal repeat sequences are synthesized by a specialized DNA polymerase called telomerase (reviewed by Greider 1990; Blackburn 1992). This chapter investigates to what extent the known properties of telomerase are consistent with various features of the terminal repeat ...
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Abstract In three ciliates and two mammals it has been shown that terminal repeat sequences are synthesized by a specialized DNA polymerase called telomerase (reviewed by Greider 1990; Blackburn 1992). This chapter investigates to what extent the known properties of telomerase are consistent with various features of the terminal repeat ...
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Gan to kagaku ryoho. Cancer & chemotherapy, 1996
Telomerase is expected to be a powerful tool for cancer diagnosis and cancer chemotherapeutics because of its selective expression exclusively in various cancer tissues at a high frequency (90%) in human somatic tissues. Some precancerous tissues also express telomerase at a high frequency. Normal somatic tissues are mostly telomerase negative.
T, Ide, H, Tahara
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Telomerase is expected to be a powerful tool for cancer diagnosis and cancer chemotherapeutics because of its selective expression exclusively in various cancer tissues at a high frequency (90%) in human somatic tissues. Some precancerous tissues also express telomerase at a high frequency. Normal somatic tissues are mostly telomerase negative.
T, Ide, H, Tahara
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Current Opinion in Genetics & Development, 1993
The ends of eukaryotic chromosomes are defined by specialized nucleoprotein complexes called telomeres. Telomeres impart stability to the genome and are of general interest due to their unique structure and unconventional mode of synthesis. Recent work has identified new components of the telomere complex and expanded our understanding of the role of ...
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The ends of eukaryotic chromosomes are defined by specialized nucleoprotein complexes called telomeres. Telomeres impart stability to the genome and are of general interest due to their unique structure and unconventional mode of synthesis. Recent work has identified new components of the telomere complex and expanded our understanding of the role of ...
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Rinsho byori. The Japanese journal of clinical pathology, 2003
Telomerase, an intranuclear enzyme, binds to telomeres at chromosome ends, helps to elongate telomere length and is closely linked to attainment of cellular immortality, a step in carcinogenesis. Since telomerase activity has been detected in several human tumors and hematopoietic malignancies, this enzyme is thought to be a useful marker for cancer ...
Naoki, Tsuji, Naoki, Watanabe
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Telomerase, an intranuclear enzyme, binds to telomeres at chromosome ends, helps to elongate telomere length and is closely linked to attainment of cellular immortality, a step in carcinogenesis. Since telomerase activity has been detected in several human tumors and hematopoietic malignancies, this enzyme is thought to be a useful marker for cancer ...
Naoki, Tsuji, Naoki, Watanabe
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2000
The past few years have brought a flood of new information to the telomerase field. The identification of multiple components of both the telomere and telomerase, the understanding of the importance of telomere maintenance to the long term viability of cells, and the demonstration of the utility of telomerase inhibition in limiting tumor cell growth ...
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The past few years have brought a flood of new information to the telomerase field. The identification of multiple components of both the telomere and telomerase, the understanding of the importance of telomere maintenance to the long term viability of cells, and the demonstration of the utility of telomerase inhibition in limiting tumor cell growth ...
openaire +2 more sources