Results 91 to 100 of about 128,505 (270)
Recent Advances in Chemical Probing Strategies for RNA Structure Determination in Vivo
Chemistry – A European Journal, EarlyView.This Review illustrates how structural probes combined with advanced sequencing technologies are revolutionizing our ability to map RNA structures and interactions within living cells. It highlights the development of innovative strategies tailored to probe RNA structures in particular biological contexts.
Maryana Yarshova +2 more
wiley +1 more source
Telomerase reverse transcriptase gene amplification in hematological malignancies
Egyptian Journal of Medical Human Genetics, 2019 Background Telomere is a complex DNA–protein structure located at the end of all eukaryotic chromosomes. The major role of human telomerase is to catalyze the addition of telomeric repeat sequences TTAGGG onto chromosome ends for stabilization of ...
Amany H. Abdelrahman +7 more
doaj +1 more source
The Roles of Telomerase in the Generation of Polyploidy during Neoplastic Cell Growth
Neoplasia: An International Journal for Oncology Research, 2013 Polyploidy contributes to extensive intratumor genomic heterogeneity that characterizes advanced malignancies and is thought to limit the efficiency of current cancer therapies.
Agni Christodoulidou +7 more
doaj +1 more source
The yeast telomerase RNA, TLC1, participates in two distinct modes of TLC1-TLC1 association processes in vivo [PDF]
PeerJ, 2016 Telomerase core enzyme minimally consists of the telomerase reverse transcriptase domain-containing protein (Est2 in budding yeast S. cerevisiae) and telomerase RNA, which contains the template specifying the telomeric repeat sequence synthesized.
Tet Matsuguchi, Elizabeth Blackburn
doaj +2 more sources
Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene
Genes, 2016 Embryonic stem cells and induced pluripotent stem cells have the ability to maintain their telomere length via expression of an enzymatic complex called telomerase.
Muhammad Khairul Ramlee +3 more
semanticscholar +1 more source
Preoperative Detection of Dual TERT Promoter Mutations in Thyroid Cancer: A Case Series
Diagnostic Cytopathology, EarlyView.ABSTRACT Telomerase reverse transcriptase promoter (TERTp) mutations are associated with aggressive thyroid cancer and are most frequently found in anaplastic and poorly differentiated thyroid cancer. Pre‐operative thyroid nodule molecular testing can detect TERTp, denoting a high risk of malignancy and possible aggressive clinical features such as ...
Amir Harari +7 more
wiley +1 more source
Diagnostic Value of Methylated Human Telomerase Reverse Transcriptase in Human Cancers: A Meta-Analysis [PDF]
, 2015 published_or_final_versio
Chan, YW +6 more
core +1 more source
Genes, 2016 The accumulated evidence has pointed to a key role of telomerase in carcinogenesis. As a RNA-dependent DNA polymerase, telomerase synthesizes telomeric DNA at the end of linear chromosomes, and attenuates or prevents telomere erosion associated with cell
Tiantian Liu, Xiaotian Yuan, Dawei Xu
semanticscholar +1 more source
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang +7 more
wiley +1 more source
Telomerase: An exploration toward the end of cancer
Indian Journal of Dental Research, 2017 Background: The distinguishing feature of cancer cells is their ability to proliferate indefinitely, which is in contrast to the restricted cell multiplication potential for somatic cells.
Deepika Bablani Popli +2 more
doaj +1 more source