Results 131 to 140 of about 128,505 (270)

PLK4 is a potential therapeutic target in nonmelanoma skin cancers: Evidence from molecular and in vivo studies

Photochemistry and Photobiology, EarlyView.
Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye, Debra R. Garvey, Gagan Chhabra, Chandra K. Singh, Minakshi Nihal, Nihal Ahmad   +5 more
wiley   +1 more source

Deregulation of the telomerase reverse transcriptase (TERT) gene by chromosomal translocations in B-cell malignancies [PDF]

, 2010
Sequence variants at the TERT-CLPTM1L locus in chromosome 5p have been recently associated with disposition for various cancers. Here we show that this locus including the gene encoding the telomerase reverse-transcriptase TERT at 5p13.33 is rarely but ...
Akasaka, T. (T.), Ammerpohl, O. (Ole), Callet-Bauchu, E. (E.), Dyer, M.J.S. (Martin J. S.), Gascoyne, R.D (R. D.), Gesk, S. (Stefan), Harder, L. (Lana), Horsman, D. (D.), Klapper, W. (Wolfram), Majid, A. (Aneela), Martin-Subero, J.I. (Jose Ignacio), Martinez-Climent, J.A. (José Ángel), Nagel, I. (Inga), Siebert, R. (Reiner), Stilgenbauer, S. (Stepahn), Szczepanowski, M. (Monika), Tönnies, H. (Holger)   +16 more
core  

The proximal promoter region of is sufficient to regulate telomerase activity in ES cells and transgenic animals [PDF]

, 2006
Background The reverse transcriptase of telomerase (Tert) controls telomerase activity maintaining the end of linear chromosomes in eukaryotic cells. Telomerase function is highly active in undifferentiated multipotent stem cells, decreases with cell ...
Eva Pericuesta, Miguel Ramírez, Ana Villa-Diaz, Aroa Relaño-Gines, Juan Maria Torres, Marta Nieto, Belen Pintado, Alfonso Gutiérrez-Adán   +7 more
core   +2 more sources

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

Engineering Immortalized Bovine Granulosa Cells Using a Triple‐Gene Approach: Mutant CDK4, Cyclin D1, and TERT

Cell Biology International, Volume 50, Issue 2, February 2026.
ABSTRACT Advancing reproductive technologies in livestock is essential to improve both productivity and genetic potential of cattle. Despite this importance, application of reproductive biotechnologies in cattle breeding remains limited. Bovine granulosa cells (bGCs), which are key components of the ovarian follicle, are critical in female reproduction
Lanlan Bai, Minami Takahashi, Jin Kobayashi, Takahiro Eitsuka, Himari Matsusaka, Taku Ozaki, Eriko Sugano, Hiroshi Tomita, Yuan Xu, Kazuhiro Kawamura, Kiyotaka Nakagawa, Tohru Kiyono, Tomokazu Fukuda   +12 more
wiley   +1 more source

Recent progress in human telomerase structure and its therapeutic targeting

Frontiers in Molecular Biosciences
Most cancer and stem cells activate telomerase to preserve critical genetic material during cell division. Telomerase is a reverse transcriptase ribonucleoprotein that adds telomeric repeats to chromosome ends, thus overcoming the end-replication problem.
Muaath Ebrahim Almansoori, Abdulrahman Awad, Sarah Dhaiban, Mohammed Turki Alduhoori, Humayun Sharif, Abdulrahim Sajini   +5 more
doaj   +1 more source

Telomere protein complexes and their role in lymphoid malignancies [PDF]

, 2017
Telomeres are highly regulated and dynamic complexes that protect the genomic DNA and prevent the end of linear chromosomes from being misrecognized as a broken DNA.
Dos Santos, Patricia Carolina, Panero, Julieta, Slavutsky, Irma Rosa   +2 more
core  

1179. Cancer-Specific Killing by the Suicide Gene (CD) Using the Human Telomerase Reverse Transcriptase Promoter [PDF]

, 2002

openalex   +1 more source

Genetic variants underlying precancerous conditions of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 488-502, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for 80% of cases worldwide. While chronic hepatitis B and C infections remain primary risk factors, emerging evidence highlights the increasing contributions of metabolic dysfunction‐associated steatotic liver disease (MASLD) and alcohol‐associated liver disease
Jonathan Jaime G. Guerrero, Paolo C. Encarnacion, Mark Angelo S. del Rosario, Matthew Aldren S. Ora, Jiayan Zhou, Kin Israel Notarte, Wan‐Chun Li, Ching‐Wen Chang   +7 more
wiley   +1 more source

Minimized human telomerase maintains telomeres and resolves endogenous roles of H/ACA proteins, TCAB1, and Cajal bodies

eLife, 2016
We dissected the importance of human telomerase biogenesis and trafficking pathways for telomere maintenance. Biological stability of human telomerase RNA (hTR) relies on H/ACA proteins, but other eukaryotes use other RNP assembly pathways.
Jacob M Vogan, Xiaozhu Zhang, Daniel T Youmans, Samuel G Regalado, Joshua Z Johnson, Dirk Hockemeyer, Kathleen Collins   +6 more
doaj   +1 more source