Results 201 to 210 of about 45,103 (233)

Canis familiaris telomerase reverse transcriptase undergoes alternative splicing

Mammalian Genome, 2008
The enzyme telomerase is essential for cell proliferation and tumorigenesis. Telomerase reverse transcriptase (TERT) represents the catalytic subunit of the enzyme. In humans, TERT expression is regulated by several different mechanisms, including alternative splicing.
Katerina, Angelopoulou, Michael, Zavlaris, Nikolaos, Papaioannou, Ioannis, Vlemmas   +3 more
openaire   +2 more sources

Telomerase reverse transcriptase gene amplification in hepatocellular carcinoma

Journal of Gastroenterology and Hepatology (Australia), 2004
AbstractBackground and Aim:  Telomerase activation is essential for the immortality of cancer cells. The expression of telomerase reverse transcriptase (hTERT), the catalytic component of the telomerase complex, regulates telomerase activity in human cancers.
Yoshitaka, Takuma, Kazuhiro, Nouso, Yoshiyuki, Kobayashi, Shinichiro, Nakamura, Hironori, Tanaka, Eiji, Matsumoto, Tatsuya, Fujikawa, Mayumi, Suzuki, Tadashi, Hanafusa, Yasushi, Shiratori   +9 more
exaly   +3 more sources

The Structure and Function of Telomerase Reverse Transcriptase

Annual Review of Biochemistry, 2006
The structure and integrity of telomeres are essential for genome stability. Telomere dysregulation can lead to cell death, cell senescence, or abnormal cell proliferation. The maintenance of telomere repeats in most eukaryotic organisms requires telomerase, which consists of a reverse transcriptase (RT) and an RNA template that dictates the synthesis
Chantal, Autexier, Neal F, Lue
openaire   +2 more sources

Telomerase reverse transcriptase mRNA expression and telomerase activity in hepatocellular carcinoma

Journal of Gastroenterology, 1999
Human telomerase reverse transcriptase (hTERT) has been identified as the catalytic subunit of human telomerase. To clarify the clinical significance of hTERT mRNA in hepatocellular carcinoma (HCC), we investigated the relationship between telomerase activity and hTERT mRNA in human HCC and non-HCC tissues. The hTERT mRNA was detected in 17 (89.47%) of
K, Nagao, M, Tomimatsu, H, Endo, H, Hisatomi, K, Hikiji   +4 more
openaire   +2 more sources

TELOMERASE REVERSE TRANSCRIPTASE IN ATHEROSCLEROSIS

2017
Telomerase reverse transcriptase (TERT) is the catalytic subunit of telomerase and the limiting factor for the enzyme activity. The expression of TERT and telomerase activity is increased in atherosclerotic plaques. However, the role of TERT dysregulation during atherosclerosis formation remains unknown.
openaire   +1 more source

PAX8 Regulates Telomerase Reverse Transcriptase and Telomerase RNA Component in Glioma

Cancer Research, 2008
Abstract Paired box (PAX) developmental genes are frequently expressed in cancers and confer survival advantages on cancer cells. We have previously found that PAX genes are deregulated in glioma. We have now investigated the expression of PAX genes in glioma and their role in telomere maintenance.
Yu-Jen, Chen, Hamish G, Campbell, Anna K, Wiles, Michael R, Eccles, Roger R, Reddel, Antony W, Braithwaite, Janice A, Royds   +6 more
openaire   +2 more sources

Expression of Telomerase Reverse Transcriptase in Adult Goldfish Retina

Journal of Molecular Neuroscience, 2007
Telomerase, a specialized reverse transcriptase that maintains telomere during cell division, is commonly associated with cell proliferation. Increasing evidence suggests that telomerase may bear functions other than telomere elongation. We investigated whether telomerase is expressed in the continuously growing goldfish retina.
Lau, BWM, So, KF, Tsao, GSW, Yip, HK
openaire   +4 more sources

Immunoprecipitation of Human Telomerase Reverse Transcriptase with Telomerase Activity

Analytical Biochemistry, 2001
J M, Kraveka, D, Schady, L M, Obeid, B, Ogretmen   +3 more
openaire   +2 more sources

Cancer immunotherapy targeting the telomerase reverse transcriptase.

Cellular & molecular immunology, 2006
The human telomerase reverse transcriptase (hTERT) is expressed in more than 85% of tumor cells but is usually not found in normal cells, which makes hTERT as an ideal tumor-associate antigen (TAA) to develop potential vaccine specifically destroying cancers without impairing normal tissues in human cancer immunotherapy.
Long Fei, Huo, Janice Ws, Tang, Jun Jian, Huang, Pei Tang, Huang, Cui Fen, Huang, Hsiang Fu, Kung, Marie C, Lin   +6 more
openaire   +1 more source

Non-canonical functions of Telomerase Reverse Transcriptase – Impact on redox homeostasis

Redox Biology, 2020
Joachim Altschmied, Judith Haendeler
exaly