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Template definition by Tetrahymena telomerase reverse transcriptase [PDF]

EMBO Journal, 2000
The ribonucleoprotein enzyme telomerase extends chromosome ends by copying a specific template sequence within its integral RNA component. An active recombinant telomerase RNP is minimally composed of this RNA and the telomerase reverse transcriptase (TERT) protein, which contains sequence motifs conserved among viral reverse transcriptases (RTs ...
Kathleen Collins
exaly   +3 more sources

Molecular cloning and characterization of AtTERT, a telomerase reverse transcriptase homolog in Arabidopsis thaliana

FEBS Letters, 1999
On the basis of its predicted homology to human telomerase reverse transcriptase (hTERT), a cDNA for Arabidopsis thaliana TERT (AtTERT) has now been isolated from cultured cells. The cDNA contains an open reading frame of 3372 bp, encoding a protein with
K Oguchi, Koichiro Tamura
exaly   +2 more sources

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The Structure and Function of Telomerase Reverse Transcriptase

Annual Review of Biochemistry, 2006
The structure and integrity of telomeres are essential for genome stability. Telomere dysregulation can lead to cell death, cell senescence, or abnormal cell proliferation. The maintenance of telomere repeats in most eukaryotic organisms requires telomerase, which consists of a reverse transcriptase (RT) and an RNA template that dictates the synthesis
Chantal, Autexier, Neal F, Lue
openaire   +2 more sources

Telomerase Activity of Reverse Transcriptase

Science, 1997
In their report “Reverse transcriptase motifs in the catalytic subunit of telomerase” ([25 Apr., p. 561][1]), Joachim Lingner et al . demonstrate that such motifs are present in the catalytic subunit of the telomerase that they purified and identified in Euplotes aediculatus .
Ricchetti, Miria, Buc, Henri
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Expression of Human Telomerase Reverse Transcriptase in Lymphangioleiomyomatosis

American Journal of Respiratory and Critical Care Medicine, 2002
Abstract Telomerase synthesizes nucleotide hexameric repeats (telomeres) at the ends of chromosomes, replacing base sequences that are lost from these sites during each mitotic cycle and protecting these ends against the action of exonucleases and ligases. Therefore, telomerase is essential for maintaining cellular replication.
Fumiyuki, Kumaki, Kazuyo, Takeda, Zu-Xi, Yu, Joel, Moss, Victor J, Ferrans   +4 more
openaire   +2 more sources

Activation of telomerase and expression of human telomerase reverse transcriptase in coronary atherosclerosis

Cardiovascular Pathology, 2005
Considerable research on telomerase on human neoplastic and normal long-lived proliferative tissues has emerged. We explored the expression of telomerase in atherosclerotic human epicardial coronary arteries.Forty discrete human coronary arterial segments obtained from 19 heart transplant recipients were classified into nonatherosclerotic and ...
Shih-Chi, Liu, Shoei-Shen, Wang, Mu-Zon, Wu, Deng-Chyang, Wu, Fang-Jung, Yu, Wen-Jone, Chen, Fu-Tien, Chiang, Meng-Fen, Yu   +7 more
openaire   +2 more sources

Telomerase reverse transcriptase mRNA expression and telomerase activity in hepatocellular carcinoma

Journal of Gastroenterology, 1999
Human telomerase reverse transcriptase (hTERT) has been identified as the catalytic subunit of human telomerase. To clarify the clinical significance of hTERT mRNA in hepatocellular carcinoma (HCC), we investigated the relationship between telomerase activity and hTERT mRNA in human HCC and non-HCC tissues. The hTERT mRNA was detected in 17 (89.47%) of
K, Nagao, M, Tomimatsu, H, Endo, H, Hisatomi, K, Hikiji   +4 more
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PAX8 Regulates Telomerase Reverse Transcriptase and Telomerase RNA Component in Glioma

Cancer Research, 2008
Abstract Paired box (PAX) developmental genes are frequently expressed in cancers and confer survival advantages on cancer cells. We have previously found that PAX genes are deregulated in glioma. We have now investigated the expression of PAX genes in glioma and their role in telomere maintenance.
Yu-Jen, Chen, Hamish G, Campbell, Anna K, Wiles, Michael R, Eccles, Roger R, Reddel, Antony W, Braithwaite, Janice A, Royds   +6 more
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TELOMERASE REVERSE TRANSCRIPTASE IN ATHEROSCLEROSIS

2017
Telomerase reverse transcriptase (TERT) is the catalytic subunit of telomerase and the limiting factor for the enzyme activity. The expression of TERT and telomerase activity is increased in atherosclerotic plaques. However, the role of TERT dysregulation during atherosclerosis formation remains unknown.
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The significance of human telomerase reverse transcriptase (hTERT) in cancer

European Journal of Surgical Oncology (EJSO), 2001
Since the discovery of the enzyme telomerase in humans, it has become apparent that it is the most general of tumour markers known, and enormously significant in its potential for diagnostic, prognostic and therapeutic applications. Extensive work has identified three core components of the enzyme, of which the catalytic subunit hTERT (human telomerase
K L, Kirkpatrick, K, Mokbel
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