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Telomerase is a true reverse transcriptase. A review.
Biochemistry. Biokhimiia, 1998Synthesis of telomeric repeats at chromosome ends requires telomerase, a ribonucleoprotein enzyme. The RNA subunit, which contains the template for DNA synthesis, has been identified in many organisms. Recently, the protein subunit that catalyzes telomeric DNA extension has also been identified in Euplotes aediculatus and Saccharomyces cerevisiae.
T R, Cech, T M, Nakamura, J, Lingner
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A second chance for telomerase reverse transcriptase in anticancer immunotherapy
Nature Reviews Clinical Oncology, 2016Telomerase reverse transcriptase (TERT) is a self-antigen that is expressed constitutively in many tumours, and is, therefore, an important target for anticancer immunotherapy. In the past 10 years, trials of immunotherapy with TERT-based vaccines have demonstrated only modest benefits. In this Perspectives, I discuss the possible immunological reasons
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Immunoprecipitation of Human Telomerase Reverse Transcriptase with Telomerase Activity
Analytical Biochemistry, 2001J M, Kraveka +3 more
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Non-canonical functions of Telomerase Reverse Transcriptase – Impact on redox homeostasis
Redox Biology, 2020Philipp Jakobs +2 more
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The telomerase reverse transcriptase regulates chromatin state and DNA damage responses
Proceedings of the National Academy of Sciences of the United States of America, 2005Kenkichi Masutomi +2 more
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