Results 51 to 60 of about 128,505 (270)

Many Disease-Associated Variants of hTERT Retain High Telomerase Enzymatic Activity [PDF]

, 2013
Mutations in the gene for telomerase reverse transcriptase (hTERT) are associated with diseases including dyskeratosis congenita, aplastic anemia, pulmonary fibrosis and cancer.
Campbell, Kristina, Cech, Thomas R, Crary, Sharon M, Fioravanti, Matthew Jesse, Zaug, Arthur J   +4 more
core   +5 more sources

Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Telomerase, which extends DNA at chromosome ends, is composed of an RNA template and a catalytic protein subunit, telomerase reverse transcriptase (TERT).
T. Rowland, Gabrijela Dumbović, Evan P. Hass, J. Rinn, T. Cech   +4 more
semanticscholar   +1 more source

Prognostic Relevance of hTERT mRNA Expression in Ductal Adenocarcinoma of the Pancreas

Neoplasia: An International Journal for Oncology Research, 2008
Telomerase is thought to play an essential role in tumorigenesis and progression. Its activity is directly correlated with the expression of its catalytic subunit, human telomerase reverse transcriptase (hTERT).
Lukasz-Filip Grochola, Thomas Greither, Helge W. Taubert, Peter Möller, Uwe Knippschild, Andrej Udelnow, Doris Henne-Bruns, Peter Würl   +7 more
doaj   +1 more source

The predictive and prognostic potential of plasma telomerase reverse transcriptase (TERT) RNA in rectal cancer patients [PDF]

, 2018
Background: Preoperative chemoradiotherapy (CRT) followed by surgery is the standard care for locally advanced rectal cancer, but tumour response to CRT and disease outcome are variable.
A Celeghin, A Habr-Gama, AL Appelt, Alessandro Perin, AM Mandard, Angela Buonadonna, Anita De Rossi, Antonino De Paoli, C Alix-Panabières, C Belluco, Caterina Boso, Claudio Belluco, D Beddy, D Hanahan, D Lin, D Tural, E Rampazzo, E Rampazzo, E Rampazzo, EH Blackburn, Elisa Palazzari, Enrica Rampazzo, Francesca Bergamo, G Saretzki, G Spolverato, Giovanna Spiro, I Gingras, J Buijsen, J Maláska, JA March-Villalba, JF Bosset, JM Lewis, JP Gerard, K Bujko, K Kojima, L Moureau-Zabotto, L Terrin, L Terrin, LA Torre, M Maas, M Spornraft, MB Amin, MS Roh, N Miura, N Tani, P Boscolo-Rizzo, Paola Del Bianco, R Bertorelle, R Bertorelle, R Sauer, R Siegel, RK Deblakshmi, Roberta Bertorelle, S Giunco, S Pucciarelli, S Pucciarelli, Salvatore Pucciarelli, Sara Leonardi, SB Edge, SH Lim, SM Lledó, T El-Hefnawy, Y Kang   +62 more
core   +1 more source

Transcriptional Regulation of Telomerase Reverse Transcriptase (TERT) by MYC

Front. Cell Dev. Biol., 2017
Telomerase elongates telomeres and is crucial for maintaining genomic stability. While stem cells and cancer cells display high telomerase activity, normal somatic cells lack telomerase activity primarily due to transcriptional repression of telomerase ...
Ekta Khattar, V. Tergaonkar
semanticscholar   +1 more source

An Alternate Splicing Variant of the Human Telomerase Catalytic Subunit Inhibits Telomerase Activity

Neoplasia: An International Journal for Oncology Research, 2000
Telomerase, a cellular reverse transcriptase, adds telomeric repeats to chromosome ends. In normal human somatic cells, telomerase is repressed and telomeres progressively shorten, leading to proliferative senescence.
Xiaoming Yi, Dennis M. White, Dara L. Aisner, Joseph A. Baur, Woodring E. Wright, Jerry W. Shay   +5 more
doaj   +1 more source

A Common Cancer Risk-Associated Allele in the hTERT Locus Encodes a Dominant Negative Inhibitor of Telomerase. [PDF]

PLoS Genetics, 2015
The TERT-CLPTM1L region of chromosome 5p15.33 is a multi-cancer susceptibility locus that encodes the reverse transcriptase subunit, hTERT, of the telomerase enzyme. Numerous cancer-associated single-nucleotide polymorphisms (SNPs), including rs10069690,
Anagha Killedar, Michael D Stutz, Alexander P Sobinoff, Christopher G Tomlinson, Tracy M Bryan, Jonathan Beesley, Georgia Chenevix-Trench, Roger R Reddel, Hilda A Pickett   +8 more
doaj   +1 more source

Telomeres in Evolution and Development from Biosemiotic Perspective [PDF]

, 2007
Telomeres identify natural chromosome ends being different from broken DNA through differences in their "molecular syntax" (M.Eigen) which determines the functions of reverse transcriptase and its integrated RNA template, telomerase.
Guenther Witzany
core   +3 more sources

Role of telomerase expression in interstitial lung diseases

The Egyptian Journal of Bronchology, 2019
Background Telomeres are hexameric nucleotide sequences. The biological role of telomeres is to prevent shortening of DNA to preserve integrity of the genome. Length of telomeres is determined by age, sex, and environmental exposures.
Marwa M. Shaban, Radwa A. Elhefny, Sabah H. Hussein, Amul A. Badr, Zeinab A. Nour   +4 more
doaj   +1 more source

hTERT protein expression is independent of clinicopathological parameters and c-Myc protein expression in human breast cancer [PDF]

Background Telomerase is a ribonucleoprotein enzyme that synthesises telomeres after cell division and maintains chromosomal stability leading to cellular immortalization.
Blake, JRS, Elkak, AE, Meligonis, G, Mitchell, B, Mokbel, K, Newbold, RF, Salhab, M   +6 more
core   +3 more sources