Results 61 to 70 of about 128,505 (270)

Telomerase reverse transcriptase promoter mutations in bladder cancer: High frequency across stages, detection in urine, and lack of association with outcome [PDF]

, 2014
Background Hotspot mutations in the promoter of the gene coding for telomerase reverse transcriptase (TERT) have been described and proposed to activate gene expression.
Abas, C.S. (Cheno), Allory, Y. (Yves), Beukers, W. (Willemien), Carrato, A. (Alfredo), Carrillo-de Santa Pau, E. (Enrique), Dyrskjot, L. (Lars), Flández, M. (Marta), Keur, K.A. (Kirstin) van der, Kogevinas, M. (Manolis), Lloreta, J. (Josep), Lorente, J.A. (José), Lurkin, I. (Irene), Malats, N. (Núria), Marqués, M. (Miriam), Masius, R.G. (Roy), Márquez, M. (Mirari), Orntoft, T.F. (Torben), Real, F.X. (Francisco), Sagrera, A. (Ana), Steyerberg, E.W. (Ewout), Tilborg, A.A.G. (Angela) van, Vermeij, M. (Marcel), Zuiverloon, T.C.M. (Tahlita), Zwarthoff, E.C. (Ellen)   +23 more
core   +4 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Telomeres and Cancer

Life, 2021
Telomeres cap the ends of eukaryotic chromosomes and are indispensable chromatin structures for genome protection and replication. Telomere length maintenance has been attributed to several functional modulators, including telomerase, the shelterin ...
Hueng-Chuen Fan, Fung-Wei Chang, Jeng-Dau Tsai, Kao-Min Lin, Chuan-Mu Chen, Shinn-Zong Lin, Ching-Ann Liu, Horng-Jyh Harn   +7 more
doaj   +1 more source

Development and characterization of a new human hepatic cell line [PDF]

, 2015
The increasing demand and hampered use of primary human hepatocytes for research purposes have urged scientists to search for alternative cell sources, such as immortalized hepatic cell lines.
Berx, Geert, De Craene, Bram, De Kock, Joey, Ramboer, Eva, Rogiers, Vera, Vanhaecke, Tamara, Vinken, Mathieu   +6 more
core   +3 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Telomerase promoter mutations in human immunodeficiency virus-related conjunctiva neoplasia

Journal of Translational Medicine, 2018
Background Squamous cell carcinoma (SCC) of the conjunctiva is a common cancer in Africa mainly associated with solar ultraviolet (UV) exposure and human immunodeficiency virus (HIV) infection.
Noemy Starita, Luigi Buonaguro, Franco M. Buonaguro, Maria Lina Tornesello   +3 more
doaj   +1 more source

Tianshengyuan-1 (TSY-1) regulates cellular Telomerase activity by methylation of TERT promoter. [PDF]

, 2016
Telomere and Telomerase have recently been explored as anti-aging and anti-cancer drug targets with only limited success. Previously we showed that the Chinese herbal medicine Tianshengyuan-1 (TSY-1), an agent used to treat bone marrow deficiency, has a ...
Chow, Michelle, Jin, Yusheng, Li, Yawei, Qin, Xiaotian, Rao, Jianyu, Santiskulvong, Chintda, Vu, Victor, Yu, Weibo, Zeng, Gang, Zhang, Zuofeng   +9 more
core   +2 more sources

Luteolin inhibits cell cycle progression and induces apoptosis of breast cancer cells through downregulation of human telomerase reverse transcriptase

Oncology Letters, 2019
Luteolin is a flavonoid, which has been extensively investigated due to its antitumor effects; however, the underlying mechanisms of its action remain largely unknown. The present study aimed to investigate the role of luteolin in breast cancer (BC), and
Liming Huang, K. Jin, H. Lan
semanticscholar   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

The Mechanisms of Telomere and Telomerase Regulation in Hematologic Malignancies [PDF]

, 2014
11518
AKIYAMA,　Masaharu, KAWAUCHI,　Kiyotaka, YAMADA,　Osamu   +2 more
core   +4 more sources