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A high-throughput method for quantifying relative telomere length in single cells in situ combined with live-cell imaging. [PDF]
J Mol Cell BiolSun Q, Zou Z, Min M.
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The leaves fall, yet the tree endures. [PDF]
Cell Mol Life SciFojtová M, Schrumpfová PP, Fajkus J.
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Telomeres, Telomerase, and Curcumin: A New Frontier in Cancer Therapy: A Narrative Review. [PDF]
BiomedicinesAlbadrani HM, Zakariyah AF.
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Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
Nature Reviews Cancer, 2011Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are progressively lost with each round of cell division. Telomere protection requires a minimal length of TTAGGG repeats to allow the binding of shelterin, which prevents the activation of a DNA damage response (DDR) at chromosome ends.
Paula Mart�nez, Mar�a A. Blasco
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Journal of Pediatric Surgery, 2009
Neuroblastoma (NBL) shows remarkable biologic heterogeneity, resulting in favorable or unfavorable prognoses. Previously, we reported that most unfavorable NBLs express high telomerase activity to maintain telomere length. Recently, telomere binding proteins (TBPs) and alternative lengthening of telomeres (ALTs) have been identified as key factors of ...
Yoshiyuki, Onitake +5 more
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Neuroblastoma (NBL) shows remarkable biologic heterogeneity, resulting in favorable or unfavorable prognoses. Previously, we reported that most unfavorable NBLs express high telomerase activity to maintain telomere length. Recently, telomere binding proteins (TBPs) and alternative lengthening of telomeres (ALTs) have been identified as key factors of ...
Yoshiyuki, Onitake +5 more
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Dynamic DNA Shortening by Telomere-Binding Protein Cdc13
Journal of the American Chemical Society, 2021Telomeres are essential for chromosome maintenance. Cdc13 is a single-stranded telomeric DNA binding protein that caps telomeres and regulates telomerase function in yeast. Although specific binding of Cdc13 to telomeric DNA is critical for telomere protection, the detail mechanism how Cdc13-DNA complex protects telomere is unclear.
Yi-Yun Lin +6 more
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Inaccessibility of theEuplotes telomere binding protein
Chromosoma, 1993The telomere binding protein (TP) from the macronucleus of the ciliate Euplotes eurystomus was purified by removal of tenaciously bound DNA with hydroxylapatite, and the purified TP partially sequenced. Rabbit antiserum was generated against a synthetic peptide of 14 amino acids at the amino-terminus of the TP.
A L, Olins +4 more
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