Results 191 to 200 of about 116,824 (219)
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Nature Medicine, 1996
The enzyme, telomerase, may be switched on in tumor cells. Inhibitors of this enzyme might constitute a new class of anti-cancer drugs.
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The enzyme, telomerase, may be switched on in tumor cells. Inhibitors of this enzyme might constitute a new class of anti-cancer drugs.
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Physiological Reviews, 2008
Telomeres play a central role in cell fate and aging by adjusting the cellular response to stress and growth stimulation on the basis of previous cell divisions and DNA damage. At least a few hundred nucleotides of telomere repeats must “cap” each chromosome end to avoid activation of DNA repair pathways.
Geraldine, Aubert, Peter M, Lansdorp
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Telomeres play a central role in cell fate and aging by adjusting the cellular response to stress and growth stimulation on the basis of previous cell divisions and DNA damage. At least a few hundred nucleotides of telomere repeats must “cap” each chromosome end to avoid activation of DNA repair pathways.
Geraldine, Aubert, Peter M, Lansdorp
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Scientific American, 1991
An ultimate goal of human genetics is the generation of a complete physical and ''functional'' map of the human genome. Twenty-five percent of human DNA, however, consists of repetitive DNA sequences. These repetitive DNA sequences are thought to arise by many mechanisms, from direct sequence amplification by the unequal recombination of homologous DNA
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An ultimate goal of human genetics is the generation of a complete physical and ''functional'' map of the human genome. Twenty-five percent of human DNA, however, consists of repetitive DNA sequences. These repetitive DNA sequences are thought to arise by many mechanisms, from direct sequence amplification by the unequal recombination of homologous DNA
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Experimental Gerontology, 2007
The extent and potential significance of telomere erosion, as a function of age in human tissues, is becoming increasingly apparent. In this, the second yearly review on telomeres and ageing, I review a small selection of papers published between July 2006 and June 2007.
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The extent and potential significance of telomere erosion, as a function of age in human tissues, is becoming increasingly apparent. In this, the second yearly review on telomeres and ageing, I review a small selection of papers published between July 2006 and June 2007.
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Current Opinion in Genetics & Development, 1993
The ends of eukaryotic chromosomes are defined by specialized nucleoprotein complexes called telomeres. Telomeres impart stability to the genome and are of general interest due to their unique structure and unconventional mode of synthesis. Recent work has identified new components of the telomere complex and expanded our understanding of the role of ...
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The ends of eukaryotic chromosomes are defined by specialized nucleoprotein complexes called telomeres. Telomeres impart stability to the genome and are of general interest due to their unique structure and unconventional mode of synthesis. Recent work has identified new components of the telomere complex and expanded our understanding of the role of ...
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Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity
Cancer Cell, 2020Ilgen Mender, Anli Zhang, Zhenhua Ren
exaly
The Role of Telomere Biology in Cancer
Annual Review of Pathology: Mechanisms of Disease, 2013Lifeng Xu, Shang Li, Bradley A Stöhr
exaly