Results 171 to 180 of about 130,635 (210)

Telomere uncapping and alternative lengthening of telomeres

Mechanisms of Ageing and Development, 2008
A substantial number of human tumors utilize a telomerase-independent telomere length maintenance mechanism referred to as alternative lengthening of telomeres (ALT). Although it is known that ALT is a telomere-specific, loss of function phenotype, which involves lengthening of telomeres by homologous recombination-mediated replication of telomeric DNA,
Anthony J, Cesare, Roger R, Reddel
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The telomere syndromes [PDF]

Nature Reviews Genetics, 2012
There has been mounting evidence of a causal role for telomere dysfunction in a number of degenerative disorders. Their manifestations encompass common disease states such as idiopathic pulmonary fibrosis and bone marrow failure. Although these disorders seem to be clinically diverse, collectively they comprise a single syndrome spectrum defined by the
Elizabeth Blackburn, Mary Armanios
exaly   +5 more sources

Telomeres

Trends in Biochemical Sciences, 1986
Telomeres are specialized structures at the ends of eukaryotic linear chromosomes, consisting of protein-bound tandemly repeated simple DNA sequences. Telomeric DNA is unique in that it is copied from an RNA template that forms part of the enzyme, telomerase. This review discusses the synthesis and maintenance of these unusual structures.
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Cats – telomere to telomere and nose to tail

Trends in Genetics, 2021
Feline genomic medicine can decode human variants of uncertain significance (VUSs). Telomere-to-telomere genome assemblies are feasible for all felid species, supporting genetic evolution and speciation studies. Their highly conserved genomic organization compared to humans suggests cats may also decipher the intergenic variation affecting the 3D ...
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Centromeres and telomeres

Current Opinion in Cell Biology, 1992
Centromeres and telomeres are both composed of specific DNA sequences and unique chromosomal proteins. Isolation and characterization of some of these sequences and proteins has greatly increased our knowledge of centromere and telomere structure. This information is allowing us to determine how centromeres and telomeres perform their various roles in ...
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Telomere biology in neuroblastoma: telomere binding proteins and alternative strengthening of telomeres

Journal of Pediatric Surgery, 2009
Neuroblastoma (NBL) shows remarkable biologic heterogeneity, resulting in favorable or unfavorable prognoses. Previously, we reported that most unfavorable NBLs express high telomerase activity to maintain telomere length. Recently, telomere binding proteins (TBPs) and alternative lengthening of telomeres (ALTs) have been identified as key factors of ...
Yoshiyuki, Onitake, Eiso, Hiyama, Naomi, Kamei, Hiroaki, Yamaoka, Taijiro, Sueda, Keiko, Hiyama   +5 more
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TELOMERES AND THEIR CONTROL

Annual Review of Genetics, 2000
▪ Abstract  Telomeres are DNA and protein structures that form complexes protecting the ends of chromosomes. Understanding of the mechanisms maintaining telomeres and insights into their function have advanced considerably in recent years. This review summarizes the currently known components of the telomere/telomerase functional complex, and focuses ...
M J, McEachern, A, Krauskopf, E H, Blackburn   +2 more
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Telomeres to go

Science Signaling, 2022
By acquiring telomeres from antigen-presenting cells, some T cells are protected from senescence.
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The Ruminant Telomere-to-Telomere (RT2T) Consortium

Nature Genetics
Telomere-to-telomere (T2T) assemblies reveal new insights into the structure and function of the previously 'invisible' parts of the genome and allow comparative analyses of complete genomes across entire clades. We present here an open collaborative effort, termed the 'Ruminant T2T Consortium' (RT2T), that aims to generate complete diploid assemblies ...
Kalbfleisch, Theodore, Mckay, Stephanie, Murdoch, Brenda, Adelson, David, Almansa-Villa, Diego, Becker, Gabrielle, Beckett, Linda, Benítez-Galeano, María José, Biase, Fernando, Casey, Theresa, Chuong, Edward, Clark, Emily, Clarke, Shannon, Cockett, Noelle, Couldrey, Christine, Davis, Brian, Elsik, Christine, Faraut, Thomas, Gao, Yahui, Genet, Carine, Grady, Patrick, Green, Jonathan, Green, Richard, Guan, Dailu, Hagen, Darren, Hartley, Gabrielle, Heaton, Mike, Hoyt, Savannah, Huang, Wen, Jarvis, Erich, Kalleberg, Jenna, Khatib, Hasan, Koepfi, Klaus-Peter, Koltes, James, Koren, Sergey, Kuehn, Christa, Leeb, Tosso, Leonard, Alexander, Liu, George, Low, Wai Yee, Mcconnell, Hunter, Mcrae, Kathryn, Miga, Karen, Mousel, Michelle, Neibergs, Holly, Olagunju, Temitayo, Pennell, Matt, Petry, Bruna, Pewsner, Mirjam, Phillippy, Adam, Pickett, Brandon, Pineda, Paulene, Potapova, Tamara, Rachagani, Satyanarayana, Rhie, Arang, Rijnkels, Monique, Robic, Annie, Rodriguez Osorio, Nelida, Safonova, Yana, Schettini, Gustavo, Schnabel, Robert, Sirpu Natesh, Nagabhishek, Stegemiller, Morgan, Storer, Jessica, Stothard, Paul, Stull, Caleb, Tosser-Klopp, Gwenola, Traglia, Germán, Tuggle, Christopher, van Tassell, Curtis, Watson, Corey, Weikard, Rosemarie, Wimmers, Klaus, Xie, Shangqian, Yang, Liu, Smith, Timothy, O’neill, Rachel, Rosen, Benjamin   +77 more
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The Human Telomere

Scientific American, 1991
An ultimate goal of human genetics is the generation of a complete physical and ''functional'' map of the human genome. Twenty-five percent of human DNA, however, consists of repetitive DNA sequences. These repetitive DNA sequences are thought to arise by many mechanisms, from direct sequence amplification by the unequal recombination of homologous DNA
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