Results 181 to 190 of about 130,635 (210)
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2008
The ends of chromosomes consist of a hexanucleotide DNA repeat sequence and specialized DNA-binding and telomere-associated proteins. An enzyme activity called telomerase maintains telomere length by using an RNA template (TR) and a reverse transcriptase (TERT) to add the hexanucleotide sequence to the free chromosome end. The structure of telomeres is
Mark P, Mattson +2 more
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The ends of chromosomes consist of a hexanucleotide DNA repeat sequence and specialized DNA-binding and telomere-associated proteins. An enzyme activity called telomerase maintains telomere length by using an RNA template (TR) and a reverse transcriptase (TERT) to add the hexanucleotide sequence to the free chromosome end. The structure of telomeres is
Mark P, Mattson +2 more
openaire +2 more sources
Human Telomeres and Telomere Biology Disorders
2014Telomeres consist of long nucleotide repeats and a protein complex at chromosome ends essential for chromosome stability. Telomeres shorten with each cell division and thus are markers of cellular age. Dyskeratosis congenita (DC) is a cancer-prone inherited bone marrow failure syndrome caused by germ-line mutations in key telomere biology genes that ...
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Mechanisms of Ageing and Development, 2008
Associations between telomere length and various chronic diseases associated with ageing have led to the suggestion that telomere length may be an ageing biomarker. At the clinical level, the suggestion of using measurements of frailty as a measure of biological ageing has also been suggested. This study examines the hypothesis that telomere shortening
J, Woo +4 more
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Associations between telomere length and various chronic diseases associated with ageing have led to the suggestion that telomere length may be an ageing biomarker. At the clinical level, the suggestion of using measurements of frailty as a measure of biological ageing has also been suggested. This study examines the hypothesis that telomere shortening
J, Woo +4 more
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Current Opinion in Genetics & Development, 1993
The ends of eukaryotic chromosomes are defined by specialized nucleoprotein complexes called telomeres. Telomeres impart stability to the genome and are of general interest due to their unique structure and unconventional mode of synthesis. Recent work has identified new components of the telomere complex and expanded our understanding of the role of ...
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The ends of eukaryotic chromosomes are defined by specialized nucleoprotein complexes called telomeres. Telomeres impart stability to the genome and are of general interest due to their unique structure and unconventional mode of synthesis. Recent work has identified new components of the telomere complex and expanded our understanding of the role of ...
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Science, 1990
Telomeres, the specialized DNA-protein structures found at the ends of every eukaryotic chromosome, are required to stabilize chromosomes. Telomeric DNA, comprising the extreme molecular ends of chromosomes, consists of simple tandemly repeated sequences, characterized by clusters of G residues is one strand.
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Telomeres, the specialized DNA-protein structures found at the ends of every eukaryotic chromosome, are required to stabilize chromosomes. Telomeric DNA, comprising the extreme molecular ends of chromosomes, consists of simple tandemly repeated sequences, characterized by clusters of G residues is one strand.
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Cold Spring Harbor Perspectives in Biology
Telomeres represent a molecular nexus where genome stability, aging, disease susceptibility, and regenerative potential converge. Advances in understanding how telomeres are replicated, protected, and repaired now inform fundamental questions about human lifespan, tissue renewal, the molecular origins of age-related decline, and cancer evolution.
Cooper, Julia Promisel +3 more
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Telomeres represent a molecular nexus where genome stability, aging, disease susceptibility, and regenerative potential converge. Advances in understanding how telomeres are replicated, protected, and repaired now inform fundamental questions about human lifespan, tissue renewal, the molecular origins of age-related decline, and cancer evolution.
Cooper, Julia Promisel +3 more
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Nature Medicine, 1996
The enzyme, telomerase, may be switched on in tumor cells. Inhibitors of this enzyme might constitute a new class of anti-cancer drugs.
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The enzyme, telomerase, may be switched on in tumor cells. Inhibitors of this enzyme might constitute a new class of anti-cancer drugs.
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Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization
Nature Reviews Molecular Cell Biology, 2021Thomas Cech, Ci Ji Lim
exaly
From shortening telomeres to replicative crisis
Nature Reviews Molecular Cell Biology, 2023Paulina Strzyz
exaly