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Telomere length in reproduction
Andrologia, 2012Telomeres, noncoding hexameric tandem repeats located at the ends of chromosomes, maintain chromosome stability and genome integrity. These guanine-rich repeats are highly conserved during evolution, and their role is dependent on their length and structure.
J, Thilagavathi, S, Venkatesh, R, Dada
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2007
Most somatic cells of long-lived species undergo telomere shortening throughout life. Critically short telomeres trigger loss of cell viability in tissues, which has been related to alteration of tissue function and loss of regenerative capabilities in aging and aging-related diseases.
Andrés, Canela +2 more
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Most somatic cells of long-lived species undergo telomere shortening throughout life. Critically short telomeres trigger loss of cell viability in tissues, which has been related to alteration of tissue function and loss of regenerative capabilities in aging and aging-related diseases.
Andrés, Canela +2 more
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Interchromosomal Telomere Length Variation
Biochemical and Biophysical Research Communications, 2002Despite the recent discovery of interchromosomal telomere length variation, a role for heterogeneity in telomere maintenance has yet to be established. This study aimed to clarify relative telomere length differences between chromosomes. Combined chromosomal sorting and telomeric repeat content analysis in GM130B cells, the relative telomeric repeat ...
Takeshi, Suda +8 more
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Annual Review of Biochemistry, 1996
Telomeres are the components of chromosome ends that provide stability and allow the complete replication of the ends. Telomere length is maintained by a balance between processes that lengthen and those that shorten telomeres. Telomeraseis a ribonucleoprotein polymerase that specifically elongates telomeres.
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Telomeres are the components of chromosome ends that provide stability and allow the complete replication of the ends. Telomere length is maintained by a balance between processes that lengthen and those that shorten telomeres. Telomeraseis a ribonucleoprotein polymerase that specifically elongates telomeres.
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Telomere length and vitamin B12
2022Telomeres are non-coding nucleoprotein structures consisting of a highly conserved tandem repeat DNA sequence that caps the ends of chromosomes in eukaryotes. Telomeres confer chromosomal stability, protect the genome from nucleolytic degradation, avoid aberrant recombination and improper repair, and prevent random fusion of chromosomes.
Guruvaiah, Praveen +2 more
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Telomere Amount and Length Assay
Pharmaceutical Research, 2001Telomeres are specific DNA structure at the ends of chromosomes to protect chromosomes from fusion, recombination, and degradation. Telomere length changes are implicated in cell senescence, aging, tumorigenesis, and DNA repair. The standard method for measuring telomere length is Southern blot analysis.
Y, Gan +3 more
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Telomere length predicts cardiovascular disease
BMJ, 2014Measurement in humans is unlikely to be useful until we find out how and why Atherosclerosis is an age related disease characterised by systemic oxidative stress and low grade chronic inflammation. Telomeres consist of DNA repeats at the ends of chromosomes, which shorten with every cell division.
Ioakim, Spyridopoulos +1 more
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Recombination in telomere-length maintenance
Trends in Biochemical Sciences, 2000Although telomerase is the major mechanism for telomere elongation in most cells, telomerase-independent mechanisms of telomere maintenance can allow cell survival. Yeast cells that lack telomerase maintain telomere length through a form of recombination known as gene conversion.
A, Kass-Eisler, C W, Greider
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Telomere length inheritance and aging
Mechanisms of Ageing and Development, 2008Telomere shortening accompanies human aging, and premature aging syndromes are often associated with short telomeres. These two observations are central to the hypothesis that telomere length directly influences longevity. If true, genetically determined mechanisms of telomere length homeostasis should significantly contribute to variations of ...
Dennis, Kappei +1 more
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Telomere length and telomere-centromere relationships?
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1998The quantitative fluorescence in situ hybridization (Q-FISH) technique enables an accurate estimate of individual telomere lengths, a possibility beyond the resolution of conventional techniques. So far, Q-FISH has been used for the estimate of individual telomere lengths in human, mouse and Chinese hamster chromosomes.
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