Results 61 to 70 of about 57,502 (259)

Telomere length in offspring is determined by mitochondrial-nuclear communication at fertilization

Nature Communications
The initial setting of telomere length during early life in each individual has a major influence on lifetime risk of aging-associated diseases; however there is limited knowledge of biological signals that regulate inheritance of telomere length, and ...
Yasmyn E. Winstanley, Ryan D. Rose, Alexander P. Sobinoff, Linda L. Wu, Deepak Adhikari, Qing-Hua Zhang, Jadon K. Wells, Lee H. Wong, Hazel H. Szeto, Sandra G. Piltz, Paul Q. Thomas, Mark A. Febbraio, John Carroll, Hilda A. Pickett, Darryl L. Russell, Rebecca L. Robker   +15 more
doaj   +1 more source

Mammalian chromosome–telomere length dynamics [PDF]

Royal Society Open Science, 2018
Individual chromosome arms have specific individual telomere lengths (TLs). Past studies within species have shown strong positive correlations between individual chromosome length and TL at that chromosome. While the reasons for these associations are unclear, the strength and consistency of the associations across disparate taxa suggest that this is ...
Amy R. Klegarth, Dan T. A. Eisenberg
openaire   +3 more sources

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

Advanced Science, EarlyView.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu, Qiongcong Xu, Jinzhao Xie, Mingjian Ma, Xitai Huang, Yinhao Shi, Jiawei Zhou, Enliang Zhu, Ziyi Zhao, Ning Zhang, Zhide Liu, Jingyuan Ye, Xiaoyu Yin   +12 more
wiley   +1 more source

Time‐Efficient and Informatic‐Skill‐Light Gap‐Filling for Telomere‐to‐Telomere Genome Assembly

Advanced Science, EarlyView.
The paper introduces a novel auxiliary software toolbox GapSuite, consisting of two tools Gap‐Aid and Gap‐Graph, which guides users to fill gaps in chromosome‐level genome assembly using sequence‐extension‐based and assembly‐graph‐based strategies. The two tools enable users with limited informatics expertise to efficiently complete gap‐filling on ...
Dong Xu, Xianjia Zhao, Lianguang Shang, Shaolong Tian, Yanchun Li, Huaming Wen, Qiang Xu, Dongxi Li, Weihua Pan   +8 more
wiley   +1 more source

Telomere Length in the Newborn [PDF]

Pediatric Research, 2002
Telomere length is similar in different organs of the human fetus but variable among fetuses. During extrauterine life telomere length is highly variable among individuals and longer in women than men. In the present work we addressed the following questions: 1) Are there sex-related differences in telomere length at birth?
Koji, Okuda, Arlene, Bardeguez, Jeffrey P, Gardner, Paulette, Rodriguez, Vijaya, Ganesh, Masayuki, Kimura, Joan, Skurnick, Girgis, Awad, Abraham, Aviv   +8 more
openaire   +2 more sources

Intelligent Thermo‐Self‐Limited Magnetothermia with Heat‐Triggered TERT Silencing for Precision Synergetic Cancer Therapy

Advanced Science, EarlyView.
Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang, Mingfu Gong, Tao Sun, Shilin Xiao, Yue Zhao, Xiaofeng Yang, Wansu Zhang, Chunyu Zhou, Xu Liu, Dong Zhang   +9 more
wiley   +1 more source

Telomere G-tail Length is a Promising Biomarker Related to White Matter Lesions and Endothelial Dysfunction in Patients With Cardiovascular Risk: A Cross-sectional Study

EBioMedicine, 2015
Background: The telomeric 3′-overhang (G-tail) length is essential for the biological effects of telomere dysfunction in vitro, but the association of length with aging and cardiovascular risk is unclear in humans. We investigated the association between
Tomohisa Nezu, Naohisa Hosomi, Tetsuya Takahashi, Kumiko Anno, Shiro Aoki, Akira Shimamoto, Hirofumi Maruyama, Tomonori Hayashi, Masayasu Matsumoto, Hidetoshi Tahara   +9 more
doaj   +1 more source

Short telomeres initiate telomere recombination in primary and tumor cells. [PDF]

PLoS Genetics, 2009
Human tumors that lack telomerase maintain telomeres by alternative lengthening mechanisms. Tumors can also form in telomerase-deficient mice; however, the genetic mechanism responsible for tumor growth without telomerase is unknown.
Tammy A Morrish, Carol W Greider
doaj   +1 more source

Telomere length and cardiovascular disease

Archives of Cardiovascular Diseases, 2010
Telomeres are structures composed of deoxyribonucleic acid repeats that protect the end of chromosomes, but shorten with each cell division. They have been the subject of many studies, particularly in the field of oncology, and more recently their role in the onset, development and prognosis of cardiovascular disease has generated considerable interest.
Saliques, Sébastien, Zeller, Marianne, Lorin, Julie, Lorgis, Luc, Teyssier, Jean-Raymond, Cottin, Yves, Rochette, Luc, Vergely, Catherine   +7 more
openaire   +2 more sources

Telomere length in myelodysplastic syndromes [PDF]

Leukemia & Lymphoma, 2011
The relationship between telomere length (TL) and predisposition to myelodysplastic syndromes (MDS) remains unclear. We compared peripheral blood leukocyte (PBL) TL among cases of histologically confirmed MDS (n = 65) who were treatment-naive with no prior cancer history to age-matched controls (n = 63).
Dana E, Rollison, P K, Epling-Burnette, Jong Y, Park, Ji-Hyun, Lee, Hyun, Park, Kristen, Jonathan, Ashley L, Cole, Jeffrey S, Painter, Mayenha, Guerrier, Johana, Meléndez-Santiago, William, Fulp, Rami, Komrokji, Jeffrey, Lancet, Alan F, List   +13 more
openaire   +2 more sources