Results 181 to 190 of about 66,266 (300)

Fission yeast RPA-TERT-Tpz1TPP1 complex promotes telomere extension and suppresses telomere recombination. [PDF]

PLoS Genet
Moser BA, Points M, Agrawal S, Didier AC, Mennie AK, Lim CJ, Xu YJ, Nakamura TM.   +7 more
europepmc   +1 more source

TERT Promoter Mutations Are Preferentially Associated With the ERBB2 G776‐Altered Subtype of HER2‐Mutant NSCLC

Cancer Science, EarlyView.
A two‐stage clinicogenomic analysis identified and independently validated a preferential association between TERT promoter mutations and the ERBB2 G776‐altered subtype of HER2‐mutant NSCLC, highlighting subtype‐specific genomic heterogeneity. ABSTRACT HER2‐mutant non‐small cell lung cancer (NSCLC) comprises molecularly heterogeneous tumors with ...
Akihiro Yoshimura, Juichiro Yoshida, Chieko Takumi, Koichi Takayama   +3 more
wiley   +1 more source

A Military Veteran with Pulmonary Fibrosis, Hepatic Cirrhosis, Bone Marrow Dysfunction and Shortened Telomeres Found to Have GAVE, a Potential Unsuspected Consequence of Telomere Spectrum Disorder. [PDF]

J Clin Med
Uhlen A, Oudit OA, Patel D, Shah N, Delorenzo L, Vuchula S.   +5 more
europepmc   +1 more source

POLA2‐Related Coats Plus Syndrome: Case Presentation and Description of an Emerging Disorder

Clinical Genetics, EarlyView.
We report an adult male with bilateral retinal vascular disease, hypocellular bone marrow failure, severe gastrointestinal bleeding, and premature hair graying, with telomere lengths near the 10th percentile. Exome sequencing resulted in the diagnosis of POLA2‐related Coats plus syndrome, making him the sixth reported case.
Daniel W. Serber, Ankita Jhuraney, Claire L. Wittowski, Angel Li, Mercy Laurino, Marshall S. Horwitz, Siobán B. Keel, Runjun D. Kumar   +7 more
wiley   +1 more source

Author Correction: Renal fibroblasts are involved in fibrogenic changes in kidney fibrosis associated with dysfunctional telomeres

Experimental and Molecular Medicine
Sarita Saraswati, Paula Martínez, Rosa Serrano, Diego Mejías, Osvaldo Graña-Castro, Ruth Álvarez Díaz, Maria A. Blasco   +6 more
doaj   +1 more source

Brief encounters and lasting impressions—How target protein half‐life affects reactive metabolite signaling

The FEBS Journal, EarlyView.
Lipid‐derived reactive electrophile molecules (REMs) are generated from fatty acids through lipoxygenase or cyclooxygenase‐assisted catalysis, or free radical‐induced lipid peroxidation events. REMs so‐produced covalently modify nearby protein‐cysteines, and in the case of ‘first responder’ proteins, can trigger gain‐of‐function signaling with context ...
Marcus J. C. Long, Lorna Birkby, Yimon Aye   +2 more
wiley   +1 more source

A CRISPR/Cas9-induced blunt-end telomere system in S. pombe reveals RNase H2-dependent RNA primer removal at the terminal Okazaki fragment of lagging telomeres. [PDF]

Nucleic Acids Res
Zou S, Ye T, Fu L, Zhou JQ.
europepmc   +1 more source

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

MUTYH Activity Maintains Telomere Stability in Response to Chronic Telomeric 8-Oxoguanine Damage in Cancer Cells. [PDF]

Biomolecules
De Rosa M, Heidenreich TM, Childs L, Azeroglu B, Toprani SM, Aryamanesh N, Galaviz P, Pickett HA, Lazzerini Denchi E, Nagel ZD, Opresko PL.   +10 more
europepmc   +1 more source

First cytogenetic characterization of the southern pygmy perch Nannoperca australis (Teleostei: Percichthyidae): Karyotype, heterochromatin and repetitive DNA organization

Journal of Fish Biology, EarlyView.
Abstract Chromosome organization and repetitive DNA distribution are important components of genome evolution in teleost fishes but remain poorly characterized in many species of ecological and conservation relevance. We performed a detailed cytogenetic analysis of the southern pygmy perch, Nannoperca australis, a small freshwater species widely used ...
Zuzana Majtánová, Karl G. Moy, Peter J. Unmack, Tariq Ezaz   +3 more
wiley   +1 more source