Results 111 to 120 of about 57,759 (194)

A phase 1b/2 study of cabozantinib in combination with pembrolizumab in advanced cutaneous melanoma

open access: yesCancer, Volume 132, Issue 4, 15 February 2026.
Abstract Background Pembrolizumab is approved for advanced cutaneous melanoma (aCM). Cabozantinib, an oral multi‐tyrosine kinase inhibitor, has demonstrated antitumor activity as monotherapy or in combination with anti‐PD‐1 therapy in malignancies. The objective of this study was to determine the safety and efficacy of cabozantinib and pembrolizumab ...
Yousef Zakharia   +10 more
wiley   +1 more source

Positively Charged Polymers Based on Cyclodextrins for Trametinib and Selumetinib Delivery in Glioblastoma Cancer

open access: yesChemMedChem, Volume 21, Issue 3, 12 February 2026.
β‐cyclodextrin‐based multicharged polymers—linear or cross‐linked—enhance the delivery of mitogen‐activated protein kinase inhibitors (selumetinib, trametinib) in glioblastoma cells. These carriers enhance the antiproliferative effect of the drugs and strengthen extracellular signal‐regulated kinase pathway inhibition.
Noemi Bognanni   +6 more
wiley   +1 more source

MGMT upregulation mediates Temozolomide resistance conferred USP5 dependency. [PDF]

open access: yesSci Rep
Bhardwaj S   +5 more
europepmc   +1 more source

Impact of neuroendocrine neoplasm-specific systemic treatments on expression and function of CXCR4 in neuroendocrine tumor cells. [PDF]

open access: yesSci Rep
Däubler C   +9 more
europepmc   +1 more source

Primary Tumor Size and Tumor-Vessel Interface Following Capecitabine and Temozolomide for Pancreatic Neuroendocrine Tumor. [PDF]

open access: yesCurr Oncol
Guo J   +15 more
europepmc   +1 more source

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